p53 mediated regulation of LINE1 retrotransposition derived R-loops

Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons, comprising around 17% of the human genome, typically remain quiescent in healthy somatic cells but become activated in various cancer types. Our recent investigation reveals that p53 silences L1 transposons in human somatic cells, pote...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Paul, Pratyashaa, Kumar, Arun, De, Astik Kumar, Parida, Ankita Subhadarsani, Bhadke, Gauri, Khatua, Satyajeet, Pattanayak, Fizalin, Tiwari, Bhavana
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Laboratory 20.08.2024
Edition:	1.3
Subjects:	Cancer Biology Cis R-loop Trans R-loop Keywords Transposons RNA-DNA hybrids HDAC inhibitors R-loops L1/LINE1 p53
ISSN:	2692-8205
Online Access:	Get full text
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