Time-resolved structure-function coupling in brain networks

The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we show that structure-function coupling is dynamic and regionally heterogeneou...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Liu, Zhen-Qi, Vázquez-Rodríguez, Bertha, Spreng, R. Nathan, Bernhardt, Boris C., Betzel, Richard F., Misic, Bratislav
Format: Paper
Sprache:Englisch
Veröffentlicht: Cold Spring Harbor Laboratory 09.07.2021
Ausgabe:1.1
Schlagworte:
Neuroscience
ISSN:2692-8205
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Zusammenfassung:The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we show that structure-function coupling is dynamic and regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are highly organized across the cortex. These patterns reflect cortical hierarchies, with stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of structure-function coupling is shaped by the distribution of connection lengths. The time-varying coupling of structural and functional connectivity points towards an informative feature of the brain that may reflect how cognitive functions are flexibly deployed and implemented.
Bibliographie:Competing Interest Statement: The authors have declared no competing interest.
ISSN:2692-8205
DOI:10.1101/2021.07.08.451672