MDC1 counteracts restrained replication fork restart and its loss causes chemoresistance in BRCA1/2-deficient mammary tumors

MDC1 is a key protein in DNA damage signaling. When DNA double-strand breaks (DSBs) occur, MDC1 localizes to sites of damage to promote the recruitment of other factors, including the 53BP1-mediated DSB repair pathway. By studying mechanisms of poly(ADP-ribose) polymerase inhibitor (PARPi) resistanc...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Liptay, Martin, Barbosa, Joana S., Gogola, Ewa, Duarte, Alexandra A., Dibitetto, Diego, Schmid, Jonas A., Klebic, Ismar, Mutlu, Merve, Siffert, Myriam, Francica, Paola, Salguero, Israel, van de Ven, Marieke, Korte-Grimmerink, Renske de, Jackson, Stephen P., Jonkers, Jos, Lopes, Massimo, Rottenberg, Sven
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Laboratory 19.08.2022
Edition:	1.1
Subjects:	Molecular Biology
ISSN:	2692-8205
Online Access:	Get full text
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