H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs)1,2. In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitment of the DNA repair effectors 53BP1 and BRCA13–6. Here, b...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Dibitetto, Diego, Liptay, Martin, Vivalda, Francesca, Gogola, Ewa, Dogan, Hulya, Fernández, Martín G., Duarte, Alexandra, Schmid, Jonas A., Durant, Stephen T., Forment, Josep V., Klebic, Ismar, Siffert, Myriam, de Bruijn, Roebi, Kousholt, Arne N., Marti, Nicole A., Dettwiler, Martina, Sørensen, Claus S., Lopes, Massimo, Sartori, Alessandro A., Jonkers, Jos, Rottenberg, Sven
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Laboratory 24.05.2023
Edition:	1.1
Subjects:	Cancer Biology
ISSN:	2692-8205
Online Access:	Get full text
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