Melatonin: Pharmacology, Functions and Therapeutic Benefits

Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore ad...

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Vydáno v:Current neuropharmacology Ročník 15; číslo 3; s. 434
Hlavní autoři: Tordjman, Sylvie, Chokron, Sylvie, Delorme, Richard, Charrier, Annaëlle, Bellissant, Eric, Jaafari, Nemat, Fougerou, Claire
Médium: Journal Article
Jazyk:angličtina
Vydáno: United Arab Emirates 01.04.2017
Témata:
Animals
Antioxidants - pharmacology
Antioxidants - therapeutic use
Brain - drug effects
Brain - metabolism
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
Humans
Melatonin - pharmacology
Melatonin - therapeutic use
Mental Disorders - drug therapy
sleep-wake rhythm
biological clocks
clinical application
synchronizer
prevention and treatment
Adaptation to external and internal environment
biomarker
melatonin
central and peripheral oscillators
ISSN:1875-6190, 1875-6190
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Shrnutí:Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock. First, the pharmacology of melatonin (biosynthesis and circadian rhythms, pharmacokinetics and mechanisms of action) is described, allowing a better understanding of the short and long term effects of melatonin following its immediate or prolonged release. Then, research related to the physiological effects of melatonin is reviewed. The physiological effects of melatonin are various and include detoxification of free radicals and antioxidant actions, bone formation and protection, reproduction, and cardiovascular, immune or body mass regulation. Also, protective and therapeutic effects of melatonin are reported, especially with regard to brain or gastrointestinal protection, psychiatric disorders, cardiovascular diseases and oncostatic effects. This review highlights the high number and diversity of major melatonin effects and opens important perspectives for measuring melatonin as a biomarker (biomarker of early identification of certain disorders and also biomarker of their follow-up) and using melatonin with clinical preventive and therapeutic applications in newborns, children and adults based on its physiological regulatory effects.
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ISSN:1875-6190
1875-6190
DOI:10.2174/1570159X14666161228122115