E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT
Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that is relevant to LS pa...
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| Vydáno v: | Nature communications |
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Cold Spring Harbor Laboratory
02.10.2024
Nature Publishing Group |
| Vydání: | 1.2 |
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| ISSN: | 2041-1723, 2692-8205, 2041-1723 |
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| Abstract | Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that is relevant to LS pathogenesis. We identified the transcription factor E4F1 as a key coordinator of AcetylCoenzyme A (AcCoA) production by the pyruvate dehydrogenase complex (PDC) and its utilization as an essential co-factor by the Elongator complex to acetylate tRNAs at the wobble position uridine 34 (U34). E4F1-mediated direct transcriptional regulation of Dlat and Elp3, two genes encoding key subunits of the PDC and of the Elongator complex, respectively, ensured proper translation fidelity and cell survival in the central nervous system (CNS) during mouse embryonic development. Furthermore, analysis of PDH-deficient cells highlighted a crosstalk linking the PDC to ELP3 expression that is perturbed in LS patients. |
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| AbstractList | Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that is relevant to LS pathogenesis. We identified the transcription factor E4F1 as a key coordinator of AcetylCoenzyme A (AcCoA) production by the pyruvate dehydrogenase complex (PDC) and its utilization as an essential co-factor by the Elongator complex to acetylate tRNAs at the wobble position uridine 34 (U34). E4F1-mediated direct transcriptional regulation of Dlat and Elp3, two genes encoding key subunits of the PDC and of the Elongator complex, respectively, ensured proper translation fidelity and cell survival in the central nervous system (CNS) during mouse embryonic development. Furthermore, analysis of PDH-deficient cells highlighted a crosstalk linking the PDC to ELP3 expression that is perturbed in LS patients. SUMMARY Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that is relevant to LS pathogenesis. We identified the transcription factor E4F1 as a key coordinator of AcetylCoenzyme A (AcCoA) production by the pyruvate dehydrogenase complex (PDC) and its utilization as an essential co-factor by the Elongator complex to acetylate tRNAs at the wobble position uridine 34 (U 34 ). E4F1-mediated direct transcriptional regulation of Dlat and Elp3 , two genes encoding key subunits of the PDC and of the Elongator complex, respectively, ensured proper translation fidelity and cell survival in the central nervous system (CNS) during mouse embryonic development. Furthermore, analysis of PDH-deficient cells highlighted a crosstalk linking the PDC to ELP3 expression that is perturbed in LS patients. |
| Author | Claude, Sardet Nelly, Pirot Lucille, Stuani Mélanie, Rousseau Yoan, Buscail Pierre, Close Laurent, Le Cam Michela, Di Michele Laura, Papon Aurore, Attina Pierre-François, Roux Pierrick, Dupré Betty, Encislai Justine, Guégan Javier, Florido Hugo, Mathieu Lucie, Rubio Daniele, Ghezzi Tania, Sorg Carole, Ferraro Peyret Vincent, Compan Céline, Jahanault-Tagliani Adeline, Torro Alexandre, David Giuseppe, Arena Sophie, Laguesse Christophe, Hirtz Morane, Houdeville Francesca, Rapino Geneviève, Rodier Hanna, Kulyk Armelle, Choquet Floriant, Bellvert Cédric, Chaveroux Elise, Lebigot Olivia, Wendling Andrea, Legati Imène, Tabet Matthieu, Lacroix Maryse, Fuentes Henri-Alexandre, Michaud Laurent, Nguyen Carlo, De Blasio Francois-Xavier, Frenois Fabrice, Ango |
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| Cites_doi | 10.1016/j.bbagrm.2017.11.006 10.1016/j.cell.2014.04.046 10.1038/s41586-018-0243-7 10.1038/s41588-017-0026-3 10.1371/journal.pone.0089020 10.1016/j.cmet.2024.05.002 10.3390/ijms21218209 10.1038/s41467-021-22254-5 10.1126/scitranslmed.aan0457 10.1093/hmg/ddr393 10.1016/j.cmet.2024.07.022 |
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| Keywords | pyruvate metabolism translation Leigh syndrome E4F1 Elongator complex integrated stress response |
| Language | English |
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| Notes | Competing Interest Statement: The authors have declared no competing interest. |
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| References | Nitsch, Zorro Shahidian, Schneider (2022.12.19.521032v2.35) 2021; 22 Sun, Zhang, Gao (2022.12.19.521032v2.34) 2021 Moutin (2022.12.19.521032v2.43) 2020; 30 Storbeck (2022.12.19.521032v2.33) 2014; 9 Morscher (2022.12.19.521032v2.38) 2018; 554 Buske, Bodén, Bauer, Bailey (2022.12.19.521032v2.45) 2010; 26 Winkler, Kristjuhan, Erdjument-Bromage, Tempst, Svejstrup (2022.12.19.521032v2.26) 2002; 99 Marin-Valencia (2022.12.19.521032v2.31) 2024; 36 Anderl, Freeland, Kwiatkowski, Goto (2022.12.19.521032v2.32) 2011; 20 Perry (2022.12.19.521032v2.39) 2021; 3 Chen (2022.12.19.521032v2.20) 2018; 50 Petrakis, Wittschieben, Svejstrup (2022.12.19.521032v2.23) 2004; 279 Mohun, Weninger (2022.12.19.521032v2.47) 2012 Rodier (2022.12.19.521032v2.7) 2015; 11 Jain (2022.12.19.521032v2.41) 2016; 352 Le Cam (2022.12.19.521032v2.4) 2006; 127 Lacroix (2022.12.19.521032v2.8) 2016; 113 Creppe (2022.12.19.521032v2.25) 2009; 136 Jakkamsetti (2022.12.19.521032v2.30) 2020; 11 Rapino (2022.12.19.521032v2.27) 2018; 558 Muzumdar, Tasic, Miyamichi, Li, Luo (2022.12.19.521032v2.17) 2007; 45 Lee, Caudal, Abell, Gowda, Tian (2022.12.19.521032v2.42) 2019; 9 Houlès, Rodier, Le Cam, Sardet, Kirsh (2022.12.19.521032v2.22) 2015; 14 Fajas (2022.12.19.521032v2.46) 2000; 97 Batnini (2022.12.19.521032v2.10) 2022; 23 Rapino (2022.12.19.521032v2.28) 2021; 12 Hetz, Zhang, Kaufman (2022.12.19.521032v2.29) 2020; 21 Goncalves (2022.12.19.521032v2.1) 2020; 40 Morrison (2022.12.19.521032v2.36) 2022; 289 Wendling (2022.12.19.521032v2.48) 2021; 9 Legati (2022.12.19.521032v2.11) 2016; 1857 Hermand (2022.12.19.521032v2.14) 2020; 4 Tronche (2022.12.19.521032v2.15) 1999; 23 Le Cam, Lacroix, Ciemerych, Sardet, Sicinski (2022.12.19.521032v2.16) 2004; 24 Bakare, Lesnefsky, Lyer (2022.12.19.521032v2.2) 2021; 12 Laguesse (2022.12.19.521032v2.21) 2015; 35 Biffo, Ruggero, Santoro (2022.12.19.521032v2.37) 2024; 36 Lin (2022.12.19.521032v2.12) 2019; 10 Rizos (2022.12.19.521032v2.6) 2003; 278 Sutendra (2022.12.19.521032v2.19) 2014; 158 Lacroix (2022.12.19.521032v2.18) 2010; 107 Ewels (2022.12.19.521032v2.44) 2020; 38 Johnson (2022.12.19.521032v2.40) 2013; 342 Johansson, Xu (2022.12.19.521032v2.24) 2018; 1861 Raychaudhuri (2022.12.19.521032v2.3) 1987; 6 Abbassi, Biela, Glatt, Lin (2022.12.19.521032v2.13) 2020; 21 Fajas (2022.12.19.521032v2.5) 2001; 21 Goguet-Rubio (2022.12.19.521032v2.9) 2016; 113 |
| References_xml | – start-page: 1 year: 2021 end-page: 43 ident: 2022.12.19.521032v2.34 article-title: Metabolic reprogramming and epigenetic modifications on the path to cancer publication-title: Protein & Cell – volume: 279 start-page: 32087 year: 2004 end-page: 32092 ident: 2022.12.19.521032v2.23 article-title: Molecular Architecture, Structure-Function Relationship, and Importance of the Elp3 Subunit for the RNA Binding of Holo-Elongator publication-title: J. Biol. Chem – volume: 30 start-page: 12/19 year: 2020 ident: 2022.12.19.521032v2.43 article-title: Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons publication-title: Front Synaptic Neurosci – volume: 107 start-page: 21076 year: 2010 end-page: 21081 ident: 2022.12.19.521032v2.18 article-title: Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis publication-title: Proc. Natl. Acad. Sci. U.S.A – volume: 21 start-page: 2956 year: 2001 end-page: 2966 ident: 2022.12.19.521032v2.5 article-title: Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1 publication-title: Mol. Cell. Biol – volume: 342 start-page: 1524 year: 2013 end-page: 1528 ident: 2022.12.19.521032v2.40 article-title: mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome publication-title: Science – volume: 127 start-page: 775 year: 2006 end-page: 788 ident: 2022.12.19.521032v2.4 article-title: E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation publication-title: Cell – volume: 136 start-page: 551 year: 2009 end-page: 564 ident: 2022.12.19.521032v2.25 article-title: Elongator Controls the Migrationand Differentiation of Cortical Neurons through Acetylation of a-Tubulin publication-title: Cell – volume: 1861 start-page: 401 issue: 4 year: 2018 end-page: 408 ident: 2022.12.19.521032v2.24 article-title: Elongator-a tRNA modifying complex that promotes efficient translational decoding publication-title: Biochim Biophys Acta Gene Regul Mech doi: 10.1016/j.bbagrm.2017.11.006 – volume: 23 start-page: 99 year: 1999 end-page: 103 ident: 2022.12.19.521032v2.15 article-title: Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety publication-title: Nat Genet – volume: 158 start-page: 84 issue: 1 year: 2014 end-page: 97 ident: 2022.12.19.521032v2.19 article-title: A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation publication-title: Cell doi: 10.1016/j.cell.2014.04.046 – volume: 289 start-page: 1302 year: 2022 end-page: 1314 ident: 2022.12.19.521032v2.36 article-title: Cancer cell metabolism connects epigenetic modifications to transcriptional regulation publication-title: FEBS J – volume: 4 start-page: 7 issue: 2 year: 2020 ident: 2022.12.19.521032v2.14 article-title: Anticodon Wobble Uridine Modification by Elongator at the Crossroad of Cell Signaling publication-title: Differentiation, and Diseases. Epigenomes – volume: 21 start-page: 421 year: 2020 end-page: 438 ident: 2022.12.19.521032v2.29 article-title: Mechanisms, regulation and functions of the unfolded protein response publication-title: Nat Rev Mol Cell Biol – volume: 45 start-page: 593 year: 2007 end-page: 605 ident: 2022.12.19.521032v2.17 article-title: A global double-fluorescent Cre reporter mouse publication-title: Genesis – volume: 558 start-page: 605 issue: 7711 year: 2018 end-page: 609 ident: 2022.12.19.521032v2.27 article-title: Codon-specific translation reprogramming promotes resistance to targeted therapy publication-title: Nature doi: 10.1038/s41586-018-0243-7 – volume: 97 start-page: 7738 year: 2000 end-page: 7743 ident: 2022.12.19.521032v2.46 article-title: pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F publication-title: Proc. Natl. Acad. Sci. U.S.A – volume: 10 start-page: 625 issue: 1 year: 2019 ident: 2022.12.19.521032v2.12 article-title: The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase publication-title: Nat Comm – volume: 40 start-page: 2042 issue: 7 year: 2020 end-page: 2067 ident: 2022.12.19.521032v2.1 article-title: Primary mitochondrial disorders of the pediatric central nervous system: neuroimaging findings publication-title: Radiographics – volume: 113 start-page: 10998 issue: 39 year: 2016 end-page: 1003 ident: 2022.12.19.521032v2.8 article-title: E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity publication-title: Proc Natl Acad Sci U S A – volume: 9 start-page: 767 issue: 7 year: 2021 ident: 2022.12.19.521032v2.48 article-title: High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New “Histo3D” System publication-title: Biomedicines – volume: 12 start-page: 693734 year: 2021 ident: 2022.12.19.521032v2.2 article-title: Leigh Syndrome: A Tale of Two Genomes publication-title: Front Physiol – volume: 50 start-page: 219 issue: 2 year: 2018 end-page: 228 ident: 2022.12.19.521032v2.20 article-title: Compartimentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer publication-title: Nat Genet doi: 10.1038/s41588-017-0026-3 – volume: 14 start-page: 368 issue: 5 year: 2015 end-page: 70 ident: 2022.12.19.521032v2.22 article-title: Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs publication-title: Genomics Data – volume: 9 start-page: e89020 issue: 2 year: 2014 ident: 2022.12.19.521032v2.33 article-title: Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain publication-title: PLoS One doi: 10.1371/journal.pone.0089020 – volume: 22 start-page: e52774 issue: 7 year: 2021 ident: 2022.12.19.521032v2.35 article-title: Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism publication-title: EMBO Rep – volume: 99 start-page: 3517 year: 2002 end-page: 3522 ident: 2022.12.19.521032v2.26 article-title: Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo publication-title: Proc. Natl. Acad. Sci. U.S.A – volume: 11 start-page: 220 year: 2015 end-page: 233 ident: 2022.12.19.521032v2.7 article-title: The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions publication-title: Cell Reports – volume: 23 start-page: 9217 issue: 16 year: 2022 ident: 2022.12.19.521032v2.10 article-title: Multi-level control of the ATM/ATR-CHK1 axis by the transcription factor E4F1 in triple negative breast cancer publication-title: Int J Mol Sci – volume: 6 start-page: 4073 year: 1987 end-page: 4081 ident: 2022.12.19.521032v2.3 article-title: Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter publication-title: EMBO J – volume: 36 start-page: 1394 issue: 6 year: 2024 end-page: 1410 ident: 2022.12.19.521032v2.31 article-title: Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency publication-title: Cell Metab doi: 10.1016/j.cmet.2024.05.002 – volume: 21 year: 2020 ident: 2022.12.19.521032v2.13 article-title: How Elongator Acetylates tRNA Bases publication-title: IJMS doi: 10.3390/ijms21218209 – volume: 12 start-page: 2170 issue: 1 year: 2021 ident: 2022.12.19.521032v2.28 article-title: Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate publication-title: Nat Comm doi: 10.1038/s41467-021-22254-5 – volume: 11 start-page: eaan0457 issue: 480 year: 2020 ident: 2022.12.19.521032v2.30 article-title: Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency publication-title: Sci Trans Med doi: 10.1126/scitranslmed.aan0457 – volume: 9 start-page: 3073 issue: 1 year: 2019 ident: 2022.12.19.521032v2.42 article-title: Targeting NAD+ metabolism as interventions for mitochondrial disease publication-title: Sci. Rep – volume: 20 start-page: 4597 issue: 23 year: 2011 end-page: 604 ident: 2022.12.19.521032v2.32 article-title: Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex publication-title: Hum Mol Genet doi: 10.1093/hmg/ddr393 – volume: 554 start-page: 128 year: 2018 end-page: 132 ident: 2022.12.19.521032v2.38 article-title: Mitochondrial translation requires folate-dependent tRNA methylation publication-title: Nature – volume: 35 start-page: 553 year: 2015 end-page: 567 ident: 2022.12.19.521032v2.21 article-title: A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis publication-title: Developmental Cell – volume: 352 start-page: 54 year: 2016 end-page: 61 ident: 2022.12.19.521032v2.41 article-title: Hypoxia as a therapy for mitochondrial disease publication-title: Science – start-page: 678 year: 2012 end-page: 680 ident: 2022.12.19.521032v2.47 article-title: Embedding embryos for high-resolution episcopic microscopy (HREM) publication-title: Cold Spring Harb Protoc – volume: 278 start-page: 4981 year: 2003 end-page: 4989 ident: 2022.12.19.521032v2.6 article-title: Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition publication-title: J. Biol. Chem – volume: 1857 start-page: 1326 issue: 8 year: 2016 end-page: 1335 ident: 2022.12.19.521032v2.11 article-title: New genes and pathomechanisms in mitochondrial disorders unraveled by NGS technologies publication-title: Biochimica et Biophysica Acta. BBA - Bioenergetics – volume: 3 start-page: 33 issue: 1 year: 2021 end-page: 42 ident: 2022.12.19.521032v2.39 article-title: Tetracyclines promote survival and fitness in mitochondrial disease models publication-title: Nature Metabolism – volume: 38 start-page: 276 issue: 3 year: 2020 end-page: 278 ident: 2022.12.19.521032v2.44 article-title: The nf-core framework for community-curated bioinformatics pipelines publication-title: Nat Biotechnol – volume: 113 start-page: 11004 issue: 39 year: 2016 end-page: 9 ident: 2022.12.19.521032v2.9 article-title: E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis publication-title: Proc Natl Acad Sci U S A – volume: 24 start-page: 6467 year: 2004 end-page: 6475 ident: 2022.12.19.521032v2.16 article-title: The E4F protein is required for mitotic progression during embryonic cell cycles publication-title: Mol. Cell. Biol – volume: 36 start-page: 1945 issue: 9 year: 2024 end-page: 1962 ident: 2022.12.19.521032v2.37 article-title: The crosstalk between metabolism and translation publication-title: Cell Metab doi: 10.1016/j.cmet.2024.07.022 – volume: 26 start-page: 860 issue: 7 year: 2010 end-page: 866 ident: 2022.12.19.521032v2.45 article-title: Assigning roles to DNA regulatory motifs using comparative genomics publication-title: Bioinformatics |
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| Snippet | Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain... SUMMARY Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death... |
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| Title | E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT |
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