Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19

Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects o...

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Vydáno v:bioRxiv
Hlavní autoři: Wilk, Aaron J, Rustagi, Arjun, Zhao, Nancy Q, Martin, Beth A, Rogers, Angela J, Blish, Catherine A
Médium: Paper
Jazyk:angličtina
Vydáno: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.10.2020
Cold Spring Harbor Laboratory
Vydání:1.1
Témata:
Coronaviruses
COVID-19
Immune response
Immunology
Leukocytes (neutrophilic)
ISSN:2692-8205, 2692-8205
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Shrnutí:Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects of their criticism of our analysis to be problematic. Here we respond briefly to misunderstandings and inaccuracies in their commentary that may have led to misinformed interpretation of our results. Competing Interest Statement The authors have declared no competing interest.
Bibliografie:SourceType-Working Papers-1
ObjectType-Working Paper/Pre-Print-1
content type line 50
Competing Interest Statement: The authors have declared no competing interest.
ISSN:2692-8205
2692-8205
DOI:10.1101/2020.10.15.339473