Traditional uses and pharmacological activities of Tetracera alnifolia (Wild) Drake

Ethnopharmacological relevance: Tetracera alnifolia (Wild) Drake, is well used in traditional Guinean medicine for the treatment of infectious skin diseases. The present aim was to contribute to the valorization of Tetracera alnifolia leaves, focused on ethnomedical, biological and phytochemical inv...

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Vydáno v:bioRxiv
Hlavní autoři: Camara, Aboubacar Kadiatou, Elhadj Saidou Balde, Mamadou Saliou Telly Diallo, Camara, Mohamed Kerfalla, Tanou Valdez Bah, Conde, Mamoudou, Soumah, Aboubacar, Tietjen, Ian, Balde, Aliou Mamadou
Médium: Paper
Jazyk:angličtina
Vydáno: Cold Spring Harbor Cold Spring Harbor Laboratory Press 08.02.2024
Cold Spring Harbor Laboratory
Vydání:1.1
Témata:
Chloroform
Dichloromethane
HIV
Human immunodeficiency virus
Malnutrition
Minimum inhibitory concentration
Pharmacology and Toxicology
Severe acute respiratory syndrome coronavirus 2
Skin diseases
Protozoa
SARS-CoV-2
Ethnomedical Investigations
Biological Activity
ISSN:2692-8205, 2692-8205
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Shrnutí:Ethnopharmacological relevance: Tetracera alnifolia (Wild) Drake, is well used in traditional Guinean medicine for the treatment of infectious skin diseases. The present aim was to contribute to the valorization of Tetracera alnifolia leaves, focused on ethnomedical, biological and phytochemical investigations. Materials and methods: we conducted an ethnomedical survey across several markets of the city of Conakry to identify 39 healers. Chloroform, methanol, dichloromethane, and aqueous extracts were tested for activities against protozoa, bacteria, fungi, HIV, and SARS-CoV-2. Results: the traditional healers indicated that T. alnifolia is used in the treatment of more than 15 pathologies including Fassa (marasmus/malnutrition), Soukhou kouye (white discharge in women), and Temou bankhi (sexual weakness in men). Leaves were the most used part. The modes of preparation included decoction and powder. Data from biological activities identicatied good activities of the methanolic extract against Leishmania infantum (MIC = 8.11 μg / ml) and a moderate activity on Trypanosoma brucei (MIC = 28.15 μg / ml) and Staphylococcus aureus (MIC = 29.91 μg/ ml), while dichloromethane extracts acted on live SARS-CoV-2 replication with up to 53.4% inhibition at 50 μg/mL. Conclusion: these results explain at least in part the traditional use of T. alnifoliaCompeting Interest StatementThe authors have declared no competing interest.
Bibliografie:SourceType-Working Papers-1
ObjectType-Working Paper/Pre-Print-1
content type line 50
Competing Interest Statement: The authors have declared no competing interest.
ISSN:2692-8205
2692-8205
DOI:10.1101/2024.02.07.579282