Asthma-associated variants induce IL33 differential expression through a novel regulatory region

ABSTRACT Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as a strong regulatory element in vivo and in vitro. Chromatin conformation capture showed...

Celý popis

Podrobná bibliografia

Vydané v:	bioRxiv
Hlavní autori:	Aneas, Ivy, Decker, Donna C, Howard, Chanie L, Sobreira, Débora R, Sakabe, Noboru J, Blaine, Kelly M, Stein, Michelle M, Hrusch, Cara L, Montefiori, Lindsey E, Tena, Juan, Magnaye, Kevin M, Clay, Selene M, Gern, James E, Jackson, Daniel J, Altman, Matthew C, Naureckas, Edward T, Hogarth, Douglas K, White, Steven R, Gomez-Skarmeta, Jose Luis, Schoetler, Nathan, Ober, Carole, Sperling, Anne I, Nobrega, Marcelo A
Médium:	Paper
Jazyk:	English
Vydavateľské údaje:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.09.2020 Cold Spring Harbor Laboratory
Vydanie:	1.1
Predmet:	Alleles Asthma Chromatin Epithelial cells Gene expression Genome-wide association studies Genomes Genomics Genotypes Oct-1 protein Single-nucleotide polymorphism
ISSN:	2692-8205, 2692-8205
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!