Asthma-associated variants induce IL33 differential expression through a novel regulatory region

ABSTRACT Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as a strong regulatory element in vivo and in vitro. Chromatin conformation capture showed...

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Veröffentlicht in:	bioRxiv
Hauptverfasser:	Aneas, Ivy, Decker, Donna C, Howard, Chanie L, Sobreira, Débora R, Sakabe, Noboru J, Blaine, Kelly M, Stein, Michelle M, Hrusch, Cara L, Montefiori, Lindsey E, Tena, Juan, Magnaye, Kevin M, Clay, Selene M, Gern, James E, Jackson, Daniel J, Altman, Matthew C, Naureckas, Edward T, Hogarth, Douglas K, White, Steven R, Gomez-Skarmeta, Jose Luis, Schoetler, Nathan, Ober, Carole, Sperling, Anne I, Nobrega, Marcelo A
Format:	Paper
Sprache:	Englisch
Veröffentlicht:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.09.2020 Cold Spring Harbor Laboratory
Ausgabe:	1.1
Schlagworte:	Alleles Asthma Chromatin Epithelial cells Gene expression Genome-wide association studies Genomes Genomics Genotypes Oct-1 protein Single-nucleotide polymorphism
ISSN:	2692-8205, 2692-8205
Online-Zugang:	Volltext
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