Regional brain atrophy and functional disconnection across Alzheimer's disease evolution
ObjectiveTo assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.MethodsTen patients with amnesic mild cognitive impairment (a-MCI), 11 patie...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry Jg. 82; H. 1; S. 58 - 66 |
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| Hauptverfasser: | , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
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BMJ Publishing Group Ltd
01.01.2011
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| ISSN: | 0022-3050, 1468-330X, 1468-330X |
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| Abstract | ObjectiveTo assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.MethodsTen patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis.ResultsCompared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD.ConclusionsThis study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD. |
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| AbstractList | ObjectiveTo assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.MethodsTen patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis.ResultsCompared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD.ConclusionsThis study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD. Objective To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages. Methods Ten patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis. Results Compared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD. Conclusions This study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD. To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages. Ten patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis. Compared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD. This study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD. To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.OBJECTIVETo assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.Ten patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis.METHODSTen patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis.Compared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD.RESULTSCompared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD.This study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD.CONCLUSIONSThis study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD. Objective: to assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages. Methods Ten patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD, and 10 healthy controls were recruited. T1-volumes were obtained from each subject and post-processed according to an optimized voxel based morphometry protocol. Resting-state functional MRI data were also collected from the same individuals, and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis (ICA). Results: Compared to healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex (mPFC) and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD. Conclusions: This study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflect a long-term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD. |
| Author | Cercignani, M Bozzali, M Caltagirone, C Maraviglia, B Gili, T Perri, R Serra, L Giove, F |
| Author_xml | – sequence: 1 givenname: T surname: Gili fullname: Gili, T email: m.bozzali@hsantalucia.it organization: Neuroimaging Laboratory, Santa Lucia Foundation, IRCCS, Rome, Italy – sequence: 2 givenname: M surname: Cercignani fullname: Cercignani, M email: m.bozzali@hsantalucia.it organization: Neuroimaging Laboratory, Santa Lucia Foundation, IRCCS, Rome, Italy – sequence: 3 givenname: L surname: Serra fullname: Serra, L email: m.bozzali@hsantalucia.it organization: Neuroimaging Laboratory, Santa Lucia Foundation, IRCCS, Rome, Italy – sequence: 4 givenname: R surname: Perri fullname: Perri, R email: m.bozzali@hsantalucia.it organization: Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, IRCCS, Rome, Italy – sequence: 5 givenname: F surname: Giove fullname: Giove, F email: m.bozzali@hsantalucia.it organization: Marbilab, Enrico Fermi Centre, Rome, Italy – sequence: 6 givenname: B surname: Maraviglia fullname: Maraviglia, B email: m.bozzali@hsantalucia.it organization: Marbilab, Enrico Fermi Centre, Rome, Italy – sequence: 7 givenname: C surname: Caltagirone fullname: Caltagirone, C email: m.bozzali@hsantalucia.it organization: Department of Neuroscience, University of Rome ‘Tor Vergata', Rome, Italy – sequence: 8 givenname: M surname: Bozzali fullname: Bozzali, M email: m.bozzali@hsantalucia.it organization: Neuroimaging Laboratory, Santa Lucia Foundation, IRCCS, Rome, Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23711111$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20639384$$D View this record in MEDLINE/PubMed https://hal.science/hal-00557437$$DView record in HAL |
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| ContentType | Journal Article |
| Copyright | 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. 2015 INIST-CNRS Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. – notice: 2015 INIST-CNRS – notice: Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. – notice: Distributed under a Creative Commons Attribution 4.0 International License |
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| DOI | 10.1136/jnnp.2009.199935 |
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| Keywords | Atrophy Nervous system diseases Alzheimer disease Central nervous system disease Central nervous system Evolution Degenerative disease Cerebral disorder Encephalon ALZHEIMER'S DISEASE DEMENTIA COGNITION DISCONNECTION IMAGE ANALYSIS |
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| SubjectTerms | Aged Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Amnesia - pathology Amnesia - psychology Atrophy Biological and medical sciences Brain Brain - pathology Cognition Disorders - pathology Cognition Disorders - psychology Cognitive ability Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Disease Progression Female Fourier transforms Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical sciences Memory Middle Aged Nerve Net - pathology Neural Pathways - pathology Neurology Neuropsychological Tests Neuropsychology |
| Title | Regional brain atrophy and functional disconnection across Alzheimer's disease evolution |
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