High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

ObjectiveA comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased char...

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Bibliographic Details
Published in:	Gut Vol. 69; no. 4; pp. 691 - 703
Main Authors:	de Vries, Natasja L, van Unen, Vincent, Ijsselsteijn, Marieke E, Abdelaal, Tamim, van der Breggen, Ruud, Farina Sarasqueta, Arantza, Mahfouz, Ahmed, Peeters, Koen C M J, Höllt, Thomas, Lelieveldt, Boudewijn P F, Koning, Frits, de Miranda, Noel F C C
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2020 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original research
Subjects:	Antibodies Antigens, CD - metabolism Cancer Cancer immunotherapy Cancer therapies Case-Control Studies CD103 antigen CD38 antigen CD56 antigen CD69 antigen CD7 antigen CD8 Antigens - metabolism Cells Clustering Colon Colonic Neoplasms - immunology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma Cytotoxicity Flow Cytometry Genomics GI cancer Histocompatibility antigen HLA Humans immune landscape Immunity Immunofluorescence Immunogenicity Immunoglobulins Immunotherapy innate lymphoid cells Integrin alpha Chains - metabolism Lymph nodes Lymphatic system Lymphocyte Count Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating mass cytometry Medical research Metastases Mismatch repair Mucosa Mutation Patients PD-1 protein Peripheral blood Phenotypes Principal components analysis Ribonucleic acid RNA single-cell immunophenotyping tissue-resident memory T cells Transcription Tumors Netherlands immune landscape colorectal cancer single-cell immunophenotyping innate lymphoid cells mass cytometry tissue-resident memory T cells
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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