Biological activity of neosergeolide and isobrucein B (and two semi-synthetic derivatives) isolated from the Amazonian medicinal plant Picrolemma sprucei (Simaroubaceae)

In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). The...

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Bibliographic Details
Published in:	Memórias do Instituto Oswaldo Cruz Vol. 104; no. 1; pp. 48 - 56
Main Authors:	Silva, Ellen CC, Cavalcanti, Bruno C, Amorim, Rodrigo CN, Lucena, Jorcilene F, Quadros, Dulcimar S, Tadei, Wanderli P, Montenegro, Raquel C, Costa-Lotufo, Letícia V, Pessoa, Cláudia, Moraes, Manoel O, Nunomura, Rita CS, Nunomura, Sergio M, Melo, Marcia RS, de Andrade-Neto, Valter F, Silva, Luiz Francisco R, Vieira, Pedro Paulo R, Pohlit, Adrian M
Format:	Journal Article
Language:	English
Published:	Brazil Fundação Oswaldo Cruz, Fiocruz 01.02.2009 Instituto Oswaldo Cruz, Ministério da Saúde Fundação Oswaldo Cruz (FIOCRUZ)
Subjects:	1,12-diacetylisobrucein B 12-acetylneosergeolide Aedes - drug effects Aedes aegypti Animals antimalarial Artemia - drug effects Artemia franciscana cytotoxicity Erythrocytes - drug effects Hemolysis - drug effects HL-60 Cells - drug effects Humans isobrucein B larvicide Lethal Dose 50 Mice neosergeolide neosergeolide - isobrucein B - 12-acetylneosergeolide - 1,12-diacetylisobrucein B - cytotoxicity - antimalarial - larvicide PARASITOLOGY Plants, Medicinal Plasmodium falciparum Plasmodium falciparum - drug effects Quassins - isolation & purification Quassins - pharmacology Simaroubaceae Simaroubaceae - chemistry TROPICAL MEDICINE 12-acetylneosergeolide 1,12-diacetylisobrucein B isobrucein B antimalarial neosergeolide cytotoxicity larvicide
ISSN:	1678-8060, 0074-0276, 0074-0276, 1678-8060
Online Access:	Get full text
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