Biological activity of neosergeolide and isobrucein B (and two semi-synthetic derivatives) isolated from the Amazonian medicinal plant Picrolemma sprucei (Simaroubaceae)
In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). The...
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| Published in: | Memórias do Instituto Oswaldo Cruz Vol. 104; no. 1; pp. 48 - 56 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Brazil
Fundação Oswaldo Cruz, Fiocruz
01.02.2009
Instituto Oswaldo Cruz, Ministério da Saúde Fundação Oswaldo Cruz (FIOCRUZ) |
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| ISSN: | 1678-8060, 0074-0276, 0074-0276, 1678-8060 |
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| Abstract | In the present study, in vitro techniques were used to investigate a
range of biological activities of known natural quassinoids isobrucein
B (1) and neosergeolide (2), known semi-synthetic derivative
1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative,
12-acetylneosergeolide (4). These compounds were evaluated for general
toxicity toward the brine shrimp species Artemia franciscana,
cytotoxicity toward human tumour cells, larvicidal activity toward the
dengue fever mosquito vector Aedes aegypti , haemolytic activity in
mouse erythrocytes and antimalarial activity against the human malaria
parasite Plasmodium falciparum . Compounds 1 and 2 exhibited the
greatest cytotoxicity against all the tumor cells tested (IC50 = 5-27
µg/L) and against multidrug-resistant P. falciparum K1 strain
(IC50 = 1.0-4.0 g/L) and 3 was only cytotoxic toward the leukaemia
HL-60 strain (IC50 = 11.8 µg/L). Quassinoids 1 and 2 (LC50 =
3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC50 =
75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive.
These results suggest a novel application for these natural quassinoids
as larvicides. The toxicity toward A. franciscana could be correlated
with the activity in several biological models, a finding that is in
agreement with the literature. Importantly, none of the studied
compounds exhibited in vitro haemolytic activity, suggesting
specificity of the observed cytotoxic effects. This study reveals the
biological potential of quassinoids 1 and 2 and to a lesser extent
their semi-synthetic derivatives for their in vitro antimalarial and
cytotoxic activities. |
|---|---|
| AbstractList | In the present study, in vitro techniques were used to investigate a
range of biological activities of known natural quassinoids isobrucein
B (1) and neosergeolide (2), known semi-synthetic derivative
1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative,
12-acetylneosergeolide (4). These compounds were evaluated for general
toxicity toward the brine shrimp species Artemia franciscana,
cytotoxicity toward human tumour cells, larvicidal activity toward the
dengue fever mosquito vector Aedes aegypti , haemolytic activity in
mouse erythrocytes and antimalarial activity against the human malaria
parasite Plasmodium falciparum . Compounds 1 and 2 exhibited the
greatest cytotoxicity against all the tumor cells tested (IC50 = 5-27
µg/L) and against multidrug-resistant P. falciparum K1 strain
(IC50 = 1.0-4.0 g/L) and 3 was only cytotoxic toward the leukaemia
HL-60 strain (IC50 = 11.8 µg/L). Quassinoids 1 and 2 (LC50 =
3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC50 =
75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive.
These results suggest a novel application for these natural quassinoids
as larvicides. The toxicity toward A. franciscana could be correlated
with the activity in several biological models, a finding that is in
agreement with the literature. Importantly, none of the studied
compounds exhibited in vitro haemolytic activity, suggesting
specificity of the observed cytotoxic effects. This study reveals the
biological potential of quassinoids 1 and 2 and to a lesser extent
their semi-synthetic derivatives for their in vitro antimalarial and
cytotoxic activities. In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity toward human tumour cells, larvicidal activity toward the dengue fever mosquito vector Aedes aegypti, haemolytic activity in mouse erythrocytes and antimalarial activity against the human malaria parasite Plasmodium falciparum. Compounds 1 and 2 exhibited the greatest cytotoxicity against all the tumor cells tested (IC50 = 5-27 microg/L) and against multidrug-resistant P. falciparum K1 strain (IC50 = 1.0-4.0 g/L) and 3 was only cytotoxic toward the leukaemia HL-60 strain (IC50 = 11.8 microg/L). Quassinoids 1 and 2 (LC50 = 3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC50 = 75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive. These results suggest a novel application for these natural quassinoids as larvicides. The toxicity toward A. franciscana could be correlated with the activity in several biological models, a finding that is in agreement with the literature. Importantly, none of the studied compounds exhibited in vitro haemolytic activity, suggesting specificity of the observed cytotoxic effects. This study reveals the biological potential of quassinoids 1 and 2 and to a lesser extent their semi-synthetic derivatives for their in vitro antimalarial and cytotoxic activities. In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2) known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity toward human tumour cells, larvici-dal activity toward the dengue fever mosquito vector Aedes aegypti, haemolytic activity in mouse erythrocytes and antimalarial activity against the human malaria parasite Plasmodium falciparum. Compounds 1 and 2 exhibited the greatest cytotoxicity against all the tumor cells tested (IC sub(50) = 5-27 kg/L) and against multidrug-resistant P. falciparum K1 strain (IC sub(50) = 1.0-4.0 kg/L) and 3 was only cytotoxic toward the leukaemia HL-60 strain (IC sub(50) = 11.8 kg/L). Quassinoids 1 and 2 (LC sub(50) = 3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC sub(50) = 75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive. These results suggest a novel application for these natural quassinoids as larvicides. The toxicity toward A. franciscana could be correlated with the activity in several biological models, a finding that is in agreement with the literature. Importantly, none of the studied compounds exhibited in vitro haemolytic activity, suggesting specificity of the. observed cytotoxic effects. This study reveals the biological potential of quassinoids 1 and 2 and to a lesser extent their semi-synthetic derivatives for their in vitro antimalarial and cytotoxic activities. In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity toward human tumour cells, larvicidal activity toward the dengue fever mosquito vector Aedes aegypti, haemolytic activity in mouse erythrocytes and antimalarial activity against the human malaria parasite Plasmodium falciparum. Compounds 1 and 2 exhibited the greatest cytotoxicity against all the tumor cells tested (IC50 = 5-27 µg/L) and against multidrug-resistant P. falciparum K1 strain (IC50 = 1.0-4.0 g/L) and 3 was only cytotoxic toward the leukaemia HL-60 strain (IC50 = 11.8 µg/L). Quassinoids 1 and 2 (LC50 = 3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC50 = 75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive. These results suggest a novel application for these natural quassinoids as larvicides. The toxicity toward A. franciscana could be correlated with the activity in several biological models, a finding that is in agreement with the literature. Importantly, none of the studied compounds exhibited in vitro haemolytic activity, suggesting specificity of the observed cytotoxic effects. This study reveals the biological potential of quassinoids 1 and 2 and to a lesser extent their semi-synthetic derivatives for their in vitro antimalarial and cytotoxic activities. In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity toward human tumour cells, larvicidal activity toward the dengue fever mosquito vector Aedes aegypti, haemolytic activity in mouse erythrocytes and antimalarial activity against the human malaria parasite Plasmodium falciparum. Compounds 1 and 2 exhibited the greatest cytotoxicity against all the tumor cells tested (IC50 = 5-27 microg/L) and against multidrug-resistant P. falciparum K1 strain (IC50 = 1.0-4.0 g/L) and 3 was only cytotoxic toward the leukaemia HL-60 strain (IC50 = 11.8 microg/L). Quassinoids 1 and 2 (LC50 = 3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC50 = 75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive. These results suggest a novel application for these natural quassinoids as larvicides. The toxicity toward A. franciscana could be correlated with the activity in several biological models, a finding that is in agreement with the literature. Importantly, none of the studied compounds exhibited in vitro haemolytic activity, suggesting specificity of the observed cytotoxic effects. This study reveals the biological potential of quassinoids 1 and 2 and to a lesser extent their semi-synthetic derivatives for their in vitro antimalarial and cytotoxic activities.In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity toward human tumour cells, larvicidal activity toward the dengue fever mosquito vector Aedes aegypti, haemolytic activity in mouse erythrocytes and antimalarial activity against the human malaria parasite Plasmodium falciparum. Compounds 1 and 2 exhibited the greatest cytotoxicity against all the tumor cells tested (IC50 = 5-27 microg/L) and against multidrug-resistant P. falciparum K1 strain (IC50 = 1.0-4.0 g/L) and 3 was only cytotoxic toward the leukaemia HL-60 strain (IC50 = 11.8 microg/L). Quassinoids 1 and 2 (LC50 = 3.2-4.4 mg/L) displayed greater lethality than derivative 4 (LC50 = 75.0 mg/L) toward A. aegypti larvae, while derivative 3 was inactive. These results suggest a novel application for these natural quassinoids as larvicides. The toxicity toward A. franciscana could be correlated with the activity in several biological models, a finding that is in agreement with the literature. Importantly, none of the studied compounds exhibited in vitro haemolytic activity, suggesting specificity of the observed cytotoxic effects. This study reveals the biological potential of quassinoids 1 and 2 and to a lesser extent their semi-synthetic derivatives for their in vitro antimalarial and cytotoxic activities. |
| Author | Amorim, Rodrigo CN Vieira, Pedro Paulo R Quadros, Dulcimar S Cavalcanti, Bruno C Pessoa, Cláudia Montenegro, Raquel C Silva, Luiz Francisco R Pohlit, Adrian M Nunomura, Sergio M Melo, Marcia RS Lucena, Jorcilene F Tadei, Wanderli P Costa-Lotufo, Letícia V de Andrade-Neto, Valter F Moraes, Manoel O Nunomura, Rita CS Silva, Ellen CC |
| AuthorAffiliation | Fundação de Medicina Tropical Doutor Heitor Vieira Dourado Instituto Nacional de Pesquisas da Amazônia Laboratório de Princípios Ativos da Amazônia Universidade Federal do Ceará Universidade Federal do Amazonas Centro Federal de Educação Tecnológica do Amazonas Universidade Federal do Rio Grande do Norte |
| AuthorAffiliation_xml | – name: Fundação de Medicina Tropical Doutor Heitor Vieira Dourado – name: Laboratório de Princípios Ativos da Amazônia – name: Universidade Federal do Rio Grande do Norte – name: Universidade Federal do Amazonas – name: Universidade Federal do Ceará – name: Instituto Nacional de Pesquisas da Amazônia – name: Centro Federal de Educação Tecnológica do Amazonas |
| Author_xml | – sequence: 1 fullname: Silva, Ellen CC – sequence: 2 fullname: Cavalcanti, Bruno C – sequence: 3 fullname: Amorim, Rodrigo CN – sequence: 4 fullname: Lucena, Jorcilene F – sequence: 5 fullname: Quadros, Dulcimar S – sequence: 6 fullname: Tadei, Wanderli P – sequence: 7 fullname: Montenegro, Raquel C – sequence: 8 fullname: Costa-Lotufo, Letícia V – sequence: 9 fullname: Pessoa, Cláudia – sequence: 10 fullname: Moraes, Manoel O – sequence: 11 fullname: Nunomura, Rita CS – sequence: 12 fullname: Nunomura, Sergio M – sequence: 13 fullname: Melo, Marcia RS – sequence: 14 fullname: de Andrade-Neto, Valter F – sequence: 15 fullname: Silva, Luiz Francisco R – sequence: 16 fullname: Vieira, Pedro Paulo R – sequence: 17 fullname: Pohlit, Adrian M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19274376$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.4269/ajtmh.2007.77.153 10.1021/np50036a014 10.1111/j.1742-7843.2006.pto_222.x 10.1016/j.biortech.2005.10.003 10.1590/S0044-59672004000100012 10.1021/np9800304 10.1016/S0024-3205(97)00395-0 10.1016/S0006-2952(97)00155-X 10.1016/S0378-8741(00)00370-6 10.1590/1809-4392200331104 10.1590/S0074-02762007000300016 10.1016/S0223-5234(99)80067-1 10.3109/13880209309082949 10.1016/0304-3835(95)03839-O 10.1016/j.jep.2005.01.049 10.1016/S0040-4039(00)86912-9 10.1016/0022-1759(83)90303-4 10.1016/j.jep.2004.12.020 10.2174/0929867053363351 10.1055/s-2007-971236 10.1078/0944-7113-00044 10.1016/0006-2952(91)90021-V 10.1107/S0108270193011357 10.1016/S0140-6736(78)90365-3 10.3109/13880209409083007 10.1076/phbi.35.4.227.13306 10.1016/S0041-0101(02)00128-9 10.1590/S0074-02761991000600041 10.1590/S0037-86822006000300006 10.1016/0378-8741(86)90043-7 10.1126/science.781840 10.1016/0031-9422(93)80026-O 10.1590/S0074-02762002000300017 10.1021/jo00893a023 10.1016/j.toxlet.2005.07.003 10.1007/978-3-642-72726-9_4 10.1016/j.jpba.2005.06.013 10.1126/science.3890182 10.1590/S0044-59672006000300006 10.1076/phbi.34.4.249.13234 10.1002/pca.2800020303 10.1016/j.chemosphere.2006.02.032 10.1590/S0100-40422001000200006 10.2307/3280287 |
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| Keywords | 12-acetylneosergeolide 1,12-diacetylisobrucein B isobrucein B antimalarial neosergeolide cytotoxicity larvicide |
| Language | English |
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| References | Aki H (ref1) 1991; 41 Milliken W (ref29) 1997 Pérez H (ref40) 1997; 35 Siqueira JM (ref48) 2001; 24 Meyer BN (ref28) 1982; 45 Muñoz-Castañeda JR (ref33) 2006; 160 (ref12) 2008 Labbe C (ref24) 1993; 34 Rieckmann KH (ref45) 1978; 1 Aparicio RM (ref5) 2005; 39 (ref55) 2005 Grinberg LN (ref19) 1997; 54 Mongelli E (ref30) 1996; 34 Pohlit AM (ref41) 2004; 34 Kupchan SM (ref23) 1975; 40 Polonsky J (ref43) 1984; 47 Finney DJ (ref17) 1971 Guo Z (ref20) 2005; 12 Zhang A (ref56) 1997; 61 (ref54) 2001 Parra AL (ref39) 2001; 8 Balandrin MF (ref8) 1985; 228 Polonsky J (ref42) 1973; 30 Lexis LA (ref26) 2006; 98 Okano M (ref38) 1995; 94 Kiran SR (ref22) 2006; 97 Munro MHG (ref34) 1987 Oberlies NH (ref37) 1998; 61 Amorim RCN (ref2) 2006; 2 Vastergaard LS (ref52) 2007; 77 Duke JA (ref15) 1994 Andrade-Neto VF (ref4) 2007; 102 van Agtmael MA (ref51) 1999; 20 Costa-Lotufo LV (ref14) 2002; 40 Cepleanu F (ref13) 1994; 32 Lambros C (ref25) 1979; 65 Sharma P (ref47) 2001; 74 Grenand P (ref18) 1987; 108 Bertani S (ref9) 2005; 98 Anderson JE (ref3) 1991; 2 Moretti C (ref31) 1982; 23 Boyer S (ref10) 2006; 65 Vigneron M (ref53) 2005; 98 Fatope MO (ref16) 1993; 31 Bader G (ref7) 1996 Trager W (ref50) 1976; 193 Nunomura RCS (ref36) 2006; 36 Sukamar K (ref49) 1991; 7 Ng TB (ref35) 1986; 18 Mosmann T (ref32) 1983; 65 Carvalho LH (ref11) 1991; 86 Quignard ELJ (ref44) 2003; 33 Gusmão DS (ref21) 2002; 97 Lima EP (ref27) 2006; 39 Schpector JZ (ref46) 1994; 50 Badaway AS (ref6) 1997; 32 Lexis, LA; Fassett, RG; Coombes, JS 2006; 98 Sharma, P; Sharma, JD 2001; 74 Lambros, C; Vanderberg, JP 1979; 65 Amorim, RCN; Pohlit, AM 2006; 2 Aki, H; Yamamoto, M 1991; 41 Duke, JA; Vasquez, R 1994 Kupchan, SM; Britton, RW; Lacadie, JA; Ziegler, MF; Sigel, CWJ 1975; 40 Grenand, P; Moretti, C; Jacquemin, H 1987; 108 Guo, Z; Vangapandu, S; Sindelar, RW; Walker, LA; Sindelar, RD 2005; 12 Gusmão, DS; Páscoa, V; Mathias, L; Vieira, IJC; Braz-Filho, R; Lemos, FJA 2002; 97 Muñoz-Castañeda, JR; Muntané, J; Muñoz, MC; Bujalance, I; Montilla, P; Tunez, I 2006; 160 Sukamar, K; Perich, MJ; Boobar, LR 1991; 7 Oberlies, NH; Rogers, LL; Martin, JM; McLaughlin, JL 1998; 61 Meyer, BN; Ferrigini, NR; Putnam, JE; Jacobsen, LB; Nichols, DE; McLaughlin, JE 1982; 45 2001 Nunomura, RCS; Silva, ECC; Oliveira, DF; Garcia, AM; Boeloni, JN; Nunomura, SM; Pohlit, AM 2006; 36 Carvalho, LH; Krettli, AU 1991; 86 Vastergaard, LS; Ringwald, P 2007; 77 Mosmann, T 1983; 65 Siqueira, JM; Ziminiani, MG; Resende, UM; Boaventura, MAD 2001; 24 Balandrin, MF 1985; 228 Lima, EP; Oliveira Filho, AM; Lima, JWO; Ramos Júnior, AN; Cavalcanti, LPG; Pontes, RJS 2006; 39 Ng, TB; Li, WW; Yeung, HW 1986; 18 Anderson, JE; Goetz, CM; Mc Laughlin, JL; Suffness, M 1991; 2 Milliken, W 1997 Trager, W; Jensen, JB 1976; 193 Bader, G; Plohmann, B; Hiller, K; Franz, G 1996 Cepleanu, F; Hamburger, MO; Sordat, B; Msonthi, JD; Gupta, MP; Saadou, M; Hostettmann, K 1994; 32 Pohlit, AM; Quignard, ELJ; Nunomura, SM; Tadei, WP; Hidalgo, AF; Pinto, ACS; Santos, EVM; Alecrim, AM; Ferraz, AB; Pedroso, ACS; Diniz, EV; Finney, EK; Gomes, EO; Don, LC; Queiroz, MMA; Henrique, MC; Santos, M; Lacerda Junior, OS; Pinto, PS; Silva, SG; Graça, YR 2004; 34 Parra, AL; Yhebra, RS; Sardiñas, IG; Buela, LI 2001; 8 Bertani, S; Bourdy, G; Landau, I; Robinson, JC; Esterre, P; Deharo, E 2005; 98 Finney, DJ 1971 Polonsky, J 1973; 30 Rieckmann, KH; Sax, LJ; Campbell, GH; Mrema, JE 1978; 1 2008 Badaway, AS; Kappe, T 1997; 32 2005 Zhang, A; Zhu, QY; Luk, YS; Ho, KY; Fung, KP; Chen, ZY 1997; 61 Vigneron, M; Deparis, X; Deharo, E; Bourdy, G 2005; 98 Schpector, JZ; Castellano, EE; Fho, ER; Vieira, IJC 1994; 50 Boyer, S; Sérandour, J; Lempérière, G; Raveton, M; Ravanel, P 2006; 65 Munro, MHG; Luibrand, RT; Blunt, JW; PJ, Scheuer 1987 Pérez, H; Díaz, F; Medina, JD 1997; 35 Polonsky, J; Bhatnagar, S; Moretti, C 1984; 47 Labbe, C; Castillo, M; Connoly, JD 1993; 34 Moretti, C; Polonsky, J; Vuilhorgne, M; Prange, T 1982; 23 Quignard, ELJ; Pohlit, AM; Nunomura, SM; Pinto, ACS; Santos, EVM; Morais, SKR; Alecrim, AM; Pedroso, ACS; Cyrino, BRB; Melo, CS; Finney, EK; Gomes, EO; Souza, KS; Oliveira, LCP; Don, LC; Silva, LFR; Queiroz, MMA; Henrique, MC; Santos, M; Pinto, PS; Silva, SG 2003; 33 Aparicio, RM; García-Celma, MJ; Vinardell, MP; Mitjans, M 2005; 39 Andrade-Neto, VF; Pohlit, AM; Pinto, ACS; Silva, ECC; Nogueira, KL; Melo, MRS; Henrique, MC; Amorim, RCN; Silva, LFR; Costa, MRF; Nunomura, RCS; Nunomura, SM; Alecrim, WD; Alecrim, MGC; Chaves, FCM; Vieira, PPR 2007; 102 Kiran, SR; Bhavani, K; Devi, PS; Rao, BRR; Reddy, KJ 2006; 97 Fatope, MO; Ibrahim, H; Takeda, Y 1993; 31 Mongelli, E; Martino, V; Coussio, J; Ciccia, G 1996; 34 Costa-Lotufo, LV; Cunha, GMA; Farias, PAM; Viana, GSB; Cunha, KMA; Pessoa, CO; Moraes, MO; Silveira, ER; Gramosa, NV; Rao, VSN 2002; 40 Okano, M; Fukamiya, N; Tagahara, K; Tokuda, H; Iwashima, A; Nishino, H; Lee, H 1995; 94 Grinberg, LN; Newmark, H; Kitrossky, N; Rahamim, E; Chevion, M; Rachmilewitz, EA 1997; 54 van Agtmael, MA; Egglle, TA; van Boxtel, CJ 1999; 20 |
| References_xml | – volume: 2 start-page: 10 year: 2006 ident: ref2 article-title: Picrolemma sprucei Hook. f: uso tradicional, princípios ativos e seus derivados semi-sintéticos, exploração comercial e econômica publication-title: Fitos – volume: 7 start-page: 210 issn: 8756-971X year: 1991 ident: ref49 article-title: Botanical derivatives in mosquito control: a review publication-title: J Am Mosq Control Assoc – volume: 77 start-page: 153 issn: 0002-9637 year: 2007 ident: ref52 article-title: Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2007.77.153 – volume: 47 start-page: 994 issn: 0163-3864 year: 1984 ident: ref43 article-title: 15-deacetyl-sergeolide, a potent antileukemic quassinoid from Picrolemma pseudocoffea publication-title: J Nat Prod doi: 10.1021/np50036a014 – volume: 98 start-page: 68 year: 2006 ident: ref26 article-title: ±-Tocopherol and ±-lipoic acid enhance the erythrocyte antioxidant defence in cyclosporine A-treated rats publication-title: Basic Clin Pharmacol Toxicol doi: 10.1111/j.1742-7843.2006.pto_222.x – volume: 97 start-page: 2481 year: 2006 ident: ref22 article-title: Composition and larvicidal activity of leaves and stem essential oils of Chloroxylon swietenia DC against Aedes aegypti and Anopheles stephensi publication-title: Bioresour Technol doi: 10.1016/j.biortech.2005.10.003 – volume: 34 start-page: 97 issn: 0100-1329 year: 2004 ident: ref41 article-title: Screening of plants found in Amazonas State, Brazil for activity against Aedes aegypti larvae publication-title: Acta Amazonica doi: 10.1590/S0044-59672004000100012 – volume: 61 start-page: 781 issn: 0163-3864 year: 1998 ident: ref37 article-title: Cytotoxic and insecticidal constituents of the unripe fruit of Persea Americana publication-title: J Nat Prod doi: 10.1021/np9800304 – volume: 20 start-page: 199 year: 1999 ident: ref51 article-title: Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication publication-title: Tips – year: 1994 ident: ref15 – year: 2001 ident: ref54 – volume: 61 start-page: 383 issn: 0024-3205 year: 1997 ident: ref56 article-title: Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells publication-title: Life Sci doi: 10.1016/S0024-3205(97)00395-0 – volume: 54 start-page: 973 issn: 0006-2952 year: 1997 ident: ref19 article-title: Protective effects of tea polyphenols against oxidative damage to red blood cells publication-title: Biochem Pharmacol doi: 10.1016/S0006-2952(97)00155-X – volume: 74 start-page: 239 year: 2001 ident: ref47 article-title: In vitro hemolysis of human erythrocytes by plant extracts with antiplasmodial activity publication-title: J Ethnophamacol doi: 10.1016/S0378-8741(00)00370-6 – volume: 33 start-page: 93 issn: 0100-1329 year: 2003 ident: ref44 article-title: Screening of plants found in Amazonas State for lethality towards brine shrimp publication-title: Acta Amazonica doi: 10.1590/1809-4392200331104 – volume: 102 start-page: 359 issn: 0074-0276 year: 2007 ident: ref4 article-title: vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants publication-title: Mem Inst Oswaldo Cruz doi: 10.1590/S0074-02762007000300016 – volume: 32 start-page: 815 issn: 0223-5234 year: 1997 ident: ref6 article-title: Potential antineoplastics: Synthesis and cytotoxicity of certain 4-chloro-3-(2-chloroethyl)-2-methylquinolines and related derivatives publication-title: Eur J Med Chem doi: 10.1016/S0223-5234(99)80067-1 – year: 1997 ident: ref29 – volume: 31 start-page: 250 year: 1993 ident: ref16 article-title: Screening of higher plant reputed as pesticides using the brine shrimp lethality assay publication-title: Int J Pharmacog doi: 10.3109/13880209309082949 – volume: 94 start-page: 139 issn: 0096-3917 year: 1995 ident: ref38 article-title: Inhibitory effects of quassinoids on Epstein-Barr virus activation publication-title: Cancer Lett doi: 10.1016/0304-3835(95)03839-O – volume: 98 start-page: 351 issn: 0378-8741 year: 2005 ident: ref53 article-title: Antimalarial remedies in French Guiana: a knowledge attitudes and practices study publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2005.01.049 – volume: 23 start-page: 647 issn: 0040-4039 year: 1982 ident: ref31 article-title: Isolation and structure of sergeolide, a potent cytotoxic quassinoid from Picrolemma pseudocoffea publication-title: Tetrahedron Lett doi: 10.1016/S0040-4039(00)86912-9 – volume: 65 start-page: 55 issn: 0022-1759 year: 1983 ident: ref32 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferative and cytotoxicity assays publication-title: J Immunol Methods doi: 10.1016/0022-1759(83)90303-4 – volume: 98 start-page: 45 issn: 0378-8741 year: 2005 ident: ref9 article-title: Evaluation of French Guiana traditional antimalarial remedies publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2004.12.020 – year: 2008 ident: ref12 – volume: 12 start-page: 173 issn: 0929-8673 year: 2005 ident: ref20 article-title: Biologically active quassinoids and their chemistry: potentianl leads for drug design publication-title: Curr Med Chem doi: 10.2174/0929867053363351 – volume: 45 start-page: 34 issn: 0032-0943 year: 1982 ident: ref28 article-title: Brine shrimp: a convenient general bioassay for active plant constituents publication-title: Planta Med doi: 10.1055/s-2007-971236 – volume: 8 start-page: 395 issn: 0944-7113 year: 2001 ident: ref39 article-title: Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50) in mice, to determine oral acute toxicity of plant extracts. publication-title: Phytomedicine doi: 10.1078/0944-7113-00044 – volume: 41 start-page: 133 issn: 0006-2952 year: 1991 ident: ref1 article-title: Drug binding to human erythrocytes in the process of ionic drug-induced hemolysis: Flow microcalorimetric approaches publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(91)90021-V – volume: 50 start-page: 794 issn: 0108-2701 year: 1994 ident: ref46 article-title: A new quassinoid isolated from Picrolemma pseudocoffea publication-title: Acta Crystallogr C doi: 10.1107/S0108270193011357 – year: 1971 ident: ref17 – volume: 1 start-page: 22 issn: 0099-5355 year: 1978 ident: ref45 article-title: Drug sensitivity of Plasmodium falciparum: An in vitro microtechinique publication-title: Lancet doi: 10.1016/S0140-6736(78)90365-3 – volume: 32 start-page: 294 year: 1994 ident: ref13 article-title: Screening of tropical medicinal plants for molluscicidal, larvicidal, fungicidal and cytotoxic activities and brine shrimp toxicity publication-title: Int J Pharmacog doi: 10.3109/13880209409083007 – volume: 35 start-page: 227 year: 1997 ident: ref40 article-title: Chemical investigation and in vitro antimalarial activity of Tabebuia ochracea ssp. neochrysantha publication-title: Int J Pharmacog doi: 10.1076/phbi.35.4.227.13306 – volume: 40 start-page: 1231 issn: 0041-0101 year: 2002 ident: ref14 article-title: The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorfii oleo-resin publication-title: Toxicon doi: 10.1016/S0041-0101(02)00128-9 – start-page: 414 issn: 0031-7144 year: 1996 ident: ref7 article-title: Cytotoxicity of tri-terpenoid saponins: Part 1: Activities against tumor cells in vitro and hemolytical index publication-title: Pharmazie – volume: 30 start-page: 101 issn: 0071-7886 year: 1973 ident: ref42 article-title: Quassinoid bitter principles publication-title: Fortschr Chem Org Naturst – volume: 86 start-page: 181 issn: 0074-0276 year: 1991 ident: ref11 article-title: Antimalarial chemotherapy with natural products and chemically defined molecules publication-title: Mem Inst Oswaldo Cruz doi: 10.1590/S0074-02761991000600041 – volume: 39 start-page: 259 issn: 0037-8682 year: 2006 ident: ref27 article-title: Resistência do Aedes aegypti ao temefós em municípios do estado do Ceará publication-title: Rev Soc Bras Med Trop doi: 10.1590/S0037-86822006000300006 – volume: 18 start-page: 55 issn: 0378-8741 year: 1986 ident: ref35 article-title: A steryl glycoside fraction with hemolytic activity from tubers of Momordica cochinchinensis publication-title: J Ethnopharmacol doi: 10.1016/0378-8741(86)90043-7 – year: 2005 ident: ref55 – volume: 193 start-page: 673 issn: 0036-8075 year: 1976 ident: ref50 article-title: Human malaria parasites in continuous culture publication-title: Science doi: 10.1126/science.781840 – volume: 34 start-page: 441 issn: 0031-9422 year: 1993 ident: ref24 article-title: Mono ad sesquiterpenoids from Satureja gilliesii publication-title: Phytochemistry doi: 10.1016/0031-9422(93)80026-O – volume: 97 start-page: 371 issn: 0074-0276 year: 2002 ident: ref21 article-title: Derris (Lonchocarpus) urucu (Leguminosae) extract modifies the peritrophic matrix structure of Aedes aegypti (Diptera: Culicidae) publication-title: Mem Inst Oswaldo Cruz doi: 10.1590/S0074-02762002000300017 – volume: 40 issn: 0022-3263 year: 1975 ident: ref23 article-title: The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica publication-title: J Org Chem doi: 10.1021/jo00893a023 – volume: 160 start-page: 196 issn: 0378-4274 year: 2006 ident: ref33 article-title: Estradiol and catecholestrogens protect against adriamycininduced oxidative stress in erythrocytes of ovariectomized rats publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2005.07.003 – start-page: 93 volume-title: The search for antiviral and anticancer compounds from marine organisms year: 1987 ident: ref34 doi: 10.1007/978-3-642-72726-9_4 – volume: 39 start-page: 1063 issn: 0731-7085 year: 2005 ident: ref5 article-title: In vitro studies of the hemolytic activity of microemulsions in human erythrocytes publication-title: J Pharm Biomed Anal doi: 10.1016/j.jpba.2005.06.013 – volume: 228 start-page: 1154 issn: 0036-8075 year: 1985 ident: ref8 article-title: Natural plant chemicals: sources of industrial and medicinal materials publication-title: Science doi: 10.1126/science.3890182 – volume: 36 start-page: 327 issn: 0100-1329 year: 2006 ident: ref36 article-title: vitro studies of the anthel-mintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae) publication-title: Acta Amazonica doi: 10.1590/S0044-59672006000300006 – volume: 34 start-page: 249 year: 1996 ident: ref30 article-title: Screening of Argentine medicinal plants using the brine shrimp microwell citotoxicity assay publication-title: Int J Pharmacog doi: 10.1076/phbi.34.4.249.13234 – volume: 2 start-page: 107 year: 1991 ident: ref3 article-title: A blind comparison of simple bench-top bioassay and human tumour cell cytotoxicities as antitumor prescreens publication-title: Phytochem Anal doi: 10.1002/pca.2800020303 – volume: 65 start-page: 721 issn: 0045-6535 year: 2006 ident: ref10 article-title: Do herbicide treatments reduce the sensitivity of mosquito larvae to insecticides? publication-title: Chemosphere doi: 10.1016/j.chemosphere.2006.02.032 – volume: 108 year: 1987 ident: ref18 – volume: 24 start-page: 185 year: 2001 ident: ref48 article-title: Estudo fitoquímico das cascas do caule de Duguetia glabriúscula - Annonaceae, biomonitorado pelo ensaio de toxicidade frente à Artemia salina Leach publication-title: Quim Nova doi: 10.1590/S0100-40422001000200006 – volume: 65 start-page: 418 issn: 0022-3395 year: 1979 ident: ref25 article-title: Syncronization of Plasmodium falciparum erythrocytic stages in culture publication-title: J Parasitol doi: 10.2307/3280287 – start-page: 93 year: 1987 end-page: 176 publication-title: Bioorganic Mar Chem – volume: 97 start-page: 2481 year: 2006 end-page: 2484 article-title: Composition and larvicidal activity of leaves and stem essential oils of Chloroxylon swietenia DC against Aedes aegypti and Anopheles stephensi publication-title: Bioresour Technol – volume: 39 start-page: 1063 year: 2005 end-page: 1067 article-title: In vitro studies of the hemolytic activity of microemulsions in human erythrocytes publication-title: J Pharm Biomed Anal – start-page: 414 year: 1996 end-page: 417 article-title: Cytotoxicity of tri-terpenoid saponins: Part 1: Activities against tumor cells in vitro and hemolytical index publication-title: Pharmazie – volume: 86 start-page: 181 year: 1991 end-page: 184 article-title: Antimalarial chemotherapy with natural products and chemically defined molecules publication-title: Mem Inst Oswaldo Cruz – volume: 45 start-page: 34 year: 1982 end-page: 37 article-title: Brine shrimp: a convenient general bioassay for active plant constituents publication-title: Planta Med – volume: 32 start-page: 815 year: 1997 end-page: 822 article-title: Potential antineoplastics: Synthesis and cytotoxicity of certain 4-chloro-3-(2-chloroethyl)-2-methylquinolines and related derivatives publication-title: Eur J Med Chem – volume: 40 start-page: 1231 year: 2002 end-page: 1234 article-title: The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorfii oleo-resin publication-title: Toxicon – year: 1971 publication-title: Probit analysis – year: 2005 publication-title: Roll back malaria world malaria report 2005 – volume: 61 start-page: 781 year: 1998 end-page: 785 article-title: Cytotoxic and insecticidal constituents of the unripe fruit of Persea Americana publication-title: J Nat Prod – volume: 23 start-page: 647 year: 1982 end-page: 650 article-title: Isolation and structure of sergeolide, a potent cytotoxic quassinoid from Picrolemma pseudocoffea publication-title: Tetrahedron Lett – volume: 77 start-page: 153 year: 2007 end-page: 159 article-title: Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies publication-title: Am J Trop Med Hyg – volume: 36 start-page: 327 year: 2006 end-page: 330 article-title: vitro studies of the anthel-mintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae) publication-title: Acta Amazonica – volume: 228 start-page: 1154 year: 1985 end-page: 1160 article-title: Natural plant chemicals: sources of industrial and medicinal materials publication-title: Science – volume: 97 start-page: 371 year: 2002 end-page: 375 article-title: Derris (Lonchocarpus) urucu (Leguminosae) extract modifies the peritrophic matrix structure of Aedes aegypti (Diptera: Culicidae) publication-title: Mem Inst Oswaldo Cruz – volume: 47 start-page: 994 year: 1984 end-page: 996 article-title: 15-deacetyl-sergeolide, a potent antileukemic quassinoid from Picrolemma pseudocoffea publication-title: J Nat Prod – volume: 12 start-page: 173 year: 2005 end-page: 190 article-title: Biologically active quassinoids and their chemistry: potentianl leads for drug design publication-title: Curr Med Chem – volume: 8 start-page: 395 year: 2001 end-page: 400 article-title: Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50) in mice, to determine oral acute toxicity of plant extracts. publication-title: Phytomedicine – volume: 34 start-page: 97 year: 2004 end-page: 105 article-title: Screening of plants found in Amazonas State, Brazil for activity against Aedes aegypti larvae publication-title: Acta Amazonica – volume: 34 start-page: 441 year: 1993 end-page: 444 article-title: Mono ad sesquiterpenoids from Satureja gilliesii publication-title: Phytochemistry – volume: 2 start-page: 107 year: 1991 end-page: 111 article-title: A blind comparison of simple bench-top bioassay and human tumour cell cytotoxicities as antitumor prescreens publication-title: Phytochem Anal – volume: 108 year: 1987 publication-title: Pharmacopées traditionnelles en Guyane, Guyane Française. – volume: 34 start-page: 249 year: 1996 end-page: 254 article-title: Screening of Argentine medicinal plants using the brine shrimp microwell citotoxicity assay publication-title: Int J Pharmacog – volume: 50 start-page: 794 year: 1994 end-page: 797 article-title: A new quassinoid isolated from Picrolemma pseudocoffea publication-title: Acta Crystallogr C – volume: 65 start-page: 721 year: 2006 end-page: 724 article-title: Do herbicide treatments reduce the sensitivity of mosquito larvae to insecticides? publication-title: Chemosphere – volume: 40 year: 1975 article-title: The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica publication-title: J Org Chem – year: 1997 publication-title: Plants for malaria. Plants for fever: medicinal species in Latin America - a bibliographic survey – volume: 98 start-page: 45 year: 2005 end-page: 54 article-title: Evaluation of French Guiana traditional antimalarial remedies publication-title: J Ethnopharmacol – volume: 41 start-page: 133 year: 1991 end-page: 138 article-title: Drug binding to human erythrocytes in the process of ionic drug-induced hemolysis: Flow microcalorimetric approaches publication-title: Biochem Pharmacol – volume: 31 start-page: 250 year: 1993 end-page: 254 article-title: Screening of higher plant reputed as pesticides using the brine shrimp lethality assay publication-title: Int J Pharmacog – volume: 54 start-page: 973 year: 1997 end-page: 978 article-title: Protective effects of tea polyphenols against oxidative damage to red blood cells publication-title: Biochem Pharmacol – volume: 74 start-page: 239 year: 2001 end-page: 243 article-title: In vitro hemolysis of human erythrocytes by plant extracts with antiplasmodial activity publication-title: J Ethnophamacol – volume: 33 start-page: 93 year: 2003 end-page: 104 article-title: Screening of plants found in Amazonas State for lethality towards brine shrimp publication-title: Acta Amazonica – volume: 24 start-page: 185 year: 2001 end-page: 187 article-title: Estudo fitoquímico das cascas do caule de Duguetia glabriúscula - Annonaceae, biomonitorado pelo ensaio de toxicidade frente à Artemia salina Leach publication-title: Quim Nova – volume: 30 start-page: 101 year: 1973 end-page: 150 article-title: Quassinoid bitter principles publication-title: Fortschr Chem Org Naturst – year: 1994 publication-title: Amazonian ethnobotanical dictionary – volume: 65 start-page: 55 year: 1983 end-page: 63 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferative and cytotoxicity assays publication-title: J Immunol Methods – volume: 2 start-page: 10 year: 2006 end-page: 14 article-title: Picrolemma sprucei Hook. f: uso tradicional, princípios ativos e seus derivados semi-sintéticos, exploração comercial e econômica publication-title: Fitos – volume: 98 start-page: 68 year: 2006 end-page: 73 article-title: ±-Tocopherol and ±-lipoic acid enhance the erythrocyte antioxidant defence in cyclosporine A-treated rats publication-title: Basic Clin Pharmacol Toxicol – volume: 102 start-page: 359 year: 2007 end-page: 365 article-title: vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants publication-title: Mem Inst Oswaldo Cruz – volume: 61 start-page: 383 year: 1997 end-page: 394 article-title: Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells publication-title: Life Sci – volume: 7 start-page: 210 year: 1991 end-page: 237 article-title: Botanical derivatives in mosquito control: a review publication-title: J Am Mosq Control Assoc – volume: 35 start-page: 227 year: 1997 end-page: 231 article-title: Chemical investigation and in vitro antimalarial activity of Tabebuia ochracea ssp. neochrysantha publication-title: Int J Pharmacog – year: 2008 publication-title: The impact of malaria, a leading cause of death worldwide – volume: 1 start-page: 22 year: 1978 end-page: 23 article-title: Drug sensitivity of Plasmodium falciparum: An in vitro microtechinique publication-title: Lancet – volume: 160 start-page: 196 year: 2006 end-page: 203 article-title: Estradiol and catecholestrogens protect against adriamycininduced oxidative stress in erythrocytes of ovariectomized rats publication-title: Toxicol Lett – volume: 20 start-page: 199 year: 1999 end-page: 205 article-title: Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication publication-title: Tips – volume: 94 start-page: 139 year: 1995 end-page: 146 article-title: Inhibitory effects of quassinoids on Epstein-Barr virus activation publication-title: Cancer Lett – year: 2001 publication-title: In vitro micro-test (Mark III) for the assessment of the response of Plasmodium falciparum to chloroquine, mefloquine, quinine, amodiaquine, sulfadoxine/pyrimetamine and artemisinin. – volume: 193 start-page: 673 year: 1976 end-page: 675 article-title: Human malaria parasites in continuous culture publication-title: Science – volume: 39 start-page: 259 year: 2006 end-page: 263 article-title: Resistência do Aedes aegypti ao temefós em municípios do estado do Ceará publication-title: Rev Soc Bras Med Trop – volume: 32 start-page: 294 year: 1994 end-page: 307 article-title: Screening of tropical medicinal plants for molluscicidal, larvicidal, fungicidal and cytotoxic activities and brine shrimp toxicity publication-title: Int J Pharmacog – volume: 18 start-page: 55 year: 1986 end-page: 61 article-title: A steryl glycoside fraction with hemolytic activity from tubers of Momordica cochinchinensis publication-title: J Ethnopharmacol – volume: 65 start-page: 418 year: 1979 end-page: 420 article-title: Syncronization of Plasmodium falciparum erythrocytic stages in culture publication-title: J Parasitol – volume: 98 start-page: 351 year: 2005 end-page: 360 article-title: Antimalarial remedies in French Guiana: a knowledge attitudes and practices study publication-title: J Ethnopharmacol |
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| Snippet | In the present study, in vitro techniques were used to investigate a
range of biological activities of known natural quassinoids isobrucein
B (1) and... In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and... |
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| SubjectTerms | 1,12-diacetylisobrucein B 12-acetylneosergeolide Aedes - drug effects Aedes aegypti Animals antimalarial Artemia - drug effects Artemia franciscana cytotoxicity Erythrocytes - drug effects Hemolysis - drug effects HL-60 Cells - drug effects Humans isobrucein B larvicide Lethal Dose 50 Mice neosergeolide neosergeolide - isobrucein B - 12-acetylneosergeolide - 1,12-diacetylisobrucein B - cytotoxicity - antimalarial - larvicide PARASITOLOGY Plants, Medicinal Plasmodium falciparum Plasmodium falciparum - drug effects Quassins - isolation & purification Quassins - pharmacology Simaroubaceae Simaroubaceae - chemistry TROPICAL MEDICINE |
| Title | Biological activity of neosergeolide and isobrucein B (and two semi-synthetic derivatives) isolated from the Amazonian medicinal plant Picrolemma sprucei (Simaroubaceae) |
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