Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis
Objective: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable y...
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| Vydané v: | Annals of the rheumatic diseases Ročník 66; číslo 1; s. 121 - 123 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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London
BMJ Publishing Group Ltd and European League Against Rheumatism
01.01.2007
BMJ Elsevier Limited BMJ Group |
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| ISSN: | 0003-4967, 1468-2060, 1468-2060 |
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| Abstract | Objective: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis. Methods: A nested case–control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay. Results: When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls. Conclusion: Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis. |
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| AbstractList | OBJECTIVE: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis. METHODS: A nested case-control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay. RESULTS: When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls. CONCLUSION: Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis. To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis.OBJECTIVETo analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis.A nested case-control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay.METHODSA nested case-control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay.When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls.RESULTSWhen the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls.Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis.CONCLUSIONLevels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis. Objective: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis. Methods: A nested case–control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay. Results: When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls. Conclusion: Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis. To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis. A nested case-control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay. When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls. Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis. |
| Author | Tarkowski, A Boman, K Rantapää-Dahlqvist, S Hallmans, G |
| AuthorAffiliation | S Rantapää‐Dahlqvist , G Hallmans , Departments of Rheumatology and Nutritional Research, Umeå University, Umeå, Sweden A Tarkowski , Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden K Boman , Department of Medicine, Skellefteå Hospital, Skellefteå, Sweden |
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| Author_xml | – sequence: 1 givenname: S surname: Rantapää-Dahlqvist fullname: Rantapää-Dahlqvist, S organization: Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden – sequence: 2 givenname: K surname: Boman fullname: Boman, K organization: Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden – sequence: 3 givenname: A surname: Tarkowski fullname: Tarkowski, A organization: Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden – sequence: 4 givenname: G surname: Hallmans fullname: Hallmans, G organization: Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden |
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| Keywords | Human Immunopathology Rheumatoid factor Chronic Immunoglobulins Monocyte Antibody Rheumatoid arthritis Diseases of the osteoarticular system Autoimmune disease Inflammatory joint disease Citrulline Rheumatoid/blood Arthritis |
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| Notes | Correspondence to:
S Rantapää-Dahlqvist
Department of Rheumatology, University Hospital, SE-901 85 Umeå, Sweden; Solbritt.Rantapaa.Dahlqvist@medicin.umu.se PMID:16740681 istex:ED5BD3DC40A75C285F5D86101791A2478E49864D local:0660121 href:annrheumdis-66-121.pdf ark:/67375/NVC-P44MWDV0-Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| References_xml | – volume: 50 start-page: 2423 year: 2004 ident: 10.1136/ard.2006.057331_bib9 article-title: Increased levels of C-reactive protein in serum from blood donors before the onset of rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.20431 – volume: 65 start-page: 453 year: 2006 ident: 10.1136/ard.2006.057331_bib16 article-title: Antibodies against cyclic citrullinated peptide before disease onset predict radiological outcome of rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/ard.2005.041376 – volume: 7 start-page: 230 year: 2005 ident: 10.1136/ard.2006.057331_bib17 article-title: Does a positive anti-CCP test identify a distinct arthritis entity? publication-title: Arthritis Res Ther doi: 10.1186/ar1836 – volume: 108 start-page: 175 year: 1997 ident: 10.1136/ard.2006.057331_bib6 article-title: Coordinate expression of group II phospholipase A2 and the acute-phase proteins haptoglobin (HP) and alpha1-anti-chymotrypsin (ACH) by HepG2 cells publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1997.d01-990.x – volume: 26 start-page: 1393 year: 1995 ident: 10.1136/ard.2006.057331_bib13 article-title: Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke publication-title: Stroke doi: 10.1161/01.STR.26.8.1393 – volume: 27 start-page: 1136 year: 2000 ident: 10.1136/ard.2006.057331_bib7 article-title: Serum C-reactive protein does not predict rheumatoid arthritis publication-title: J Rheumatol – volume: 81 start-page: 424 year: 2002 ident: 10.1136/ard.2006.057331_bib12 article-title: C-reactive protein: a serological marker for preterm delivery? publication-title: Acta Obstet Gynecol Scand doi: 10.1034/j.1600-0412.2002.810509.x – volume: 36 start-page: 26 year: 1993 ident: 10.1136/ard.2006.057331_bib15 article-title: Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor alpha and interferon-gamma publication-title: Arthritis Rheum doi: 10.1002/art.1780360106 – volume: 6 start-page: R303 year: 2004 ident: 10.1136/ard.2006.057331_bib2 article-title: A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis publication-title: Arthritis Res Ther doi: 10.1186/ar1187 – volume: 12 start-page: 143 year: 1991 ident: 10.1136/ard.2006.057331_bib5 article-title: Phospholipase A2: a mediator between proximal and distal effectors of inflammation publication-title: Immunol Today – volume: 48 start-page: 2741 year: 2003 ident: 10.1136/ard.2006.057331_bib1 article-title: Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.11223 – volume: 8 start-page: R19 year: 2006 ident: 10.1136/ard.2006.057331_bib3 article-title: PTPN22 polymorphism and anti-CCP antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease publication-title: Arthritis Res Ther doi: 10.1186/ar1868 – volume: 90 start-page: 488 year: 1992 ident: 10.1136/ard.2006.057331_bib4 article-title: Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid publication-title: J Clin Invest doi: 10.1172/JCI115885 – volume: 31 start-page: 315 year: 1988 ident: 10.1136/ard.2006.057331_bib11 article-title: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.1780310302 – volume: 65 start-page: 535 year: 2006 ident: 10.1136/ard.2006.057331_bib10 article-title: Simultaneous development of acute phase response and autoantibodies in preclinical rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/ard.2005.040659 – volume: 28 start-page: 2359 year: 2001 ident: 10.1136/ard.2006.057331_bib8 article-title: Do elevated levels of serum C-reactive protein predict rheumatoid arthritis in men: correlations with pre-RA status and baseline positive rheumatoid factor publication-title: J Rheumatol – volume: 90 start-page: 772 year: 1992 ident: 10.1136/ard.2006.057331_bib14 article-title: Free in PMC enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis publication-title: J Clin Invest doi: 10.1172/JCI115950 |
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| Snippet | Objective: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of... To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid... OBJECTIVE: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of... |
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| SubjectTerms | Adult Aged Arthritis Arthritis, Rheumatoid - blood Autoantibodies - blood Biological and medical sciences Biological Markers/blood Biomarkers - blood Blood Donors C reactive protein C-Reactive Protein - analysis Case-Control Studies CCP Chemokine CCL2 - blood Chi-Square Distribution Citrulline - immunology Concise Report CRP cyclic citrullinated peptide Disease Progression Diseases of the osteoarticular system Female high-sensitivity C reactive protein hsCRP Humans IgM-RF Immunoglobulin M - blood immunoglobulin M-rheumatoid factor Immunoglobulins Inflammatory joint diseases Male MCP Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Middle Aged monocyte chemoattractant protein Rheumatism Rheumatoid arthritis Rheumatoid Factor - blood Rheumatoid/blood secretory phospholipase Severity of Illness Index sPL Time Factors Up-Regulation |
| Title | Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis |
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