Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis
BackgroundConventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission)...
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| Vydané v: | Thorax Ročník 74; číslo 5; s. 439 - 446 |
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| Hlavní autori: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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England
BMJ Publishing Group Ltd and British Thoracic Society
01.05.2019
BMJ Publishing Group LTD BMJ Publishing Group |
| Edícia: | Original article |
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| ISSN: | 0040-6376, 1468-3296, 1468-3296 |
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| Abstract | BackgroundConventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission) is of increasing clinical importance.ObjectiveTo assess associations between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes in patients with stable COPD.MethodsWe systematically searched electronic databases (August 2018) and identified 61 studies, which were synthesised, including meta-analyses to estimate pooled HRs, following Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.ResultsShorter 6MWD and elevated heart rate, fibrinogen, CRP and WCC were associated with higher risk of mortality. Pooled HRs were 0.80 (95% CI 0.73 to 0.89) per 50 m longer 6MWD, 1.10 (95% CI 1.02 to 1.18) per 10 bpm higher heart rate, 3.13 (95% CI 2.14 to 4.57) per twofold increase in fibrinogen, 1.17 (95% CI 1.06 to 1.28) per twofold increase in CRP and 2.07 (95% CI 1.29 to 3.31) per twofold increase in WCC. Shorter 6MWD and elevated fibrinogen and CRP were associated with exacerbation, and shorter 6MWD, higher heart rate, CRP and IL-6 were associated with hospitalisation. Few studies examined associations with musculoskeletal measures.ConclusionFindings suggest 6MWD, heart rate, CRP, fibrinogen and WCC are associated with clinical outcomes in patients with stable COPD. Use of musculoskeletal measures to assess outcomes in patients with COPD requires further investigation.Trial registration numberCRD42016052075. |
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| AbstractList | BackgroundConventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission) is of increasing clinical importance.ObjectiveTo assess associations between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes in patients with stable COPD.MethodsWe systematically searched electronic databases (August 2018) and identified 61 studies, which were synthesised, including meta-analyses to estimate pooled HRs, following Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.ResultsShorter 6MWD and elevated heart rate, fibrinogen, CRP and WCC were associated with higher risk of mortality. Pooled HRs were 0.80 (95% CI 0.73 to 0.89) per 50 m longer 6MWD, 1.10 (95% CI 1.02 to 1.18) per 10 bpm higher heart rate, 3.13 (95% CI 2.14 to 4.57) per twofold increase in fibrinogen, 1.17 (95% CI 1.06 to 1.28) per twofold increase in CRP and 2.07 (95% CI 1.29 to 3.31) per twofold increase in WCC. Shorter 6MWD and elevated fibrinogen and CRP were associated with exacerbation, and shorter 6MWD, higher heart rate, CRP and IL-6 were associated with hospitalisation. Few studies examined associations with musculoskeletal measures.ConclusionFindings suggest 6MWD, heart rate, CRP, fibrinogen and WCC are associated with clinical outcomes in patients with stable COPD. Use of musculoskeletal measures to assess outcomes in patients with COPD requires further investigation.Trial registration numberCRD42016052075. Conventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission) is of increasing clinical importance. To assess associations between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes in patients with stable COPD. We systematically searched electronic databases (August 2018) and identified 61 studies, which were synthesised, including meta-analyses to estimate pooled HRs, following Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Shorter 6MWD and elevated heart rate, fibrinogen, CRP and WCC were associated with higher risk of mortality. Pooled HRs were 0.80 (95% CI 0.73 to 0.89) per 50 m longer 6MWD, 1.10 (95% CI 1.02 to 1.18) per 10 bpm higher heart rate, 3.13 (95% CI 2.14 to 4.57) per twofold increase in fibrinogen, 1.17 (95% CI 1.06 to 1.28) per twofold increase in CRP and 2.07 (95% CI 1.29 to 3.31) per twofold increase in WCC. Shorter 6MWD and elevated fibrinogen and CRP were associated with exacerbation, and shorter 6MWD, higher heart rate, CRP and IL-6 were associated with hospitalisation. Few studies examined associations with musculoskeletal measures. Findings suggest 6MWD, heart rate, CRP, fibrinogen and WCC are associated with clinical outcomes in patients with stable COPD. Use of musculoskeletal measures to assess outcomes in patients with COPD requires further investigation. CRD42016052075. Conventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission) is of increasing clinical importance.BACKGROUNDConventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission) is of increasing clinical importance.To assess associations between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes in patients with stable COPD.OBJECTIVETo assess associations between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes in patients with stable COPD.We systematically searched electronic databases (August 2018) and identified 61 studies, which were synthesised, including meta-analyses to estimate pooled HRs, following Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.METHODSWe systematically searched electronic databases (August 2018) and identified 61 studies, which were synthesised, including meta-analyses to estimate pooled HRs, following Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Shorter 6MWD and elevated heart rate, fibrinogen, CRP and WCC were associated with higher risk of mortality. Pooled HRs were 0.80 (95% CI 0.73 to 0.89) per 50 m longer 6MWD, 1.10 (95% CI 1.02 to 1.18) per 10 bpm higher heart rate, 3.13 (95% CI 2.14 to 4.57) per twofold increase in fibrinogen, 1.17 (95% CI 1.06 to 1.28) per twofold increase in CRP and 2.07 (95% CI 1.29 to 3.31) per twofold increase in WCC. Shorter 6MWD and elevated fibrinogen and CRP were associated with exacerbation, and shorter 6MWD, higher heart rate, CRP and IL-6 were associated with hospitalisation. Few studies examined associations with musculoskeletal measures.RESULTSShorter 6MWD and elevated heart rate, fibrinogen, CRP and WCC were associated with higher risk of mortality. Pooled HRs were 0.80 (95% CI 0.73 to 0.89) per 50 m longer 6MWD, 1.10 (95% CI 1.02 to 1.18) per 10 bpm higher heart rate, 3.13 (95% CI 2.14 to 4.57) per twofold increase in fibrinogen, 1.17 (95% CI 1.06 to 1.28) per twofold increase in CRP and 2.07 (95% CI 1.29 to 3.31) per twofold increase in WCC. Shorter 6MWD and elevated fibrinogen and CRP were associated with exacerbation, and shorter 6MWD, higher heart rate, CRP and IL-6 were associated with hospitalisation. Few studies examined associations with musculoskeletal measures.Findings suggest 6MWD, heart rate, CRP, fibrinogen and WCC are associated with clinical outcomes in patients with stable COPD. Use of musculoskeletal measures to assess outcomes in patients with COPD requires further investigation.CONCLUSIONFindings suggest 6MWD, heart rate, CRP, fibrinogen and WCC are associated with clinical outcomes in patients with stable COPD. Use of musculoskeletal measures to assess outcomes in patients with COPD requires further investigation.CRD42016052075.TRIAL REGISTRATION NUMBERCRD42016052075. |
| Author | Masconi, Katya L Fermont, Jilles M Jensen, Magnus T Watz, Henrik Schuetz, Philipp Ferrari, Renata Di Lorenzo, Valéria A P Marott, Jacob M Waschki, Benjamin Wood, Angela M Müllerova, Hana Wilkinson, Ian B Polkey, Michael I |
| AuthorAffiliation | 10 Respiratory Muscle Laboratory, Royal Brompton Hospital , London , UK 7 Internal Medicine and Emergency Medicine, Kantonsspital Aarau , Univertsity of Basel , Aarau , Switzerland 3 Department of Cardiology , Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark 8 LungenClinic Grosshansorf, Airway Research Center North , German Center for Lung Research , Grosshansdorf , Germany 4 Copenhagen City Heart Study , Frederiksberg Hospital , Copenhagen , Denmark 2 Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care , University of Cambridge , Cambridge , UK 9 Worldwide Epidemiology, GlaxoSmithKline R&D , Uxbridge , UK 5 Division of Pulmonology, Department of Internal Medicine , Botucatu Medical School, Univ Estadual Paulista, UNESP , Botucatu , Brazil 6 Department of Physiotherapy , Federal University of Sao Carlos (UFSCar) , São Carlos/São Paulo , Brazil 1 Department of Medicine, Experimental Medicine and Immunotherapeutics , University of Cambridge , Cambrid |
| AuthorAffiliation_xml | – name: 8 LungenClinic Grosshansorf, Airway Research Center North , German Center for Lung Research , Grosshansdorf , Germany – name: 9 Worldwide Epidemiology, GlaxoSmithKline R&D , Uxbridge , UK – name: 4 Copenhagen City Heart Study , Frederiksberg Hospital , Copenhagen , Denmark – name: 6 Department of Physiotherapy , Federal University of Sao Carlos (UFSCar) , São Carlos/São Paulo , Brazil – name: 2 Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care , University of Cambridge , Cambridge , UK – name: 5 Division of Pulmonology, Department of Internal Medicine , Botucatu Medical School, Univ Estadual Paulista, UNESP , Botucatu , Brazil – name: 10 Respiratory Muscle Laboratory, Royal Brompton Hospital , London , UK – name: 1 Department of Medicine, Experimental Medicine and Immunotherapeutics , University of Cambridge , Cambridge , UK – name: 7 Internal Medicine and Emergency Medicine, Kantonsspital Aarau , Univertsity of Basel , Aarau , Switzerland – name: 3 Department of Cardiology , Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark |
| Author_xml | – sequence: 1 givenname: Jilles M surname: Fermont fullname: Fermont, Jilles M organization: Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK – sequence: 2 givenname: Katya L surname: Masconi fullname: Masconi, Katya L organization: Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK – sequence: 3 givenname: Magnus T surname: Jensen fullname: Jensen, Magnus T organization: Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark – sequence: 4 givenname: Renata surname: Ferrari fullname: Ferrari, Renata organization: Division of Pulmonology, Department of Internal Medicine, Botucatu Medical School, Univ Estadual Paulista, UNESP, Botucatu, Brazil – sequence: 5 givenname: Valéria A P surname: Di Lorenzo fullname: Di Lorenzo, Valéria A P organization: Department of Physiotherapy, Federal University of Sao Carlos (UFSCar), São Carlos/São Paulo, Brazil – sequence: 6 givenname: Jacob M surname: Marott fullname: Marott, Jacob M organization: Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark – sequence: 7 givenname: Philipp surname: Schuetz fullname: Schuetz, Philipp organization: Internal Medicine and Emergency Medicine, Kantonsspital Aarau, Univertsity of Basel, Aarau, Switzerland – sequence: 8 givenname: Henrik surname: Watz fullname: Watz, Henrik organization: LungenClinic Grosshansorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany – sequence: 9 givenname: Benjamin orcidid: 0000-0002-1070-3661 surname: Waschki fullname: Waschki, Benjamin organization: LungenClinic Grosshansorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany – sequence: 10 givenname: Hana surname: Müllerova fullname: Müllerova, Hana organization: Worldwide Epidemiology, GlaxoSmithKline R&D, Uxbridge, UK – sequence: 11 givenname: Michael I surname: Polkey fullname: Polkey, Michael I organization: Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK – sequence: 12 givenname: Ian B surname: Wilkinson fullname: Wilkinson, Ian B organization: Department of Medicine, Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK – sequence: 13 givenname: Angela M surname: Wood fullname: Wood, Angela M organization: Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30617161$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/2046-4053-4-1 10.1161/HYPERTENSIONAHA.117.10151 10.1097/PSY.0000000000000260 10.1016/j.rmed.2013.05.001 10.1007/s00408-009-9135-9 10.1590/S1413-35552012005000146 10.1186/1465-9921-14-24 10.2147/COPD.S76475 10.1183/09031936.00104507 10.1371/journal.pone.0158843 10.7326/0003-4819-155-8-201110180-00009 10.1136/thx.2009.131193 10.1378/chest.07-1342 10.1378/chest.11-0495 10.1155/2015/280187 10.1513/AnnalsATS.201307-243OC 10.1186/1471-2288-4-17 10.1136/thx.2007.083493 10.2147/COPD.S29892 10.1136/thx.2007.086371 10.3109/15412555.2014.949002 10.1378/chest.130.6.1687 10.1371/journal.pone.0105152 10.1378/chest.13-1809 10.1513/AnnalsATS.201408-365OC 10.1183/09031936.00072212 10.1164/rccm.201009-1414PP 10.1186/1465-9921-8-92 10.1378/chest.06-1610 10.1136/thoraxjnl-2015-207046 10.1111/imj.12984 10.1371/journal.pmed.0030442 10.3109/15412555.2012.668249 10.1183/09059180.00007212 10.1186/1477-7525-9-112 10.1164/rccm.201404-0713LE 10.1183/09031936.00128008 10.1186/s12916-016-0763-7 10.1136/thx.2006.062026 10.1378/chest.14-0655 10.1056/NEJMoa0909883 10.1378/chest.08-0520 10.1183/09031936.04.00014304 10.1183/09031936.00195212 10.1016/j.rmed.2004.11.012 10.1097/MAJ.0b013e3181bb8111 10.1378/chest.10-2521 10.1371/journal.pone.0109721 10.1016/j.rmed.2010.03.001 10.1183/16000617.0070-2016 10.1378/chest.07-2050 10.1183/09031936.03.00047003 10.1016/j.arbres.2011.04.011 10.1016/j.jamda.2011.06.009 10.1378/chest.07-2433 10.1378/chest.126.2.540 10.1136/thx.2006.072348 10.1164/rccm.201306-1170OC 10.1164/rccm.2107031 10.1378/chest.126.5.1443 10.4187/respcare.01440 10.1056/NEJMoa1411532 10.1164/rccm.201110-1792OC 10.1164/rccm.200804-560OC 10.1001/jama.2013.5732 10.1001/jama.283.15.2008 10.1059/0003-4819-155-8-201110180-00009 10.1055/s-0037-1613998 10.4187/respcare.02621 |
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| Copyright | Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2019 Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2019 |
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| DOI | 10.1136/thoraxjnl-2018-211855 |
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| Keywords | copd epidemiology |
| Language | English |
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| References | Cote, Dordelly, Celli (R39) 2007; 131 Monninkhof, van der Valk, van der Palen (R44) 2003; 22 Chung, Lake, Hyde (R5) 2016; 46 Whiting, Rutjes, Westwood (R23) 2011; 155 Cote, Pinto-Plata, Kasprzyk (R34) 2007; 132 Dahl, Vestbo, Zacho (R74) 2011; 66 Moore, Soler, Cetti (R57) 2010; 104 Tønnesen (R3) 2013; 22 Cano, Pichard, Roth (R69) 2004; 126 Cooper, Barjaktarevic, Curtis (R67) 2017 Valvi, Mannino, Müllerova (R48) 2012; 7 Ozgür, Nayci, Özge (R42) 2012; 57 Durheim, Smith, Babyak (R30) 2015; 12 Husebø, Bakke, Aanerud (R55) 2014; 9 Müllerova, Maselli, Locantore (R28) 2015; 147 Jennings, Digiovine, Obeid (R72) 2009; 187 Ferrari, Tanni, Caram (R26) 2013; 14 Warnier, Rutten, de Boer (R71) 2014; 9 Celli, Locantore, Yates (R31) 2012; 185 Grolimund, Kutz, Marlowe (R51) 2015; 12 Lange, Celli, Agustí (R10) 2015; 373 Dajczman, Wardini, Kasymjanova (R36) 2015; 22 Leuzzi, Galeone, Taverna (R19) 2017; 26 Casanova, Cote, Marin (R38) 2008; 134 (R2) 2012 Barnes, Celli (R17) 2009; 33 Hersh, DeMeo, Al-Ansari (R7) 2004; 126 Fisk, McEniery, Gale (R62) 2018; 71 Agusti, Sobradillo, Celli (R9) 2011; 183 Faganello, Tanni, Sanchez (R25) 2010; 339 de Torres, Pinto-Plata, Casanova (R33) 2008; 133 Wedzicha, Seemungal, MacCallum (R56) 2000; 84 Miller, Edwards, Agustí (R66) 2013; 107 Iwamoto, Yokoyama, Kitahara (R61) 2009; 179 Hurst, Vestbo, Anzueto (R53) 2010; 363 Vivodtzev, Tamisier, Baguet (R16) 2014; 145 Guevara, Berlin, Wolf (R65) 2004; 4 Spruit, Polkey, Celli (R27) 2012; 13 Mathers, Loncar (R1) 2006; 3 Crisafulli, Costi, Luppi (R6) 2008; 63 Thomsen, Ingebrigtsen, Marott (R47) 2013; 309 Patel, Kowlessar, Donaldson (R63) 2013; 188 Puhan, Gimeno-Santos, Scharplatz (R8) 2011; 10 Ferrari, Tanni, Caram (R41) 2011; 9 Celli, MacNee (R15) 2004; 23 Jensen, Marott, Lange (R46) 2013; 42 Marino, Marrara, Arcuri (R73) 2014; 18 Liu, Wang, Chin (R49) 2011; 47 Moy, Teylan, Danilack (R50) 2014; 11 Dreyse, Díaz, Repetto (R40) 2015; 10 Budweiser, Hitzl, Jörres (R54) 2007; 8 McGarvey, John, Anderson (R11) 2007; 62 Marquis, Debigaré, Lacasse (R14) 2002; 166 Koutsokera, Stolz, Loukides (R18) 2012; 141 Waschki, Kirsten, Holz (R37) 2011; 140 Chen, Leung, Sin (R20) 2016; 11 Pavasini, Guralnik, Brown (R58) 2016; 14 Groenewegen, Postma, Hop (R52) 2008; 133 Agusti, Edwards, Celli (R29) 2013; 42 Moher, Shamseer, Clarke (R21) 2015; 4 Blumenthal, Smith, Durheim (R32) 2016; 78 Mills, Miller, Anand (R64) 2008; 63 Cote, Casanova, Marín (R35) 2008; 31 Cinarka, Kayhan, Gumus (R60) 2013 Kon, Jones, Schofield (R59) 2015; 70 Mannino, Valvi, Mullerova (R43) 2012; 9 Patel, Natanek, Stratakos (R12) 2014; 190 Stroup, Berlin, Morton (R22) 2000; 283 Lacasse, Maltais, Poirier (R70) 2005; 99 Swallow, Reyes, Hopkinson (R13) 2007; 62 Antonelli-Incalzi, Corsonello, Pedone (R68) 2006; 130 Mathers, Loncar 2006; 3 Leuzzi, Galeone, Taverna 2017; 26 Swallow, Reyes, Hopkinson 2007; 62 Müllerova, Maselli, Locantore 2015; 147 Agusti, Edwards, Celli 2013; 42 Chung, Lake, Hyde 2016; 46 Celli, MacNee 2004; 23 Kon, Jones, Schofield 2015; 70 Guevara, Berlin, Wolf 2004; 4 McGarvey, John, Anderson 2007; 62 Grolimund, Kutz, Marlowe 2015; 12 Cote, Pinto-Plata, Kasprzyk 2007; 132 Hurst, Vestbo, Anzueto 2010; 363 Agusti, Sobradillo, Celli 2011; 183 Dahl, Vestbo, Zacho 2011; 66 Thomsen, Ingebrigtsen, Marott 2013; 309 Jennings, Digiovine, Obeid 2009; 187 Ferrari, Tanni, Caram 2013; 14 Antonelli-Incalzi, Corsonello, Pedone 2006; 130 Cooper, Barjaktarevic, Curtis 2017 Marino, Marrara, Arcuri 2014; 18 Blumenthal, Smith, Durheim 2016; 78 Moore, Soler, Cetti 2010; 104 Budweiser, Hitzl, Jörres 2007; 8 Husebø, Bakke, Aanerud 2014; 9 Vivodtzev, Tamisier, Baguet 2014; 145 Jensen, Marott, Lange 2013; 42 Celli, Locantore, Yates 2012; 185 Warnier, Rutten, de Boer 2014; 9 Ozgür, Nayci, Özge 2012; 57 Dajczman, Wardini, Kasymjanova 2015; 22 Monninkhof, van der Valk, van der Palen 2003; 22 Iwamoto, Yokoyama, Kitahara 2009; 179 Lange, Celli, Agustí 2015; 373 Whiting, Rutjes, Westwood 2011; 155 Groenewegen, Postma, Hop 2008; 133 Cote, Dordelly, Celli 2007; 131 Stroup, Berlin, Morton 2000; 283 2012 Crisafulli, Costi, Luppi 2008; 63 Patel, Natanek, Stratakos 2014; 190 Mills, Miller, Anand 2008; 63 Tønnesen 2013; 22 Pavasini, Guralnik, Brown 2016; 14 Lacasse, Maltais, Poirier 2005; 99 Chen, Leung, Sin 2016; 11 Durheim, Smith, Babyak 2015; 12 Liu, Wang, Chin 2011; 47 Cinarka, Kayhan, Gumus 2013 Moy, Teylan, Danilack 2014; 11 Miller, Edwards, Agustí 2013; 107 Cote, Casanova, Marín 2008; 31 Moher, Shamseer, Clarke 2015; 4 Waschki, Kirsten, Holz 2011; 140 Faganello, Tanni, Sanchez 2010; 339 Fisk, McEniery, Gale 2018; 71 Casanova, Cote, Marin 2008; 134 Patel, Kowlessar, Donaldson 2013; 188 Mannino, Valvi, Mullerova 2012; 9 Valvi, Mannino, Müllerova 2012; 7 Ferrari, Tanni, Caram 2011; 9 Marquis, Debigaré, Lacasse 2002; 166 Wedzicha, Seemungal, MacCallum 2000; 84 Cano, Pichard, Roth 2004; 126 Puhan, Gimeno-Santos, Scharplatz 2011; 10 Spruit, Polkey, Celli 2012; 13 de Torres, Pinto-Plata, Casanova 2008; 133 2016 Barnes, Celli 2009; 33 Dreyse, Díaz, Repetto 2015; 10 Hersh, DeMeo, Al-Ansari 2004; 126 Koutsokera, Stolz, Loukides 2012; 141 2024092104351367000_74.5.439.10 2024092104351367000_74.5.439.54 2024092104351367000_74.5.439.53 Pavasini (2024092104351367000_74.5.439.58) 2016; 14 2024092104351367000_74.5.439.12 2024092104351367000_74.5.439.11 2024092104351367000_74.5.439.52 Moy (2024092104351367000_74.5.439.50) 2014; 11 Warnier (2024092104351367000_74.5.439.71) 2014; 9 2024092104351367000_74.5.439.47 Chen (2024092104351367000_74.5.439.20) 2016; 11 2024092104351367000_74.5.439.46 2024092104351367000_74.5.439.49 Husebø (2024092104351367000_74.5.439.55) 2014; 9 Faganello (2024092104351367000_74.5.439.25) 2010; 339 2024092104351367000_74.5.439.42 2024092104351367000_74.5.439.45 2024092104351367000_74.5.439.44 2024092104351367000_74.5.439.39 2024092104351367000_74.5.439.35 Fisk (2024092104351367000_74.5.439.62) 2018; 71 2024092104351367000_74.5.439.38 2024092104351367000_74.5.439.37 Wedzicha (2024092104351367000_74.5.439.56) 2000; 84 2024092104351367000_74.5.439.70 Valvi (2024092104351367000_74.5.439.48) 2012; 7 2024092104351367000_74.5.439.31 2024092104351367000_74.5.439.34 2024092104351367000_74.5.439.33 2024092104351367000_74.5.439.30 2024092104351367000_74.5.439.74 2024092104351367000_74.5.439.29 2024092104351367000_74.5.439.28 Grolimund (2024092104351367000_74.5.439.51) 2015; 12 2024092104351367000_74.5.439.69 2024092104351367000_74.5.439.24 2024092104351367000_74.5.439.68 2024092104351367000_74.5.439.27 Ferrari (2024092104351367000_74.5.439.41) 2011; 9 Marino (2024092104351367000_74.5.439.73) 2014; 18 2024092104351367000_74.5.439.26 2024092104351367000_74.5.439.4 2024092104351367000_74.5.439.3 Puhan (2024092104351367000_74.5.439.8) 2011; 10 2024092104351367000_74.5.439.2 2024092104351367000_74.5.439.1 Jennings (2024092104351367000_74.5.439.72) 2009; 187 2024092104351367000_74.5.439.21 2024092104351367000_74.5.439.65 Dreyse (2024092104351367000_74.5.439.40) 2015; 10 2024092104351367000_74.5.439.64 2024092104351367000_74.5.439.23 Mannino (2024092104351367000_74.5.439.43) 2012; 9 2024092104351367000_74.5.439.67 2024092104351367000_74.5.439.22 2024092104351367000_74.5.439.66 2024092104351367000_74.5.439.9 2024092104351367000_74.5.439.61 2024092104351367000_74.5.439.60 2024092104351367000_74.5.439.7 2024092104351367000_74.5.439.63 2024092104351367000_74.5.439.6 2024092104351367000_74.5.439.18 2024092104351367000_74.5.439.17 Dajczman (2024092104351367000_74.5.439.36) 2015; 22 2024092104351367000_74.5.439.19 2024092104351367000_74.5.439.14 Blumenthal (2024092104351367000_74.5.439.32) 2016; 78 Chung (2024092104351367000_74.5.439.5) 2016; 46 2024092104351367000_74.5.439.13 2024092104351367000_74.5.439.57 2024092104351367000_74.5.439.16 2024092104351367000_74.5.439.15 2024092104351367000_74.5.439.59 |
| References_xml | – volume: 4 start-page: 1 year: 2015 ident: R21 article-title: Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement publication-title: Syst Rev doi: 10.1186/2046-4053-4-1 – volume: 71 start-page: 499 year: 2018 ident: R62 article-title: Surrogate markers of cardiovascular risk and chronic obstructive pulmonary disease: A large case-controlled study publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.117.10151 – volume: 78 start-page: 153 year: 2016 ident: R32 article-title: Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial publication-title: Psychosom Med doi: 10.1097/PSY.0000000000000260 – volume: 107 start-page: 1376 year: 2013 ident: R66 article-title: Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort publication-title: Respir Med doi: 10.1016/j.rmed.2013.05.001 – volume: 187 start-page: 128 year: 2009 ident: R72 article-title: The association between depressive symptoms and acute exacerbations of COPD publication-title: Lung doi: 10.1007/s00408-009-9135-9 – volume: 18 start-page: 127 year: 2014 ident: R73 article-title: Determination of exacerbation predictors in patients with COPD in physical therapy - a longitudinal study publication-title: Braz J Phys Ther doi: 10.1590/S1413-35552012005000146 – volume: 14 start-page: 24 year: 2013 ident: R26 article-title: Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease publication-title: Respir Res doi: 10.1186/1465-9921-14-24 – volume: 10 start-page: 525 year: 2015 ident: R40 article-title: Do frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers? publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S76475 – volume: 31 start-page: 571 year: 2008 ident: R35 article-title: Validation and comparison of reference equations for the 6-min walk distance test publication-title: Eur Respir J doi: 10.1183/09031936.00104507 – volume: 11 year: 2016 ident: R20 article-title: A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation publication-title: PLoS One doi: 10.1371/journal.pone.0158843 – volume: 155 start-page: 529 year: 2011 ident: R23 article-title: QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies publication-title: Ann Intern Med doi: 10.7326/0003-4819-155-8-201110180-00009 – volume: 66 start-page: 197 year: 2011 ident: R74 article-title: C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach publication-title: Thorax doi: 10.1136/thx.2009.131193 – year: 2013 ident: R60 article-title: Arterial stiffness measured by carotid femoral pulse wave velocity is associated with disease severity in chronic obstructive pulmonary disease publication-title: Respiratory Care – volume: 133 start-page: 350 year: 2008 ident: R52 article-title: Increased systemic inflammation is a risk factor for COPD exacerbations publication-title: Chest doi: 10.1378/chest.07-1342 – volume: 141 start-page: 396 year: 2012 ident: R18 article-title: Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge publication-title: Chest doi: 10.1378/chest.11-0495 – volume: 22 start-page: 225 year: 2015 ident: R36 article-title: Six minute walk distance is a predictor of survival in patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation publication-title: Can Respir J doi: 10.1155/2015/280187 – volume: 11 start-page: 149 year: 2014 ident: R50 article-title: An index of daily step count and systemic inflammation predicts clinical outcomes in chronic obstructive pulmonary disease publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201307-243OC – volume: 4 start-page: 17 year: 2004 ident: R65 article-title: Meta-analytic methods for pooling rates when follow-up duration varies: a case study publication-title: BMC Med Res Methodol doi: 10.1186/1471-2288-4-17 – volume: 63 start-page: 306 year: 2008 ident: R64 article-title: Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk publication-title: Thorax doi: 10.1136/thx.2007.083493 – volume: 7 start-page: 173 year: 2012 ident: R48 article-title: Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S29892 – volume: 63 start-page: 487 year: 2008 ident: R6 article-title: Role of comorbidities in a cohort of patients with COPD undergoing pulmonary rehabilitation publication-title: Thorax doi: 10.1136/thx.2007.086371 – volume: 12 start-page: 300 year: 2015 ident: R51 article-title: Long-term prognosis in copd exacerbation: Role of biomarkers, clinical variables and exacerbation type publication-title: COPD doi: 10.3109/15412555.2014.949002 – volume: 130 start-page: 1687 year: 2006 ident: R68 article-title: Drawing impairment predicts mortality in severe COPD publication-title: Chest doi: 10.1378/chest.130.6.1687 – volume: 9 start-page: e105152 year: 2014 ident: R71 article-title: Resting heart rate is a risk factor for mortality in chronic obstructive pulmonary disease, but not for exacerbations or pneumonia publication-title: PLoS One doi: 10.1371/journal.pone.0105152 – volume: 145 start-page: 861 year: 2014 ident: R16 article-title: Arterial stiffness in COPD publication-title: Chest doi: 10.1378/chest.13-1809 – volume: 12 start-page: 349 year: 2015 ident: R30 article-title: Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201408-365OC – volume: 42 start-page: 341 year: 2013 ident: R46 article-title: Resting heart rate is a predictor of mortality in COPD publication-title: Eur Respir J doi: 10.1183/09031936.00072212 – volume: 283 start-page: 2008 year: 2000 ident: R22 article-title: Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group publication-title: JAMA – volume: 183 start-page: 1129 year: 2011 ident: R9 article-title: Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201009-1414PP – volume: 8 start-page: 92 year: 2007 ident: R54 article-title: Health-related quality of life and long-term prognosis in chronic hypercapnic respiratory failure: a prospective survival analysis publication-title: Respir Res doi: 10.1186/1465-9921-8-92 – volume: 131 start-page: 696 year: 2007 ident: R39 article-title: Impact of COPD exacerbations on patient-centered outcomes publication-title: Chest doi: 10.1378/chest.06-1610 – volume: 70 start-page: 1131 year: 2015 ident: R59 article-title: Gait speed and readmission following hospitalisation for acute exacerbations of COPD: a prospective study publication-title: Thorax doi: 10.1136/thoraxjnl-2015-207046 – volume: 46 start-page: 427 year: 2016 ident: R5 article-title: Integrated multidisciplinary community service for chronic obstructive pulmonary disease reduces hospitalisations publication-title: Intern Med J doi: 10.1111/imj.12984 – volume: 3 start-page: e442 year: 2006 ident: R1 article-title: Projections of global mortality and burden of disease from 2002 to 2030 publication-title: PLoS Med doi: 10.1371/journal.pmed.0030442 – volume: 9 start-page: 359 year: 2012 ident: R43 article-title: Fibrinogen, COPD and mortality in a nationally representative U.S. cohort publication-title: COPD doi: 10.3109/15412555.2012.668249 – volume: 22 start-page: 37 year: 2013 ident: R3 article-title: Smoking cessation and COPD publication-title: Eur Respir Rev doi: 10.1183/09059180.00007212 – volume: 9 start-page: 112 year: 2011 ident: R41 article-title: Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease publication-title: Health Qual Life Outcomes doi: 10.1186/1477-7525-9-112 – volume: 190 start-page: 350 year: 2014 ident: R12 article-title: Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201404-0713LE – volume: 33 start-page: 1165 year: 2009 ident: R17 article-title: Systemic manifestations and comorbidities of COPD publication-title: Eur Respir J doi: 10.1183/09031936.00128008 – volume: 14 start-page: 215 year: 2016 ident: R58 article-title: Short physical performance battery and all-cause mortality: systematic review and meta-analysis publication-title: BMC Med doi: 10.1186/s12916-016-0763-7 – volume: 62 start-page: 115 year: 2007 ident: R13 article-title: Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease publication-title: Thorax doi: 10.1136/thx.2006.062026 – volume: 147 start-page: 999 year: 2015 ident: R28 article-title: Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort publication-title: Chest doi: 10.1378/chest.14-0655 – volume: 363 start-page: 1128 year: 2010 ident: R53 article-title: Susceptibility to exacerbation in chronic obstructive pulmonary disease publication-title: N Engl J Med doi: 10.1056/NEJMoa0909883 – volume: 134 start-page: 746 year: 2008 ident: R38 article-title: Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD publication-title: Chest doi: 10.1378/chest.08-0520 – volume: 23 start-page: 932 year: 2004 ident: R15 article-title: Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper publication-title: Eur Respir J doi: 10.1183/09031936.04.00014304 – volume: 42 start-page: 636 year: 2013 ident: R29 article-title: Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort publication-title: Eur Respir J doi: 10.1183/09031936.00195212 – start-page: A2721 year: 2017 ident: R67 article-title: A Novel Debility Score Predicts Future Exacerbations And Death In SPIROMICS. A103 COPD: DISEASE PROGRESSION AND PROGNOSIS publication-title: Am Thoracic Soc – volume: 99 start-page: 877 year: 2005 ident: R70 article-title: Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease publication-title: Respir Med doi: 10.1016/j.rmed.2004.11.012 – year: 2012 ident: R2 article-title: British Thoracic Society and the Primary Care Respiratory Society UK publication-title: IMPRESS Guide to the relative value of COPD interventions – volume: 339 start-page: 10 year: 2010 ident: R25 article-title: BODE index and GOLD staging as predictors of 1-year exacerbation risk in chronic obstructive pulmonary disease publication-title: Am J Med Sci doi: 10.1097/MAJ.0b013e3181bb8111 – volume: 140 start-page: 331 year: 2011 ident: R37 article-title: Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study publication-title: Chest doi: 10.1378/chest.10-2521 – volume: 9 year: 2014 ident: R55 article-title: Predictors of exacerbations in chronic obstructive pulmonary disease-results from the Bergen COPD cohort study publication-title: PLoS One doi: 10.1371/journal.pone.0109721 – volume: 104 start-page: 1319 year: 2010 ident: R57 article-title: Sniff nasal inspiratory pressure versus IC/TLC ratio as predictors of mortality in COPD publication-title: Respir Med doi: 10.1016/j.rmed.2010.03.001 – volume: 26 start-page: 160070 year: 2017 ident: R19 article-title: C-reactive protein level predicts mortality in COPD: a systematic review and meta-analysis publication-title: Eur Respir Rev doi: 10.1183/16000617.0070-2016 – volume: 132 start-page: 1778 year: 2007 ident: R34 article-title: The 6-min walk distance, peak oxygen uptake, and mortality in COPD publication-title: Chest doi: 10.1378/chest.07-2050 – volume: 22 start-page: 815 year: 2003 ident: R44 article-title: Effects of a comprehensive self-management programme in patients with chronic obstructive pulmonary disease publication-title: Eur Respir J doi: 10.1183/09031936.03.00047003 – volume: 10 start-page: CD005305 year: 2011 ident: R8 article-title: Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease publication-title: Cochrane Database Syst Rev – volume: 47 start-page: 427 year: 2011 ident: R49 article-title: High value of combined serum C-reactive protein and BODE score for mortality prediction in patients with stable COPD publication-title: Arch Bronconeumol doi: 10.1016/j.arbres.2011.04.011 – volume: 13 start-page: 291 year: 2012 ident: R27 article-title: Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2011.06.009 – volume: 133 start-page: 1336 year: 2008 ident: R33 article-title: C-reactive protein levels and survival in patients with moderate to very severe COPD publication-title: Chest doi: 10.1378/chest.07-2433 – volume: 126 start-page: 540 year: 2004 ident: R69 article-title: C-reactive protein and body mass index predict outcome in end-stage respiratory failure publication-title: Chest doi: 10.1378/chest.126.2.540 – volume: 62 start-page: 411 year: 2007 ident: R11 article-title: Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee publication-title: Thorax doi: 10.1136/thx.2006.072348 – volume: 188 start-page: 1091 year: 2013 ident: R63 article-title: Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201306-1170OC – volume: 166 start-page: 809 year: 2002 ident: R14 article-title: Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.2107031 – volume: 126 start-page: 1443 year: 2004 ident: R7 article-title: Predictors of survival in severe, early onset COPD publication-title: Chest doi: 10.1378/chest.126.5.1443 – volume: 57 start-page: 1452 year: 2012 ident: R42 article-title: An integrated index combined by dynamic hyperinflation and exercise capacity in the prediction of morbidity and mortality in COPD publication-title: Respir Care doi: 10.4187/respcare.01440 – volume: 373 start-page: 111 year: 2015 ident: R10 article-title: Lung-function trajectories leading to chronic obstructive pulmonary disease publication-title: N Engl J Med doi: 10.1056/NEJMoa1411532 – volume: 185 start-page: 1065 year: 2012 ident: R31 article-title: Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201110-1792OC – volume: 179 start-page: 35 year: 2009 ident: R61 article-title: Airflow limitation in smokers is associated with subclinical atherosclerosis publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200804-560OC – volume: 84 start-page: 210 year: 2000 ident: R56 article-title: Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels publication-title: Thromb Haemost – volume: 309 start-page: 2353 year: 2013 ident: R47 article-title: Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease publication-title: JAMA doi: 10.1001/jama.2013.5732 – volume: 130 start-page: 1687 year: 2006 article-title: Drawing impairment predicts mortality in severe COPD publication-title: Chest doi: 10.1378/chest.130.6.1687 – volume: 71 start-page: 499 year: 2018 article-title: Surrogate markers of cardiovascular risk and chronic obstructive pulmonary disease: A large case-controlled study publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.117.10151 – volume: 188 start-page: 1091 year: 2013 article-title: Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201306-1170OC – volume: 63 start-page: 487 year: 2008 article-title: Role of comorbidities in a cohort of patients with COPD undergoing pulmonary rehabilitation publication-title: Thorax doi: 10.1136/thx.2007.086371 – volume: 190 start-page: 350 year: 2014 article-title: Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201404-0713LE – volume: 13 start-page: 291 year: 2012 article-title: Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2011.06.009 – volume: 8 start-page: 92 year: 2007 article-title: Health-related quality of life and long-term prognosis in chronic hypercapnic respiratory failure: a prospective survival analysis publication-title: Respir Res doi: 10.1186/1465-9921-8-92 – volume: 9 start-page: 112 year: 2011 article-title: Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease publication-title: Health Qual Life Outcomes doi: 10.1186/1477-7525-9-112 – volume: 26 start-page: 160070 year: 2017 article-title: C-reactive protein level predicts mortality in COPD: a systematic review and meta-analysis publication-title: Eur Respir Rev doi: 10.1183/16000617.0070-2016 – volume: 131 start-page: 696 year: 2007 article-title: Impact of COPD exacerbations on patient-centered outcomes publication-title: Chest doi: 10.1378/chest.06-1610 – volume: 11 start-page: 149 year: 2014 article-title: An index of daily step count and systemic inflammation predicts clinical outcomes in chronic obstructive pulmonary disease publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201307-243OC – volume: 107 start-page: 1376 year: 2013 article-title: Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort publication-title: Respir Med doi: 10.1016/j.rmed.2013.05.001 – volume: 9 start-page: 359 year: 2012 article-title: Fibrinogen, COPD and mortality in a nationally representative U.S. cohort publication-title: COPD doi: 10.3109/15412555.2012.668249 – volume: 183 start-page: 1129 year: 2011 article-title: Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201009-1414PP – volume: 339 start-page: 10 year: 2010 article-title: BODE index and GOLD staging as predictors of 1-year exacerbation risk in chronic obstructive pulmonary disease publication-title: Am J Med Sci doi: 10.1097/MAJ.0b013e3181bb8111 – volume: 66 start-page: 197 year: 2011 article-title: C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach publication-title: Thorax doi: 10.1136/thx.2009.131193 – volume: 78 start-page: 153 year: 2016 article-title: Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial publication-title: Psychosom Med doi: 10.1097/PSY.0000000000000260 – volume: 147 start-page: 999 year: 2015 article-title: Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort publication-title: Chest doi: 10.1378/chest.14-0655 – volume: 133 start-page: 1336 year: 2008 article-title: C-reactive protein levels and survival in patients with moderate to very severe COPD publication-title: Chest doi: 10.1378/chest.07-2433 – volume: 22 start-page: 225 year: 2015 article-title: Six minute walk distance is a predictor of survival in patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation publication-title: Can Respir J doi: 10.1155/2015/280187 – volume: 283 start-page: 2008 year: 2000 article-title: Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group publication-title: JAMA – volume: 179 start-page: 35 year: 2009 article-title: Airflow limitation in smokers is associated with subclinical atherosclerosis publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200804-560OC – volume: 309 start-page: 2353 year: 2013 article-title: Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease publication-title: JAMA doi: 10.1001/jama.2013.5732 – volume: 155 start-page: 529 year: 2011 article-title: QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies publication-title: Ann Intern Med doi: 10.7326/0003-4819-155-8-201110180-00009 – volume: 33 start-page: 1165 year: 2009 article-title: Systemic manifestations and comorbidities of COPD publication-title: Eur Respir J doi: 10.1183/09031936.00128008 – volume: 42 start-page: 341 year: 2013 article-title: Resting heart rate is a predictor of mortality in COPD publication-title: Eur Respir J doi: 10.1183/09031936.00072212 – year: 2013 article-title: Arterial stiffness measured by carotid femoral pulse wave velocity is associated with disease severity in chronic obstructive pulmonary disease publication-title: Respiratory Care – volume: 11 year: 2016 article-title: A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation publication-title: PLoS One doi: 10.1371/journal.pone.0158843 – volume: 145 start-page: 861 year: 2014 article-title: Arterial stiffness in COPD publication-title: Chest doi: 10.1378/chest.13-1809 – volume: 23 start-page: 932 year: 2004 article-title: Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper publication-title: Eur Respir J doi: 10.1183/09031936.04.00014304 – volume: 12 start-page: 300 year: 2015 article-title: Long-term prognosis in copd exacerbation: Role of biomarkers, clinical variables and exacerbation type publication-title: COPD doi: 10.3109/15412555.2014.949002 – volume: 10 start-page: 525 year: 2015 article-title: Do frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers? publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S76475 – volume: 132 start-page: 1778 year: 2007 article-title: The 6-min walk distance, peak oxygen uptake, and mortality in COPD publication-title: Chest doi: 10.1378/chest.07-2050 – volume: 3 start-page: e442 year: 2006 article-title: Projections of global mortality and burden of disease from 2002 to 2030 publication-title: PLoS Med doi: 10.1371/journal.pmed.0030442 – volume: 14 start-page: 24 year: 2013 article-title: Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease publication-title: Respir Res doi: 10.1186/1465-9921-14-24 – volume: 47 start-page: 427 year: 2011 article-title: High value of combined serum C-reactive protein and BODE score for mortality prediction in patients with stable COPD publication-title: Arch Bronconeumol doi: 10.1016/j.arbres.2011.04.011 – start-page: A2721 year: 2017 article-title: A Novel Debility Score Predicts Future Exacerbations And Death In SPIROMICS. A103 COPD: DISEASE PROGRESSION AND PROGNOSIS publication-title: Am Thoracic Soc – volume: 99 start-page: 877 year: 2005 article-title: Post-exercise heart rate recovery and mortality in chronic obstructive pulmonary disease publication-title: Respir Med doi: 10.1016/j.rmed.2004.11.012 – volume: 126 start-page: 1443 year: 2004 article-title: Predictors of survival in severe, early onset COPD publication-title: Chest doi: 10.1378/chest.126.5.1443 – volume: 166 start-page: 809 year: 2002 article-title: Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.2107031 – volume: 46 start-page: 427 year: 2016 article-title: Integrated multidisciplinary community service for chronic obstructive pulmonary disease reduces hospitalisations publication-title: Intern Med J doi: 10.1111/imj.12984 – volume: 4 start-page: 17 year: 2004 article-title: Meta-analytic methods for pooling rates when follow-up duration varies: a case study publication-title: BMC Med Res Methodol doi: 10.1186/1471-2288-4-17 – volume: 31 start-page: 571 year: 2008 article-title: Validation and comparison of reference equations for the 6-min walk distance test publication-title: Eur Respir J doi: 10.1183/09031936.00104507 – volume: 10 start-page: CD005305 year: 2011 article-title: Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease publication-title: Cochrane Database Syst Rev – volume: 22 start-page: 37 year: 2013 article-title: Smoking cessation and COPD publication-title: Eur Respir Rev doi: 10.1183/09059180.00007212 – volume: 63 start-page: 306 year: 2008 article-title: Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk publication-title: Thorax doi: 10.1136/thx.2007.083493 – volume: 7 start-page: 173 year: 2012 article-title: Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S29892 – volume: 363 start-page: 1128 year: 2010 article-title: Susceptibility to exacerbation in chronic obstructive pulmonary disease publication-title: N Engl J Med doi: 10.1056/NEJMoa0909883 – year: 2012 article-title: British Thoracic Society and the Primary Care Respiratory Society UK publication-title: IMPRESS Guide to the relative value of COPD interventions – volume: 104 start-page: 1319 year: 2010 article-title: Sniff nasal inspiratory pressure versus IC/TLC ratio as predictors of mortality in COPD publication-title: Respir Med doi: 10.1016/j.rmed.2010.03.001 – volume: 57 start-page: 1452 year: 2012 article-title: An integrated index combined by dynamic hyperinflation and exercise capacity in the prediction of morbidity and mortality in COPD publication-title: Respir Care doi: 10.4187/respcare.01440 – volume: 187 start-page: 128 year: 2009 article-title: The association between depressive symptoms and acute exacerbations of COPD publication-title: Lung doi: 10.1007/s00408-009-9135-9 – volume: 9 year: 2014 article-title: Predictors of exacerbations in chronic obstructive pulmonary disease-results from the Bergen COPD cohort study publication-title: PLoS One doi: 10.1371/journal.pone.0109721 – volume: 62 start-page: 411 year: 2007 article-title: Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee publication-title: Thorax doi: 10.1136/thx.2006.072348 – volume: 12 start-page: 349 year: 2015 article-title: Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201408-365OC – volume: 126 start-page: 540 year: 2004 article-title: C-reactive protein and body mass index predict outcome in end-stage respiratory failure publication-title: Chest doi: 10.1378/chest.126.2.540 – volume: 141 start-page: 396 year: 2012 article-title: Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge publication-title: Chest doi: 10.1378/chest.11-0495 – volume: 70 start-page: 1131 year: 2015 article-title: Gait speed and readmission following hospitalisation for acute exacerbations of COPD: a prospective study publication-title: Thorax doi: 10.1136/thoraxjnl-2015-207046 – volume: 18 start-page: 127 year: 2014 article-title: Determination of exacerbation predictors in patients with COPD in physical therapy - a longitudinal study publication-title: Braz J Phys Ther doi: 10.1590/S1413-35552012005000146 – volume: 373 start-page: 111 year: 2015 article-title: Lung-function trajectories leading to chronic obstructive pulmonary disease publication-title: N Engl J Med doi: 10.1056/NEJMoa1411532 – volume: 4 start-page: 1 year: 2015 article-title: Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement publication-title: Syst Rev doi: 10.1186/2046-4053-4-1 – volume: 9 start-page: e105152 year: 2014 article-title: Resting heart rate is a risk factor for mortality in chronic obstructive pulmonary disease, but not for exacerbations or pneumonia publication-title: PLoS One doi: 10.1371/journal.pone.0105152 – volume: 134 start-page: 746 year: 2008 article-title: Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD publication-title: Chest doi: 10.1378/chest.08-0520 – volume: 14 start-page: 215 year: 2016 article-title: Short physical performance battery and all-cause mortality: systematic review and meta-analysis publication-title: BMC Med doi: 10.1186/s12916-016-0763-7 – volume: 133 start-page: 350 year: 2008 article-title: Increased systemic inflammation is a risk factor for COPD exacerbations publication-title: Chest doi: 10.1378/chest.07-1342 – volume: 42 start-page: 636 year: 2013 article-title: Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort publication-title: Eur Respir J doi: 10.1183/09031936.00195212 – volume: 185 start-page: 1065 year: 2012 article-title: Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201110-1792OC – volume: 140 start-page: 331 year: 2011 article-title: Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study publication-title: Chest doi: 10.1378/chest.10-2521 – volume: 22 start-page: 815 year: 2003 article-title: Effects of a comprehensive self-management programme in patients with chronic obstructive pulmonary disease publication-title: Eur Respir J doi: 10.1183/09031936.03.00047003 – volume: 84 start-page: 210 year: 2000 article-title: Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels publication-title: Thromb Haemost – volume: 62 start-page: 115 year: 2007 article-title: Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease publication-title: Thorax doi: 10.1136/thx.2006.062026 – year: 2016 article-title: Global strategy for the diagnosis, management and prevention of COPD – ident: 2024092104351367000_74.5.439.19 doi: 10.1183/16000617.0070-2016 – ident: 2024092104351367000_74.5.439.68 doi: 10.1378/chest.130.6.1687 – ident: 2024092104351367000_74.5.439.18 doi: 10.1378/chest.11-0495 – ident: 2024092104351367000_74.5.439.67 – ident: 2024092104351367000_74.5.439.35 doi: 10.1183/09031936.00104507 – ident: 2024092104351367000_74.5.439.38 doi: 10.1378/chest.08-0520 – ident: 2024092104351367000_74.5.439.39 doi: 10.1378/chest.06-1610 – volume: 9 year: 2014 ident: 2024092104351367000_74.5.439.55 article-title: Predictors of exacerbations in chronic obstructive pulmonary disease-results from the Bergen COPD cohort study publication-title: PLoS One doi: 10.1371/journal.pone.0109721 – ident: 2024092104351367000_74.5.439.1 doi: 10.1371/journal.pmed.0030442 – ident: 2024092104351367000_74.5.439.24 – ident: 2024092104351367000_74.5.439.65 doi: 10.1186/1471-2288-4-17 – ident: 2024092104351367000_74.5.439.61 doi: 10.1164/rccm.200804-560OC – ident: 2024092104351367000_74.5.439.59 doi: 10.1136/thoraxjnl-2015-207046 – volume: 71 start-page: 499 year: 2018 ident: 2024092104351367000_74.5.439.62 article-title: Surrogate markers of cardiovascular risk and chronic obstructive pulmonary disease: A large case-controlled study publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.117.10151 – ident: 2024092104351367000_74.5.439.37 doi: 10.1378/chest.10-2521 – ident: 2024092104351367000_74.5.439.53 doi: 10.1056/NEJMoa0909883 – ident: 2024092104351367000_74.5.439.14 doi: 10.1164/rccm.2107031 – ident: 2024092104351367000_74.5.439.66 doi: 10.1016/j.rmed.2013.05.001 – ident: 2024092104351367000_74.5.439.34 doi: 10.1378/chest.07-2050 – ident: 2024092104351367000_74.5.439.9 doi: 10.1164/rccm.201009-1414PP – ident: 2024092104351367000_74.5.439.31 doi: 10.1164/rccm.201110-1792OC – ident: 2024092104351367000_74.5.439.4 – ident: 2024092104351367000_74.5.439.46 doi: 10.1183/09031936.00072212 – ident: 2024092104351367000_74.5.439.3 doi: 10.1183/09059180.00007212 – volume: 46 start-page: 427 year: 2016 ident: 2024092104351367000_74.5.439.5 article-title: Integrated multidisciplinary community service for chronic obstructive pulmonary disease reduces hospitalisations publication-title: Intern Med J doi: 10.1111/imj.12984 – volume: 22 start-page: 225 year: 2015 ident: 2024092104351367000_74.5.439.36 article-title: Six minute walk distance is a predictor of survival in patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation publication-title: Can Respir J doi: 10.1155/2015/280187 – ident: 2024092104351367000_74.5.439.21 doi: 10.1186/2046-4053-4-1 – ident: 2024092104351367000_74.5.439.28 doi: 10.1378/chest.14-0655 – ident: 2024092104351367000_74.5.439.7 doi: 10.1378/chest.126.5.1443 – volume: 18 start-page: 127 year: 2014 ident: 2024092104351367000_74.5.439.73 article-title: Determination of exacerbation predictors in patients with COPD in physical therapy - a longitudinal study publication-title: Braz J Phys Ther doi: 10.1590/S1413-35552012005000146 – ident: 2024092104351367000_74.5.439.33 doi: 10.1378/chest.07-2433 – volume: 187 start-page: 128 year: 2009 ident: 2024092104351367000_74.5.439.72 article-title: The association between depressive symptoms and acute exacerbations of COPD publication-title: Lung doi: 10.1007/s00408-009-9135-9 – ident: 2024092104351367000_74.5.439.63 doi: 10.1164/rccm.201306-1170OC – ident: 2024092104351367000_74.5.439.64 doi: 10.1136/thx.2007.083493 – ident: 2024092104351367000_74.5.439.29 doi: 10.1183/09031936.00195212 – ident: 2024092104351367000_74.5.439.22 doi: 10.1001/jama.283.15.2008 – ident: 2024092104351367000_74.5.439.42 doi: 10.4187/respcare.01440 – ident: 2024092104351367000_74.5.439.17 doi: 10.1183/09031936.00128008 – ident: 2024092104351367000_74.5.439.74 doi: 10.1136/thx.2009.131193 – volume: 9 start-page: e105152 year: 2014 ident: 2024092104351367000_74.5.439.71 article-title: Resting heart rate is a risk factor for mortality in chronic obstructive pulmonary disease, but not for exacerbations or pneumonia publication-title: PLoS One doi: 10.1371/journal.pone.0105152 – ident: 2024092104351367000_74.5.439.44 doi: 10.1183/09031936.03.00047003 – ident: 2024092104351367000_74.5.439.23 doi: 10.1059/0003-4819-155-8-201110180-00009 – ident: 2024092104351367000_74.5.439.52 doi: 10.1378/chest.07-1342 – ident: 2024092104351367000_74.5.439.49 doi: 10.1016/j.arbres.2011.04.011 – ident: 2024092104351367000_74.5.439.11 doi: 10.1136/thx.2006.072348 – ident: 2024092104351367000_74.5.439.27 doi: 10.1016/j.jamda.2011.06.009 – volume: 10 start-page: CD005305 year: 2011 ident: 2024092104351367000_74.5.439.8 article-title: Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease publication-title: Cochrane Database Syst Rev – volume: 10 start-page: 525 year: 2015 ident: 2024092104351367000_74.5.439.40 article-title: Do frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers? publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S76475 – volume: 14 start-page: 215 year: 2016 ident: 2024092104351367000_74.5.439.58 article-title: Short physical performance battery and all-cause mortality: systematic review and meta-analysis publication-title: BMC Med doi: 10.1186/s12916-016-0763-7 – ident: 2024092104351367000_74.5.439.15 doi: 10.1183/09031936.04.00014304 – volume: 339 start-page: 10 year: 2010 ident: 2024092104351367000_74.5.439.25 article-title: BODE index and GOLD staging as predictors of 1-year exacerbation risk in chronic obstructive pulmonary disease publication-title: Am J Med Sci doi: 10.1097/MAJ.0b013e3181bb8111 – volume: 11 year: 2016 ident: 2024092104351367000_74.5.439.20 article-title: A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation publication-title: PLoS One doi: 10.1371/journal.pone.0158843 – ident: 2024092104351367000_74.5.439.10 doi: 10.1056/NEJMoa1411532 – ident: 2024092104351367000_74.5.439.6 doi: 10.1136/thx.2007.086371 – volume: 9 start-page: 112 year: 2011 ident: 2024092104351367000_74.5.439.41 article-title: Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease publication-title: Health Qual Life Outcomes doi: 10.1186/1477-7525-9-112 – ident: 2024092104351367000_74.5.439.12 doi: 10.1164/rccm.201404-0713LE – ident: 2024092104351367000_74.5.439.47 doi: 10.1001/jama.2013.5732 – ident: 2024092104351367000_74.5.439.30 doi: 10.1513/AnnalsATS.201408-365OC – volume: 11 start-page: 149 year: 2014 ident: 2024092104351367000_74.5.439.50 article-title: An index of daily step count and systemic inflammation predicts clinical outcomes in chronic obstructive pulmonary disease publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201307-243OC – volume: 12 start-page: 300 year: 2015 ident: 2024092104351367000_74.5.439.51 article-title: Long-term prognosis in copd exacerbation: Role of biomarkers, clinical variables and exacerbation type publication-title: COPD doi: 10.3109/15412555.2014.949002 – ident: 2024092104351367000_74.5.439.57 doi: 10.1016/j.rmed.2010.03.001 – ident: 2024092104351367000_74.5.439.70 doi: 10.1016/j.rmed.2004.11.012 – volume: 9 start-page: 359 year: 2012 ident: 2024092104351367000_74.5.439.43 article-title: Fibrinogen, COPD and mortality in a nationally representative U.S. cohort publication-title: COPD doi: 10.3109/15412555.2012.668249 – ident: 2024092104351367000_74.5.439.45 – volume: 78 start-page: 153 year: 2016 ident: 2024092104351367000_74.5.439.32 article-title: Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial publication-title: Psychosom Med doi: 10.1097/PSY.0000000000000260 – volume: 84 start-page: 210 year: 2000 ident: 2024092104351367000_74.5.439.56 article-title: Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels publication-title: Thromb Haemost doi: 10.1055/s-0037-1613998 – ident: 2024092104351367000_74.5.439.60 doi: 10.4187/respcare.02621 – ident: 2024092104351367000_74.5.439.69 doi: 10.1378/chest.126.2.540 – ident: 2024092104351367000_74.5.439.13 doi: 10.1136/thx.2006.062026 – ident: 2024092104351367000_74.5.439.2 – ident: 2024092104351367000_74.5.439.16 doi: 10.1378/chest.13-1809 – ident: 2024092104351367000_74.5.439.26 doi: 10.1186/1465-9921-14-24 – ident: 2024092104351367000_74.5.439.54 doi: 10.1186/1465-9921-8-92 – volume: 7 start-page: 173 year: 2012 ident: 2024092104351367000_74.5.439.48 article-title: Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts publication-title: Int J Chron Obstruct Pulmon Dis |
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| Snippet | BackgroundConventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease.... Conventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying... |
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| SubjectTerms | Biomarkers - metabolism Chronic Obstructive Pulmonary Disease Clinical outcomes copd epidemiology Exercise Test Hemodynamics - physiology Humans Meta-analysis Mortality Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory Function Tests Severity of Illness Index Studies Systematic review Tumor necrosis factor-TNF |
| Title | Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis |
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