A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

Objectives Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases in animal models. The human NCF1 gene is very complex with both functional and non-functional gene copies and genotyping requires assays specific for functional N...

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Veröffentlicht in:	Annals of the rheumatic diseases Jg. 76; H. 9; S. 1607 - 1613
Hauptverfasser:	Olsson, Lina M, Johansson, Åsa C, Gullstrand, Birgitta, Jönsen, Andreas, Saevarsdottir, Saedis, Rönnblom, Lars, Leonard, Dag, Wetterö, Jonas, Sjöwall, Christopher, Svenungsson, Elisabet, Gunnarsson, Iva, Bengtsson, Anders A, Holmdahl, Rikard
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Limited 01.09.2017
Schlagworte:	Adult Alleles Animal models Autoimmune diseases autoimmunity Case-Control Studies Clinical Medicine Disease Female Gene Expression Gene Expression Regulation Gene polymorphism Genetic Predisposition to Disease Genomes Genotype & phenotype Genotyping Humans Inflammatory diseases Interferon Klinisk medicin Leukocytes (neutrophilic) Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Lymphocytes Male Medical and Health Sciences Medicin och hälsovetenskap Mutation NADPH oxidase complex NADPH Oxidases - genetics NCF1 Neutrophils Neutrophils - immunology Polymerase chain reaction Polymorphism, Single Nucleotide Reactive oxygen species Reactive Oxygen Species - metabolism Respiratory Burst - genetics Rheumatoid arthritis Rheumatology Single-nucleotide polymorphism SLE Studies Sweden Systemic lupus erythematosus White People - genetics Sweden NADPH oxidase complex NCF1 autoimmunity SLE reactive oxygen species
ISSN:	0003-4967, 1468-2060, 1468-2060
Online-Zugang:	Volltext
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