White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging
Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Background: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological a...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry Jg. 72; H. 6; S. 742 - 746 |
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| Hauptverfasser: | , , , , , , , |
| Format: | Journal Article Tagungsbericht |
| Sprache: | Englisch |
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London
BMJ Publishing Group Ltd
01.06.2002
BMJ BMJ Publishing Group LTD BMJ Group |
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| ISSN: | 0022-3050, 1468-330X |
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| Abstract | Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Background: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear. Methods: Conventional and DT-MRI scans were obtained from16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D̅), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured. Results: D̅ was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D̅ and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D̅ (r=0.92, p<0.001) and FA (r=0.78; p<0.001). Conclusions: White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas. |
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| AbstractList | Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Background: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear. Methods: Conventional and DT-MRI scans were obtained from16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D̅), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured. Results: D̅ was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D̅ and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D̅ (r=0.92, p<0.001) and FA (r=0.78; p<0.001). Conclusions: White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas. Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Background: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear. Methods: Conventional and DT-MRI scans were obtained from16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured. Results: was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter (r=0.92, p<0.001) and FA (r=0.78; p<0.001). Conclusions: White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas. Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Background: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear. Methods: Conventional and DT-MRI scans were obtained from16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D[...]), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured. Results: D[...] was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D[...] and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D[...] (r =0.92, p<0.001) and FA (r =0.78; p<0.001). Conclusions: White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas. To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear. Conventional and DT-MRI scans were obtained from 16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured. D was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D (r=0.92, p<0.001) and FA (r=0.78; p<0.001). White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas. To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI).OBJECTIVETo investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI).Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear.BACKGROUNDAlthough Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological and MRI studies showed that also the brain white matter of patients is damaged. However, the nature of Alzheimer's disease associated white matter damage is still unclear.Conventional and DT-MRI scans were obtained from 16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured.METHODSConventional and DT-MRI scans were obtained from 16 patients with Alzheimer's disease and 10 sex and age matched healthy volunteers. The mean diffusivity (D), fractional anisotropy (FA), and inter-voxel coherence (C) of several white matter regions were measured.D was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D (r=0.92, p<0.001) and FA (r=0.78; p<0.001).RESULTSD was higher and FA lower in the corpus callosum, as well as in the white matter of the frontal, temporal, and parietal lobes from patients with Alzheimer's disease than in the corresponding regions from healthy controls. D and FA of the white matter of the occipital lobe and internal capsule were not different between patients and controls. C values were also not different between patients and controls for any of the regions studied. Strong correlations were found between the mini mental state examination score and the average overall white matter D (r=0.92, p<0.001) and FA (r=0.78; p<0.001).White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas.CONCLUSIONSWhite matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas. |
| Audience | Professional Academic |
| Author | Comi, G Cercignani, M Bozzali, M Franceschi, M Scotti, G Zuffi, M Filippi, M Falini, A |
| AuthorAffiliation | Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy |
| AuthorAffiliation_xml | – name: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy |
| Author_xml | – sequence: 1 givenname: M surname: Bozzali fullname: Bozzali, M organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 2 givenname: A surname: Falini fullname: Falini, A organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 3 givenname: M surname: Franceschi fullname: Franceschi, M organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 4 givenname: M surname: Cercignani fullname: Cercignani, M organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 5 givenname: M surname: Zuffi fullname: Zuffi, M organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 6 givenname: G surname: Scotti fullname: Scotti, G organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 7 givenname: G surname: Comi fullname: Comi, G organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele – sequence: 8 givenname: M surname: Filippi fullname: Filippi, M organization: Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14170682$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12023417$$D View this record in MEDLINE/PubMed |
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| Keywords | Human Nervous system diseases Pathophysiology Alzheimer disease Nuclear magnetic resonance imaging White matter Cerebral disorder Central nervous system disease Medical imagery Degenerative disease Diffusion Microstructure Tensor method Brain (vertebrata) |
| Language | English |
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| Notes | PMID:12023417 Correspondence to: Dr M Filippi, Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy; m.filippi@hsr.it ark:/67375/NVC-8982N1W4-M local:0720742 href:jnnp-72-742.pdf istex:DE6DAC217720E08781C08106223CA72A2BC870FE ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| PublicationTitle | Journal of neurology, neurosurgery and psychiatry |
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| Snippet | Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic... To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging... |
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| SubjectTerms | Acquisitions & mergers Age Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - pathology Alzheimer's disease Anisotropy Attention deficit hyperactivity disorder Biological and medical sciences Brain Brain damage Cerebral Cortex - pathology Cognitive ability Corpus Callosum - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diffusion diffusion tensor magnetic resonance imaging DT-MRI Female fractional anisotropy Humans intervoxel coherence Magnetic resonance imaging Magnetic Resonance Imaging - methods Male mean diffusivity Medical sciences Middle Aged mini mental state examination MMSE Net losses Neurology NMR Nuclear magnetic resonance Pathology PGSE Physiological aspects pulsed gradient spin echo regions of interest ROIs Studies TSE turbo spin echo white matter damage |
| Title | White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging |
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