Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study

IntroductionIndividualised treatment through therapeutic drug monitoring (TDM) may improve tuberculosis (TB) treatment outcomes but is not routinely implemented. Prospective clinical studies of drug exposure and minimum inhibitory concentrations (MICs) in multidrug-resistant TB (MDR-TB) are scarce....

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Bibliographic Details
Published in:	BMJ open Vol. 8; no. 9; p. e023899
Main Authors:	Davies Forsman, Lina, Niward, Katarina, Hu, Yi, Zheng, Rongrong, Zheng, Xubin, Ke, Ran, Cai, Weiping, Hong, Chao, Li, Yang, Gao, Yazhou, Werngren, Jim, Paues, Jakob, Kuhlin, Johanna, Simonsson, Ulrika S H, Eliasson, Erik, Alffenaar, Jan-Willem, Mansjö, Mikael, Hoffner, Sven, Xu, Biao, Schön, Thomas, Bruchfeld, Judith
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 2018 BMJ Publishing Group
Subjects:	Adult Antibiotics Antitubercular Agents - administration & dosage Antitubercular Agents - classification Antitubercular Agents - pharmacokinetics China - epidemiology Clinical outcomes clinical pharmacology Cohort analysis Cohort Studies Drug dosages Drug Monitoring - methods Drug resistance Female Hospitals Humans Infectious Diseases Male Microbial Sensitivity Tests - methods microbiology Multidrug resistant organisms Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Observational studies Observational Studies as Topic Patients Pharmacokinetics Prospective Studies Public health Quality of life Serum Bactericidal Test Therapeutic drug monitoring Tuberculosis Tuberculosis, Multidrug-Resistant - blood Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology China microbiology clinical pharmacology public health tuberculosis
ISSN:	2044-6055, 2044-6055
Online Access:	Get full text
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