Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis
OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity (D̄) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from pa...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry Jg. 70; H. 3; S. 311 - 317 |
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| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
BMJ Publishing Group Ltd
01.03.2001
BMJ BMJ Publishing Group LTD BMJ Group |
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| ISSN: | 0022-3050, 1468-330X |
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| Abstract | OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity (D̄) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis. METHODS Dual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and D̄ were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis. RESULTS All the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the D̄histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of theD̄ histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls. CONCLUSIONS A technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM. |
|---|---|
| AbstractList | OBJECTIVE—To assess
the feasibility of a new technique based on diffusion anisotropy to
segment white and grey matter of the brain. To use this technique to
measure the mean diffusivity ( ) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis.
METHODS—Dual echo
turbo spin echo, MT, and diffusion weighted scans of the brain were
obtained from 30 patients with multiple sclerosis and 18 sex and age
matched healthy controls. After image coregistration and removal of T2
visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms
of the average MTR and were created for normal white and grey matter of controls and NAWM and NAGM of
patients with multiple sclerosis.
RESULTS—All the MTR
histogram derived metrics of the NAWM from patients with multiple
sclerosis were significantly lower than those of white matter from
controls. The peak height of the
histogram of NAWM from patients with multiple sclerosis was also
significantly different from that of normal white matter. The average
MTR, the peak location of the MTR histogram, and peak height of the
histogram of the NAGM of patients
with multiple sclerosis were significantly lower than the corresponding
quantities of grey matter from controls.
CONCLUSIONS—A
technique was developed for segmenting white and grey matter with the
potential for improving the understanding of the pathophysiology of
many neurological conditions. Its application to the study of multiple
sclerosis confirms the presence of a diffuse tissue damage in the NAWM
of these patients and suggests that subtle changes also occur in the NAGM. OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity (DÌ,, ) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis. METHODS Dual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and DÌ,, were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis. RESULTS All the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the DÌ,, histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of theDÌ,, histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls. CONCLUSIONS A technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM. To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity () and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis.OBJECTIVETo assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity () and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis.Dual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis.METHODSDual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis.All the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of the histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls.RESULTSAll the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of the histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls.A technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM.CONCLUSIONSA technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM. To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity () and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis. Dual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis. All the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of the histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls. A technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM. OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity (D̄) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis. METHODS Dual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and D̄ were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis. RESULTS All the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the D̄histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of theD̄ histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls. CONCLUSIONS A technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM. |
| Audience | Professional Academic |
| Author | Comi, G Cercignani, M Bozzali, M Filippi, M Iannucci, G |
| AuthorAffiliation | Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Via Olgettina 60, 20132 Milan, Italy |
| AuthorAffiliation_xml | – name: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Via Olgettina 60, 20132 Milan, Italy |
| Author_xml | – sequence: 1 givenname: M surname: Cercignani fullname: Cercignani, M email: filippi.massimo@hsr.it – sequence: 2 givenname: M surname: Bozzali fullname: Bozzali, M email: filippi.massimo@hsr.it – sequence: 3 givenname: G surname: Iannucci fullname: Iannucci, G email: filippi.massimo@hsr.it – sequence: 4 givenname: G surname: Comi fullname: Comi, G email: filippi.massimo@hsr.it – sequence: 5 givenname: M surname: Filippi fullname: Filippi, M email: filippi.massimo@hsr.it |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=933282$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11181851$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Journal of Neurology, Neurosurgery, and Psychiatry 2001 INIST-CNRS COPYRIGHT 2001 BMJ Publishing Group Ltd. Copyright: 2001 Journal of Neurology, Neurosurgery, and Psychiatry |
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| Snippet | OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to... To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the... OBJECTIVE—To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to... |
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| SubjectTerms | Adult Analysis Biological and medical sciences Brain - pathology Brain chemistry Development and progression Female grey matter diffusivity Humans Magnetic Resonance Imaging - methods magnetisation transfer ratio Male Medical sciences Middle Aged Multiple sclerosis Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Scanners white matter diffusity |
| Title | Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis |
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