Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

ObjectiveTo evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes.DesignWe present the results of a randomised, double-blinded, placebo-controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 75 patients alloc...

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Veröffentlicht in:	Rheumatic & musculoskeletal diseases open Jg. 7; H. 1; S. e001455
Hauptverfasser:	Lopes, Maria Isabel, Bonjorno, Leticia P, Giannini, Marcela C, Amaral, Natalia B, Menezes, Pamella Indira, Dib, Saulo Musse, Gigante, Samara Libich, Benatti, Maira N, Rezek, Uebe C, Emrich-Filho, Laerte L, Sousa, Betania A A, Almeida, Sergio C L, Luppino Assad, Rodrigo, Veras, Flavio P, Schneider, Ayda, Rodrigues, Tamara S, Leiria, Luiz O S, Cunha, Larissa D, Alves-Filho, Jose C, Cunha, Thiago M, Arruda, Eurico, Miranda, Carlos H, Pazin-Filho, Antonio, Auxiliadora-Martins, Maria, Borges, Marcos C, Fonseca, Benedito A L, Bollela, Valdes R, Del-Ben, Cristina M, Cunha, Fernando Q, Zamboni, Dario S, Santana, Rodrigo C, Vilar, Fernando C, Louzada-Junior, Paulo, Oliveira, Rene D R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England EULAR 01.02.2021 BMJ Publishing Group LTD BMJ Publishing Group
Schriftenreihe:	Original research
Schlagworte:	Adult Aged Cardiac arrhythmia Clinical trials Colchicine - administration & dosage Colchicine - adverse effects Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - mortality COVID-19 - virology cytokines Diarrhea - chemically induced Disease Double-Blind Method Drug dosages Dyspnea Female health care Humans Infections Inflammation Intensive Care Units Laboratories Length of Stay Male Middle Aged Neutrophils outcome assessment Oxygen Inhalation Therapy Patients Pneumonia Proteins Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Time Factors Treatment Outcome Tumor necrosis factor-TNF cytokines outcome assessment inflammation health care
ISSN:	2056-5933, 2056-5933
Online-Zugang:	Volltext
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