Incidence and prevalence of multiple sclerosis in the UK 1990–2010: a descriptive study in the General Practice Research Database

Objectives To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK. Design A descriptive...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry Vol. 85; no. 1; pp. 76 - 84
Main Authors: Mackenzie, I S, Morant, S V, Bloomfield, G A, MacDonald, T M, O'Riordan, J
Format: Journal Article
Language:English
Published: England BMJ Publishing Group LTD 01.01.2014
BMJ Publishing Group
Series:Research paper
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Databases, Factual
Disease
Female
Follow-Up Studies
General Practice - statistics & numerical data
Geography
Hospitalization - statistics & numerical data
Hospitals
Humans
Incidence
Longitudinal Studies
Male
Middle Aged
Mortality
Multiple Sclerosis
Multiple Sclerosis - epidemiology
Patients
Population
Practice research
Prevalence
Regression analysis
Sex Factors
Treatment Outcome
United Kingdom - epidemiology
Womens health
Young Adult
United Kingdom > UK
England
Wales
Multiple Sclerosis
Epidemiology
ISSN:0022-3050, 1468-330X, 1468-330X
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Abstract Objectives To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK. Design A descriptive study. Setting The study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population. Main outcome measures Incidence and prevalence of MS per 100 000 population. Secular and geographical trends in incidence and prevalence of MS. Results The prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100 000 in women (95% CI 278.7 to 293.1) and 113.1 per 100 000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100 000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK. Conclusions We estimate that 126 669 people were living with MS in the UK in 2010 (203.4 per 100 000 population) and that 6003 new cases were diagnosed that year (9.64 per 100 000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.
AbstractList To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK.OBJECTIVESTo estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK.A descriptive study.DESIGNA descriptive study.The study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population.SETTINGThe study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population.Incidence and prevalence of MS per 100 000 population. Secular and geographical trends in incidence and prevalence of MS.MAIN OUTCOME MEASURESIncidence and prevalence of MS per 100 000 population. Secular and geographical trends in incidence and prevalence of MS.The prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100 000 in women (95% CI 278.7 to 293.1) and 113.1 per 100 000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100 000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK.RESULTSThe prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100 000 in women (95% CI 278.7 to 293.1) and 113.1 per 100 000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100 000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK.We estimate that 126 669 people were living with MS in the UK in 2010 (203.4 per 100 000 population) and that 6003 new cases were diagnosed that year (9.64 per 100 000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.CONCLUSIONSWe estimate that 126 669 people were living with MS in the UK in 2010 (203.4 per 100 000 population) and that 6003 new cases were diagnosed that year (9.64 per 100 000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.
To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK. A descriptive study. The study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population. Incidence and prevalence of MS per 100 000 population. Secular and geographical trends in incidence and prevalence of MS. The prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100 000 in women (95% CI 278.7 to 293.1) and 113.1 per 100 000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100 000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK. We estimate that 126 669 people were living with MS in the UK in 2010 (203.4 per 100 000 population) and that 6003 new cases were diagnosed that year (9.64 per 100 000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.
ObjectivesTo estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK.DesignA descriptive study.SettingThe study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population.Main outcome measuresIncidence and prevalence of MS per 100000 population. Secular and geographical trends in incidence and prevalence of MS.ResultsThe prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100000 in women (95% CI 278.7 to 293.1) and 113.1 per 100000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50years and maximum prevalence between ages 55 and 60years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK.ConclusionsWe estimate that 126669 people were living with MS in the UK in 2010 (203.4 per 100000 population) and that 6003 new cases were diagnosed that year (9.64 per 100000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.
Objectives To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK. Design A descriptive study. Setting The study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population. Main outcome measures Incidence and prevalence of MS per 100 000 population. Secular and geographical trends in incidence and prevalence of MS. Results The prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100 000 in women (95% CI 278.7 to 293.1) and 113.1 per 100 000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100 000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK. Conclusions We estimate that 126 669 people were living with MS in the UK in 2010 (203.4 per 100 000 population) and that 6003 new cases were diagnosed that year (9.64 per 100 000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.
Author Bloomfield, G A
MacDonald, T M
Morant, S V
Mackenzie, I S
O'Riordan, J
AuthorAffiliation 3 Tayside Multiple Sclerosis Research Unit, Department of Neurology , Ninewells Hospital and Medical School , Dundee , UK
2 Multiple Sclerosis National Therapy Centres , Whitchurch , UK
1 Medicines Monitoring Unit (MEMO) , University of Dundee , Dundee , UK
AuthorAffiliation_xml – name: 3 Tayside Multiple Sclerosis Research Unit, Department of Neurology , Ninewells Hospital and Medical School , Dundee , UK
– name: 1 Medicines Monitoring Unit (MEMO) , University of Dundee , Dundee , UK
– name: 2 Multiple Sclerosis National Therapy Centres , Whitchurch , UK
Author_xml – sequence: 1
  givenname: I S
  surname: Mackenzie
  fullname: Mackenzie, I S
  email: i.s.mackenzie@dundee.ac.uk
  organization: Medicines Monitoring Unit (MEMO), University of Dundee, Dundee, UK
– sequence: 2
  givenname: S V
  surname: Morant
  fullname: Morant, S V
  email: i.s.mackenzie@dundee.ac.uk
  organization: Medicines Monitoring Unit (MEMO), University of Dundee, Dundee, UK
– sequence: 3
  givenname: G A
  surname: Bloomfield
  fullname: Bloomfield, G A
  email: i.s.mackenzie@dundee.ac.uk
  organization: Multiple Sclerosis National Therapy Centres, Whitchurch, UK
– sequence: 4
  givenname: T M
  surname: MacDonald
  fullname: MacDonald, T M
  email: i.s.mackenzie@dundee.ac.uk
  organization: Medicines Monitoring Unit (MEMO), University of Dundee, Dundee, UK
– sequence: 5
  givenname: J
  surname: O'Riordan
  fullname: O'Riordan, J
  email: i.s.mackenzie@dundee.ac.uk
  organization: Tayside Multiple Sclerosis Research Unit, Department of Neurology, Ninewells Hospital and Medical School, Dundee, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24052635$$D View this record in MEDLINE/PubMed
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Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2014
Copyright_xml – notice: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
– notice: Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
– notice: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2014
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Issue 1
Keywords Multiple Sclerosis
Epidemiology
Language English
License This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0
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Snippet Objectives To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over...
To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year...
ObjectivesTo estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over...
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SourceType Open Access Repository
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Index Database
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Publisher
StartPage 76
SubjectTerms Adult
Age
Age Factors
Aged
Aged, 80 and over
Databases, Factual
Disease
Female
Follow-Up Studies
General Practice - statistics & numerical data
Geography
Hospitalization - statistics & numerical data
Hospitals
Humans
Incidence
Longitudinal Studies
Male
Middle Aged
Mortality
Multiple Sclerosis
Multiple Sclerosis - epidemiology
Patients
Population
Practice research
Prevalence
Regression analysis
Sex Factors
Treatment Outcome
United Kingdom - epidemiology
Womens health
Young Adult
Title Incidence and prevalence of multiple sclerosis in the UK 1990–2010: a descriptive study in the General Practice Research Database
URI https://jnnp.bmj.com/content/85/1/76.full
https://www.ncbi.nlm.nih.gov/pubmed/24052635
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https://www.proquest.com/docview/1477556371
https://www.proquest.com/docview/1551614245
https://pubmed.ncbi.nlm.nih.gov/PMC3888639
Volume 85
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