ENSAT registry-based randomized clinical trials for adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been intro...
Saved in:
| Published in: | European journal of endocrinology Vol. 184; no. 2; p. R51 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
01.02.2021
|
| Subjects: | |
| ISSN: | 1479-683X, 1479-683X |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease. |
|---|---|
| AbstractList | Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease. Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease.Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease. |
| Author | Borson-Chazot, Françoise Crona, Joakim Ceccato, Filippo Aylwin, Simon Luconi, Michaela Bourdeau, Isabelle Paiva, Isabel Kroiss, Matthias Osher, Esthr De Martino, Maria Cristina Loli, Paula Mihai, Radu Arnaldi, Giorgio Quinkler, Marcus Bugalho, Maria João Feelders, Richard Sherlock, Mark Reimondo, Giuseppe Della Casa, Silvia Baudin, Eric Fassnacht, Martin Van Slycke, Sam Assié, Guillaume Beuschlein, Felix Tiberi, Guido A M Yiannakopoulou, Eugenia Bancos, Irina Rodien, Patrice Oliveira, Cristina Lamas Ettaieb, Hester Chrisoulidou, Alexandra Morelli, Valentina Nieveen van Dijkum, Els J M de Krijger, Ronald Berruti, Alfredo Ronchi, Cristina L Trofimiuk-Müldner, Małgorzata Nowak, Karolina M Dennedy, Michael Conall Terzolo, Massimo Igaz, Peter Angelousi, Anna Naruse, Mitsuhide Newell-Price, John Kiriakopoulos, Andreas Shafigullina, Zulfiya Kastelan, Darko Romero, M Tous Vantyghem, Marie-Christine Canu, Letizia Vroonen, Laurent |
| Author_xml | – sequence: 1 givenname: Joakim surname: Crona fullname: Crona, Joakim organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden – sequence: 2 givenname: Eric surname: Baudin fullname: Baudin, Eric organization: Gustave Roussy, Université Paris-Saclay, Département d'imagerie, Service d'oncologie endocrinienne, Villejuif, France – sequence: 3 givenname: Massimo surname: Terzolo fullname: Terzolo, Massimo organization: Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Italy – sequence: 4 givenname: Alexandra surname: Chrisoulidou fullname: Chrisoulidou, Alexandra organization: Department of Endocrinology, Theagenio Cancer Hospital, Thessaloniki, Greece – sequence: 5 givenname: Anna surname: Angelousi fullname: Angelousi, Anna organization: 1st Department of Internal Medicine, Unit of Endocrinology, National and Kapodistrian University of Athens, Laiko Hospital, Athens, Greece – sequence: 6 givenname: Cristina L surname: Ronchi fullname: Ronchi, Cristina L organization: Division of Endocrinology and Diabetes, University Hospital of Würzburg, Würzburg, Germany – sequence: 7 givenname: Cristina Lamas surname: Oliveira fullname: Oliveira, Cristina Lamas organization: Endocrinology Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain – sequence: 8 givenname: Els J M surname: Nieveen van Dijkum fullname: Nieveen van Dijkum, Els J M organization: Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands – sequence: 9 givenname: Filippo surname: Ceccato fullname: Ceccato, Filippo organization: Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy – sequence: 10 givenname: Françoise surname: Borson-Chazot fullname: Borson-Chazot, Françoise organization: Hospices Civils de Lyon, Fédération d'Endocrinologie, Université Claude Bernard Lyon 1, Lyon, France – sequence: 11 givenname: Giuseppe surname: Reimondo fullname: Reimondo, Giuseppe organization: Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy – sequence: 12 givenname: Guido A M surname: Tiberi fullname: Tiberi, Guido A M organization: Surgical Clinic, Department of Clinical and Experimental Sciences, University of Brescia at ASST Spedali Civili, Brescia, Italy – sequence: 13 givenname: Hester surname: Ettaieb fullname: Ettaieb, Hester organization: Division of Endocrinology, Department of Internal Medicine, Maxima Medical Center, Eindhoven/Veldhoven, The Netherlands – sequence: 14 givenname: Andreas surname: Kiriakopoulos fullname: Kiriakopoulos, Andreas organization: 5th Surgical Clinic, 'Evgenidion Hospital' National and Kapodistrian University of Athens School of Medicine, Athens, Greece – sequence: 15 givenname: Letizia surname: Canu fullname: Canu, Letizia organization: Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy – sequence: 16 givenname: Darko surname: Kastelan fullname: Kastelan, Darko organization: Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia – sequence: 17 givenname: Esthr surname: Osher fullname: Osher, Esthr organization: Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel – sequence: 18 givenname: Eugenia surname: Yiannakopoulou fullname: Yiannakopoulou, Eugenia organization: Department of Biomedical Sciences, Faculty of Health Sciences, University of West Attica, Athens, Greece – sequence: 19 givenname: Giorgio surname: Arnaldi fullname: Arnaldi, Giorgio organization: Division of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy – sequence: 20 givenname: Guillaume surname: Assié fullname: Assié, Guillaume organization: Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France – sequence: 21 givenname: Isabel surname: Paiva fullname: Paiva, Isabel organization: Department os Endocrinology, Diabetes and Metabolism, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal – sequence: 22 givenname: Isabelle surname: Bourdeau fullname: Bourdeau, Isabelle organization: Division of Endocrinology, Department of Medicine, Research Center, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Québec, Canada – sequence: 23 givenname: John surname: Newell-Price fullname: Newell-Price, John organization: Department of Oncology and Metabolism, The Medical School University of Sheffield, Sheffield, UK – sequence: 24 givenname: Karolina M surname: Nowak fullname: Nowak, Karolina M organization: Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, Warsaw, Poland – sequence: 25 givenname: M Tous surname: Romero fullname: Romero, M Tous organization: UGC Endocrinología y Nutrición, Hospital Universitario Virgen Macarena, Seville, Spain – sequence: 26 givenname: Maria Cristina surname: De Martino fullname: De Martino, Maria Cristina organization: Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy – sequence: 27 givenname: Maria João surname: Bugalho fullname: Bugalho, Maria João organization: Serviço de Endocrinologia, Diabetes e Metabolismo, CHULN and Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal – sequence: 28 givenname: Mark surname: Sherlock fullname: Sherlock, Mark organization: Department of Endocrinology, Beaumont Hospital and the Royal College of Surgeons in Ireland, Dublin, Ireland – sequence: 29 givenname: Marie-Christine surname: Vantyghem fullname: Vantyghem, Marie-Christine organization: Endocrinology, Diabetology, Metabolism and Nutrition Department, Lille University Hospital, Lille, France – sequence: 30 givenname: Michael Conall surname: Dennedy fullname: Dennedy, Michael Conall organization: Department of Endocrinology & Diabetes Mellitus, c/o Department of Medicine, Clinical Sciences Institute, National University of Ireland, Galway, Galway, Ireland – sequence: 31 givenname: Paula surname: Loli fullname: Loli, Paula organization: Ospedale Niguarda Ca' Granda, Endocrinology, Napoli, Italy – sequence: 32 givenname: Patrice surname: Rodien fullname: Rodien, Patrice organization: Service d'Endocrinologie Diabétologie et Nutrition, CHU d'Angers, Angers Cedex 9, France – sequence: 33 givenname: Richard surname: Feelders fullname: Feelders, Richard organization: Erasmus Medical Center, Division of Endocrinology, Department of Internal Medicine, Rotterdam, The Netherlands – sequence: 34 givenname: Ronald surname: de Krijger fullname: de Krijger, Ronald organization: Department of Pathology, University Medical Center, Utrecht, The Netherlands – sequence: 35 givenname: Sam surname: Van Slycke fullname: Van Slycke, Sam organization: General and Endocrine Surgery, OLV Hospital Aalst, Aalst, Belgium – sequence: 36 givenname: Simon surname: Aylwin fullname: Aylwin, Simon organization: King's College Hospital, London, UK – sequence: 37 givenname: Valentina surname: Morelli fullname: Morelli, Valentina organization: Endocrinology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy – sequence: 38 givenname: Laurent surname: Vroonen fullname: Vroonen, Laurent organization: Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Liege, Belgium – sequence: 39 givenname: Zulfiya surname: Shafigullina fullname: Shafigullina, Zulfiya organization: Endocrinology Department, North-Western Medical University named after I.I.Mechnikov, Saint-Petersburg, Russia – sequence: 40 givenname: Irina surname: Bancos fullname: Bancos, Irina organization: Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA – sequence: 41 givenname: Małgorzata surname: Trofimiuk-Müldner fullname: Trofimiuk-Müldner, Małgorzata organization: Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland – sequence: 42 givenname: Marcus surname: Quinkler fullname: Quinkler, Marcus organization: Endocrinology in Charlottenburg, Berlin, Germany – sequence: 43 givenname: Michaela surname: Luconi fullname: Luconi, Michaela organization: Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy – sequence: 44 givenname: Matthias surname: Kroiss fullname: Kroiss, Matthias organization: Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany – sequence: 45 givenname: Mitsuhide surname: Naruse fullname: Naruse, Mitsuhide organization: Endocrine Center, Ijinkai Takeda General Hospital and Clinical Research Institute of Endocrinology and Metabolism, NHO Kyoto Medical Center, Kyoto, Japan – sequence: 46 givenname: Peter surname: Igaz fullname: Igaz, Peter organization: MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary – sequence: 47 givenname: Radu surname: Mihai fullname: Mihai, Radu organization: Churchill Cancer Centre, Department of Endocrine Surgery, Oxford University, Oxford, UK – sequence: 48 givenname: Silvia surname: Della Casa fullname: Della Casa, Silvia organization: Endocrinology Department, Gemelli Polyclinic Foundation, Catholic University, Rome, Italy – sequence: 49 givenname: Alfredo surname: Berruti fullname: Berruti, Alfredo organization: Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology, University of Brescia at ASST Spedali Civili, Brescia, Italy – sequence: 50 givenname: Martin surname: Fassnacht fullname: Fassnacht, Martin organization: Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany – sequence: 51 givenname: Felix surname: Beuschlein fullname: Beuschlein, Felix organization: Department of Endocrinology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33166271$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkDtPwzAAhC1URB8wsaOMLAY_YjseqyrloQoGisQW-YmMkrjY6VB-PREUieXupPt0w83BpI-9A-ASoxvMKLqtH2tIEEQVQidghkshIa_o2-RfnoJ5zh8IYV5SdAamlGLOicAzsKmfXpbbIrn3kId0gFplZ4ukehu78DVG04Y-GNUWQwqqzYWPqVA2uT6amIafxqhkQh87dQ5O_ci4i6MvwOu63q7u4eb57mG13EDNmBwgUYyIykpiGZdOcm8F0dh5LwUtlRAOW06dwFpVpjSO6dJrT4wVzFgzClmA69_dXYqfe5eHpgvZuLZVvYv73JCSScpYheSIXh3Rve6cbXYpdCodmr8HyDcLBV-M |
| CitedBy_id | crossref_primary_10_48095_cccu2025012 crossref_primary_10_1055_a_1453_0806 crossref_primary_10_3390_cancers14163904 crossref_primary_10_1007_s00066_021_01838_6 crossref_primary_10_1016_j_ctro_2022_05_003 crossref_primary_10_3390_biomedicines9020174 crossref_primary_10_1186_s13063_023_07109_2 crossref_primary_10_1016_j_ejso_2023_03_001 crossref_primary_10_1016_j_arcmed_2022_12_003 crossref_primary_10_3390_cancers13215266 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1530/EJE-20-0800 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1479-683X |
| ExternalDocumentID | 33166271 |
| Genre | Journal Article Review |
| GeographicLocations | Europe |
| GeographicLocations_xml | – name: Europe |
| GroupedDBID | --- -~X .55 .GJ 0R~ 18M 2WC 3O- 4.4 53G 5GY 5RE 5VS 5WD AABZA AACZT AAPGJ AAPXW AARHZ AAUAY AAVAP AAWDT ABDFA ABEJV ABGNP ABIME ABJNI ABMNT ABNHQ ABOCM ABPIB ABPQP ABPTD ABQNK ABSQV ABVGC ABWST ABXVV ABXZS ACFRR ACGFO ACNCT ACPRK ACUTJ ADBBV ADGKP ADIPN ADMTO ADNBA ADQBN ADVEK ADVOB AEMQT AENEX AFFNX AFGWE AFHIN AFXAL AFYAG AGQXC AGUTN AHMMS AI. AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALXQX ANFBD APJGH ATGXG BAWUL BCRHZ BTFSW C1A CGR CS3 CUY CVF DU5 E3Z EBS ECM EIF EJD EMOBN F9R GX1 H13 HZ~ IL9 INIJC J5H KOP KQ8 L7B NPM O9- OAUYM OBFPC OBOKY OCZFY OJZSN OK1 OPAEJ OVD OWPYF P2P ROX SJN TBS TCN TEORI TMA TR2 VH1 W8F WOQ X7M ZGI ZXP 7X8 AJBYB NU- |
| ID | FETCH-LOGICAL-b559t-2a5278d92d569e96fd72b1eff9734a77e1d63e71ba8c4ce5b4fbf2cd75cdc75c2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 11 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000608421100006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1479-683X |
| IngestDate | Wed Oct 01 13:54:13 EDT 2025 Thu Apr 03 07:04:15 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b559t-2a5278d92d569e96fd72b1eff9734a77e1d63e71ba8c4ce5b4fbf2cd75cdc75c2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://eje.bioscientifica.com/downloadpdf/journals/eje/184/2/EJE-20-0800.pdf |
| PMID | 33166271 |
| PQID | 2459355809 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2459355809 pubmed_primary_33166271 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-02-01 |
| PublicationDateYYYYMMDD | 2021-02-01 |
| PublicationDate_xml | – month: 02 year: 2021 text: 2021-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | European journal of endocrinology |
| PublicationTitleAlternate | Eur J Endocrinol |
| PublicationYear | 2021 |
| SSID | ssj0016430 |
| Score | 2.3992784 |
| SecondaryResourceType | review_article |
| Snippet | Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | R51 |
| SubjectTerms | Adrenal Cortex Neoplasms - diagnosis Adrenal Cortex Neoplasms - epidemiology Adrenal Cortex Neoplasms - therapy Adrenocortical Carcinoma - diagnosis Adrenocortical Carcinoma - epidemiology Adrenocortical Carcinoma - therapy Endocrinology - organization & administration Endocrinology - standards Europe Evidence-Based Medicine - organization & administration Evidence-Based Medicine - standards Evidence-Based Medicine - trends Humans Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - standards Randomized Controlled Trials as Topic - statistics & numerical data Registries Social Networking |
| Title | ENSAT registry-based randomized clinical trials for adrenocortical carcinoma |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33166271 https://www.proquest.com/docview/2459355809 |
| Volume | 184 |
| WOSCitedRecordID | wos000608421100006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LS8MwGA_qRLz42HzMFxHEW3BN2qY5yZAOka0MnNJbyRN2WDvtFPSvN8k6dhIELyGXQPnyNd_ve_4AuGHYEGIihQwVDIVUCMRV7IoAOOWKRibxXASvQ5plSZ6zcRNwq5uyytWb6B9qVUkXI7_DYeRHgffY_fwNOdYol11tKDQ2QYtYKON-TJqvswjW2vqGyJAyFCckb_rzItK7S59SqyDI4aXfsaW3MYP9_37dAdhr0CXsL9XhEGzosg06_dJ61rMveAt9vacPpLfBzqhJq3fAMM2e-xPoSBoc9xtypk1Ba8VUNZt-2-2qfxJ6ko8aWqQLuesBr6zz6qPhUDpSorKa8SPwMkgnD4-ooVlAwroTC4R5hGmiGFZRzDSLjaJYBNoYRknIKdWBiommgeCJDKWORGiEwdJepFTSLvgYbJVVqU8B7AkiLR4x3PmdmoskCGSsJZeax5wmcRdcr8RXWDV2uQle6uqjLtYC7IKT5R0U8-W8jYKQwI2pD87-cPoc7GJXdeLrqi9Ay1ih6EuwLT8X0_r9yuuHXbPx6Ae96sbd |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ENSAT+registry-based+randomized+clinical+trials+for+adrenocortical+carcinoma&rft.jtitle=European+journal+of+endocrinology&rft.au=Crona%2C+Joakim&rft.au=Baudin%2C+Eric&rft.au=Terzolo%2C+Massimo&rft.au=Chrisoulidou%2C+Alexandra&rft.date=2021-02-01&rft.eissn=1479-683X&rft.volume=184&rft.issue=2&rft.spage=R51&rft_id=info:doi/10.1530%2FEJE-20-0800&rft_id=info%3Apmid%2F33166271&rft_id=info%3Apmid%2F33166271&rft.externalDocID=33166271 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1479-683X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1479-683X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1479-683X&client=summon |