ENSAT registry-based randomized clinical trials for adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been intro...

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Veröffentlicht in:	European journal of endocrinology Jg. 184; H. 2; S. R51
Hauptverfasser:	Crona, Joakim, Baudin, Eric, Terzolo, Massimo, Chrisoulidou, Alexandra, Angelousi, Anna, Ronchi, Cristina L, Oliveira, Cristina Lamas, Nieveen van Dijkum, Els J M, Ceccato, Filippo, Borson-Chazot, Françoise, Reimondo, Giuseppe, Tiberi, Guido A M, Ettaieb, Hester, Kiriakopoulos, Andreas, Canu, Letizia, Kastelan, Darko, Osher, Esthr, Yiannakopoulou, Eugenia, Arnaldi, Giorgio, Assié, Guillaume, Paiva, Isabel, Bourdeau, Isabelle, Newell-Price, John, Nowak, Karolina M, Romero, M Tous, De Martino, Maria Cristina, Bugalho, Maria João, Sherlock, Mark, Vantyghem, Marie-Christine, Dennedy, Michael Conall, Loli, Paula, Rodien, Patrice, Feelders, Richard, de Krijger, Ronald, Van Slycke, Sam, Aylwin, Simon, Morelli, Valentina, Vroonen, Laurent, Shafigullina, Zulfiya, Bancos, Irina, Trofimiuk-Müldner, Małgorzata, Quinkler, Marcus, Luconi, Michaela, Kroiss, Matthias, Naruse, Mitsuhide, Igaz, Peter, Mihai, Radu, Della Casa, Silvia, Berruti, Alfredo, Fassnacht, Martin, Beuschlein, Felix
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.02.2021
Schlagworte:	Adrenal Cortex Neoplasms - diagnosis Adrenal Cortex Neoplasms - epidemiology Adrenal Cortex Neoplasms - therapy Adrenocortical Carcinoma - diagnosis Adrenocortical Carcinoma - epidemiology Adrenocortical Carcinoma - therapy Endocrinology - organization & administration Endocrinology - standards Europe Evidence-Based Medicine - organization & administration Evidence-Based Medicine - standards Evidence-Based Medicine - trends Humans Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - standards Randomized Controlled Trials as Topic - statistics & numerical data Registries Social Networking Europe
ISSN:	1479-683X, 1479-683X
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Zusammenfassung:	Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1479-683X 1479-683X
DOI:	10.1530/EJE-20-0800