Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial)

IntroductionPostoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological ad...

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Bibliographic Details
Published in:	BMJ open Vol. 11; no. 12; p. e054681
Main Authors:	Wang, Hong, Duan, Chong-Yang, Huang, Wen-Qi, Zhao, Ping, Zhou, Li-Zhi, Liu, Yan-Hong, Liu, Cun-Ming, Chu, Hai-Chen, Wang, Qiang, Diao, Yu-Gang, Hua, Zhen, Meng, Qing-Tao, Li, Hao, Zhang, Xiao-Ying, Mi, Wei-Dong, Chen, Ping-Yan
Format:	Journal Article
Language:	English
Published:	England British Medical Journal Publishing Group 16.12.2021 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Protocol
Subjects:	acute postoperative pain Adult Anaesthesia Analgesics Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Angina pectoris Benzodiazepines Blood pressure Clinical medicine Clinical trials Cognitive ability Consciousness Delirium Drug dosages esketamine General anesthesia Humans Informed consent Ketamine Ketamine - therapeutic use Medical personnel Multicenter Studies as Topic multimodal analgesia Narcotics Orthopedics Pain Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - etiology Patients Postoperative period pragmatic clinical trial Randomized Controlled Trials as Topic S(+)-ketamine Thoracic surgery China acute postoperative pain S(+)-ketamine multimodal analgesia esketamine pragmatic clinical trial
ISSN:	2044-6055, 2044-6055
Online Access:	Get full text
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