Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial)

IntroductionPostoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological ad...

Full description

Saved in:

Bibliographic Details
Published in:	BMJ open Vol. 11; no. 12; p. e054681
Main Authors:	Wang, Hong, Duan, Chong-Yang, Huang, Wen-Qi, Zhao, Ping, Zhou, Li-Zhi, Liu, Yan-Hong, Liu, Cun-Ming, Chu, Hai-Chen, Wang, Qiang, Diao, Yu-Gang, Hua, Zhen, Meng, Qing-Tao, Li, Hao, Zhang, Xiao-Ying, Mi, Wei-Dong, Chen, Ping-Yan
Format:	Journal Article
Language:	English
Published:	England British Medical Journal Publishing Group 16.12.2021 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Protocol
Subjects:	acute postoperative pain Adult Anaesthesia Analgesics Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Angina pectoris Benzodiazepines Blood pressure Clinical medicine Clinical trials Cognitive ability Consciousness Delirium Drug dosages esketamine General anesthesia Humans Informed consent Ketamine Ketamine - therapeutic use Medical personnel Multicenter Studies as Topic multimodal analgesia Narcotics Orthopedics Pain Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - etiology Patients Postoperative period pragmatic clinical trial Randomized Controlled Trials as Topic S(+)-ketamine Thoracic surgery China acute postoperative pain S(+)-ketamine multimodal analgesia esketamine pragmatic clinical trial
ISSN:	2044-6055, 2044-6055
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	IntroductionPostoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) is designed to investigate the analgesic effect and safety of S(+)-ketamine for acute postoperative pain in adults and explore the optimal strategy of perioperative intravenous S(+)-ketamine in a real-world setting.Methods and analysisThis multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A study) is planned to conduct in 80 centres from China and recruit a total of 12 000 adult participants undergoing a surgical procedure under general anaesthesia. Patient recruitment started in June 2021 and will end in June 2022. Participants will be randomised in a ratio of 2:1 to either receive perioperative intravenous S(+)-ketamine plus conventional anaesthesia or conventional anaesthesia only. Given the pragmatic nature of the study, no specific restriction as to the administration dosage, route, time, synergistic regimen or basic analgesics. Primary endpoints are the area under the broken line of Numerical Rating Scale (NRS) scores for pain intensity and the total opioid consumption within 48 hours postoperative. Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes. The general linear model will be used for the primary endpoint, and appropriate methods will be used for the secondary endpoints.Ethics and disseminationThis trial has been approved by the local Institutional Review Board (S2021-026-02) and conducted following the Declaration of Helsinki. Results of this trial will be publicly disclosed and published in scientific journals.Trial registration numberNCT04837170; Pre-results.
AbstractList	Postoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) is designed to investigate the analgesic effect and safety of S(+)-ketamine for acute postoperative pain in adults and explore the optimal strategy of perioperative intravenous S(+)-ketamine in a real-world setting. This multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A study) is planned to conduct in 80 centres from China and recruit a total of 12 000 adult participants undergoing a surgical procedure under general anaesthesia. Patient recruitment started in June 2021 and will end in June 2022. Participants will be randomised in a ratio of 2:1 to either receive perioperative intravenous S(+)-ketamine plus conventional anaesthesia or conventional anaesthesia only. Given the pragmatic nature of the study, no specific restriction as to the administration dosage, route, time, synergistic regimen or basic analgesics. Primary endpoints are the area under the broken line of Numerical Rating Scale (NRS) scores for pain intensity and the total opioid consumption within 48 hours postoperative. Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes. The general linear model will be used for the primary endpoint, and appropriate methods will be used for the secondary endpoints. This trial has been approved by the local Institutional Review Board (S2021-026-02) and conducted following the Declaration of Helsinki. Results of this trial will be publicly disclosed and published in scientific journals. NCT04837170; Pre-results. Postoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) is designed to investigate the analgesic effect and safety of S(+)-ketamine for acute postoperative pain in adults and explore the optimal strategy of perioperative intravenous S(+)-ketamine in a real-world setting.INTRODUCTIONPostoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) is designed to investigate the analgesic effect and safety of S(+)-ketamine for acute postoperative pain in adults and explore the optimal strategy of perioperative intravenous S(+)-ketamine in a real-world setting.This multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A study) is planned to conduct in 80 centres from China and recruit a total of 12 000 adult participants undergoing a surgical procedure under general anaesthesia. Patient recruitment started in June 2021 and will end in June 2022. Participants will be randomised in a ratio of 2:1 to either receive perioperative intravenous S(+)-ketamine plus conventional anaesthesia or conventional anaesthesia only. Given the pragmatic nature of the study, no specific restriction as to the administration dosage, route, time, synergistic regimen or basic analgesics. Primary endpoints are the area under the broken line of Numerical Rating Scale (NRS) scores for pain intensity and the total opioid consumption within 48 hours postoperative. Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes. The general linear model will be used for the primary endpoint, and appropriate methods will be used for the secondary endpoints.METHODS AND ANALYSISThis multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A study) is planned to conduct in 80 centres from China and recruit a total of 12 000 adult participants undergoing a surgical procedure under general anaesthesia. Patient recruitment started in June 2021 and will end in June 2022. Participants will be randomised in a ratio of 2:1 to either receive perioperative intravenous S(+)-ketamine plus conventional anaesthesia or conventional anaesthesia only. Given the pragmatic nature of the study, no specific restriction as to the administration dosage, route, time, synergistic regimen or basic analgesics. Primary endpoints are the area under the broken line of Numerical Rating Scale (NRS) scores for pain intensity and the total opioid consumption within 48 hours postoperative. Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes. The general linear model will be used for the primary endpoint, and appropriate methods will be used for the secondary endpoints.This trial has been approved by the local Institutional Review Board (S2021-026-02) and conducted following the Declaration of Helsinki. Results of this trial will be publicly disclosed and published in scientific journals.ETHICS AND DISSEMINATIONThis trial has been approved by the local Institutional Review Board (S2021-026-02) and conducted following the Declaration of Helsinki. Results of this trial will be publicly disclosed and published in scientific journals.NCT04837170; Pre-results.TRIAL REGISTRATION NUMBERNCT04837170; Pre-results. IntroductionPostoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) is designed to investigate the analgesic effect and safety of S(+)-ketamine for acute postoperative pain in adults and explore the optimal strategy of perioperative intravenous S(+)-ketamine in a real-world setting.Methods and analysisThis multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A study) is planned to conduct in 80 centres from China and recruit a total of 12 000 adult participants undergoing a surgical procedure under general anaesthesia. Patient recruitment started in June 2021 and will end in June 2022. Participants will be randomised in a ratio of 2:1 to either receive perioperative intravenous S(+)-ketamine plus conventional anaesthesia or conventional anaesthesia only. Given the pragmatic nature of the study, no specific restriction as to the administration dosage, route, time, synergistic regimen or basic analgesics. Primary endpoints are the area under the broken line of Numerical Rating Scale (NRS) scores for pain intensity and the total opioid consumption within 48 hours postoperative. Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes. The general linear model will be used for the primary endpoint, and appropriate methods will be used for the secondary endpoints.Ethics and disseminationThis trial has been approved by the local Institutional Review Board (S2021-026-02) and conducted following the Declaration of Helsinki. Results of this trial will be publicly disclosed and published in scientific journals.Trial registration numberNCT04837170; Pre-results. Introduction Postoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine is appealing as an adjuvant drug in multimodal analgesia due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) is designed to investigate the analgesic effect and safety of S(+)-ketamine for acute postoperative pain in adults and explore the optimal strategy of perioperative intravenous S(+)-ketamine in a real-world setting.Methods and analysis This multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A study) is planned to conduct in 80 centres from China and recruit a total of 12 000 adult participants undergoing a surgical procedure under general anaesthesia. Patient recruitment started in June 2021 and will end in June 2022. Participants will be randomised in a ratio of 2:1 to either receive perioperative intravenous S(+)-ketamine plus conventional anaesthesia or conventional anaesthesia only. Given the pragmatic nature of the study, no specific restriction as to the administration dosage, route, time, synergistic regimen or basic analgesics. Primary endpoints are the area under the broken line of Numerical Rating Scale (NRS) scores for pain intensity and the total opioid consumption within 48 hours postoperative. Secondary endpoints are postoperative NRS scores, the anaesthesia recovery time, time of first rescue analgesia, the incidence of rescue analgesia, the incidence of postoperative delirium, patient questionnaire for effect, changes from baseline in cognitive function and anxiety and depression, as well as the adverse events and pharmacoeconomic outcomes. The general linear model will be used for the primary endpoint, and appropriate methods will be used for the secondary endpoints.Ethics and dissemination This trial has been approved by the local Institutional Review Board (S2021-026-02) and conducted following the Declaration of Helsinki. Results of this trial will be publicly disclosed and published in scientific journals.Trial registration number NCT04837170; Pre-results.
Author	Zhao, Ping Liu, Cun-Ming Duan, Chong-Yang Li, Hao Wang, Qiang Mi, Wei-Dong Chu, Hai-Chen Zhang, Xiao-Ying Wang, Hong Zhou, Li-Zhi Hua, Zhen Huang, Wen-Qi Meng, Qing-Tao Chen, Ping-Yan Diao, Yu-Gang Liu, Yan-Hong
AuthorAffiliation	4 Department of Anesthesiology , Shengjing Hospital of China Medical University , Shenyang , Liaoning , China 6 Department of Anesthesiology , The Affiliated Hospital of Qingdao University , Qingdao , Shandong , China 7 Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , China 1 Department of Anesthesiology , The First Medical Center of Chinese PLA General Hospital , Beijing , China 9 Department of Anesthesiology , Beijing Hospital , Beijing , China 2 Department of Biostatistics , School of Public Health, Southern Medical University , Guangzhou , Guangdong , China 3 Department of Anesthesiology , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , Guangdong , China 10 Department of Anesthesiology , Renmin Hospital of Wuhan University , Wuhan , Hubei , China 8 Department of Anesthesiology , General Hospital of Northern Theater Command , Shenyang , Liaoning , China 5 Department of Anesthesiology , Jiangsu Province Hospita
AuthorAffiliation_xml	– name: 10 Department of Anesthesiology , Renmin Hospital of Wuhan University , Wuhan , Hubei , China – name: 9 Department of Anesthesiology , Beijing Hospital , Beijing , China – name: 3 Department of Anesthesiology , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , Guangdong , China – name: 5 Department of Anesthesiology , Jiangsu Province Hospital , Nanjing , Jiangsu , China – name: 7 Department of Anesthesiology , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , China – name: 8 Department of Anesthesiology , General Hospital of Northern Theater Command , Shenyang , Liaoning , China – name: 4 Department of Anesthesiology , Shengjing Hospital of China Medical University , Shenyang , Liaoning , China – name: 1 Department of Anesthesiology , The First Medical Center of Chinese PLA General Hospital , Beijing , China – name: 2 Department of Biostatistics , School of Public Health, Southern Medical University , Guangzhou , Guangdong , China – name: 6 Department of Anesthesiology , The Affiliated Hospital of Qingdao University , Qingdao , Shandong , China
Author_xml	– sequence: 1 givenname: Hong orcidid: 0000-0002-5348-362X surname: Wang fullname: Wang, Hong organization: Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China – sequence: 2 givenname: Chong-Yang surname: Duan fullname: Duan, Chong-Yang organization: Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China – sequence: 3 givenname: Wen-Qi surname: Huang fullname: Huang, Wen-Qi organization: Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China – sequence: 4 givenname: Ping surname: Zhao fullname: Zhao, Ping organization: Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China – sequence: 5 givenname: Li-Zhi surname: Zhou fullname: Zhou, Li-Zhi organization: Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China – sequence: 6 givenname: Yan-Hong surname: Liu fullname: Liu, Yan-Hong organization: Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China – sequence: 7 givenname: Cun-Ming surname: Liu fullname: Liu, Cun-Ming organization: Department of Anesthesiology, Jiangsu Province Hospital, Nanjing, Jiangsu, China – sequence: 8 givenname: Hai-Chen surname: Chu fullname: Chu, Hai-Chen organization: Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China – sequence: 9 givenname: Qiang surname: Wang fullname: Wang, Qiang organization: Department of Anesthesiology, The First Affiliated Hospital of Xi"an Jiaotong University, Xi"an, Shaanxi, China – sequence: 10 givenname: Yu-Gang surname: Diao fullname: Diao, Yu-Gang organization: Department of Anesthesiology, General Hospital of Northern Theater Command, Shenyang, Liaoning, China – sequence: 11 givenname: Zhen surname: Hua fullname: Hua, Zhen organization: Department of Anesthesiology, Beijing Hospital, Beijing, China – sequence: 12 givenname: Qing-Tao surname: Meng fullname: Meng, Qing-Tao organization: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China – sequence: 13 givenname: Hao surname: Li fullname: Li, Hao organization: Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China – sequence: 14 givenname: Xiao-Ying surname: Zhang fullname: Zhang, Xiao-Ying organization: Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China – sequence: 15 givenname: Wei-Dong orcidid: 0000-0001-9814-2450 surname: Mi fullname: Mi, Wei-Dong email: wwdd1962@aliyun.com organization: Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China – sequence: 16 givenname: Ping-Yan surname: Chen fullname: Chen, Ping-Yan email: chenpy99@126.com organization: Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34916327$$D View this record in MEDLINE/PubMed
BookMark	eNp9kl1r1UAQhoNUbK39BYIseHOKjd2P7J7EC-FQWi0WFKrXy2QzqXvcZNNNUuhP9F-5OTm1HxcNJBtm3vfJZGZeJzutbzFJ3jL6kTGhjstm7TtsU045S6nMVM5eJHucZlmqqJQ7D953k4O-X9N4ZbKQkr9KdkVWMCX4ci_5-wODjaQAg71BYtshwA22fuzJ5eLDYfoHB2hsi6T2gYAZBySd74d7Rwe2jTYC1eiG_hPph7G6JV3wgzfezTbSxJw1GOF4RAK0lW9sj9UR2fyDgxLd0cS1EzI1Pgq9c5OgC3DVxC8ZYpxtrQFHhmDjc3G5OjtNL7-lqzlw-CZ5WYPr8WB77ie_zk5_nnxNL75_OT9ZXaSlFMWQmqJgkFdUlbWiZcWRFVDkXEnDFRcMGNQSgEvBgXMqBKKsljGiZF5ghlTsJ-czt_Kw1l2wDYRb7cHqTcCHKw0hFuxQ07ysKyyZFBQzg1WZ18tKKmUUZkxAHVmfZ1Y3lg1Wmw6BewR9nGntb33lb3SulgUTMgIWW0Dw1yP2g46NNegctBhnqLliTElFcxal759I134MbWzVpKJLHu88qt49rOh_KXcbEwXFLDDB933AWhs7xAFNMwPrNKN6WlC9XVA9LaieFzR6xRPvHf551_Hsisn7mp9z_AM_Ff49
CitedBy_id	crossref_primary_10_3389_fsurg_2022_988392 crossref_primary_10_2147_DDDT_S505020 crossref_primary_10_1097_MD_0000000000032010 crossref_primary_10_1186_s12884_025_07809_4 crossref_primary_10_1038_s41598_024_62824_3 crossref_primary_10_1097_MD_0000000000040295 crossref_primary_10_1002_ibra_12104
Cites_doi	0161912/AIM.0010 10.1136/bmjopen-2019-030580 10.1080/08941939.2019.1710626 10.1016/S0140-6736(11)60245-6 10.1016/j.sjpain.2010.01.001 10.1093/bja/aeq158 10.2147/JPR.S144066 10.1016/j.ajem.2012.07.027 10.1016/j.jclinane.2020.110071 10.1097/00000542-200010000-00040 10.1007/s40262-016-0383-6 10.1007/s11916-017-0607-y 10.1007/s11916-018-0690-8 10.2147/DDDT.S224553 10.5812/aapm.100178 10.1097/EJA.0000000000000366 10.1186/s12871-019-0857-9 10.1002/14651858.CD012033.pub4 10.4103/ija.IJA_605_18 10.1111/cns.12072 10.1016/B978-0-443-06959-8.00087-X 10.1007/978-3-319-42925-0_5
ContentType	Journal Article
Copyright	Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021
Copyright_xml	– notice: Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. – notice: 2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021
DBID	9YT ACMMV AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 88E 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR BTHHO CCPQU DWQXO FYUFA GHDGH GNUQQ K9- K9. KB0 M0R M0S M1P M2M NAPCQ PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM DOA
DOI	10.1136/bmjopen-2021-054681
DatabaseName	BMJ Open Access Journals BMJ Journals:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central BMJ Journals ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Consumer Health Database (Alumni Edition) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Consumer Health Database Health & Medical Collection (Alumni) Medical Database Psychology Database Nursing & Allied Health Premium ProQuest One Academic ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals (WRLC)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Family Health (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition BMJ Journals ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic Publicly Available Content Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7RV name: ProQuest Nursing and Allied Health Journals - PSU access expires 11/30/25. url: https://search.proquest.com/nahs sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2044-6055
ExternalDocumentID	oai_doaj_org_article_08bfdeb1530e4cedb8f7d566c6e413af PMC8679135 34916327 10_1136_bmjopen_2021_054681 bmjopen
Genre	Clinical Trial Protocol Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	China
GeographicLocations_xml	– name: China
GrantInformation_xml	– fundername: the National Key Research and Development Program of China grantid: 2018YFC2001900 – fundername: ; grantid: 2018YFC2001900
GroupedDBID	--- 4.4 53G 5VS 7RV 7X7 7~R 88E 8FI 8FJ 9YT ABUWG ACGFS ACMMV ADBBV AENEX AFKRA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BKNYI BPHCQ BTFSW BTHHO CCPQU DIK DWQXO EBS FYUFA GNUQQ GROUPED_DOAJ GX1 H13 HMCUK HYE HZ~ K9- KQ8 M0R M1P M2M M48 M~E NAPCQ O9- OK1 PGMZT PHGZT PIMPY PQQKQ PROAC PSQYO PSYQQ RHI RMJ RPM UKHRP AAYXX ADRAZ AFFHD BVXVI CITATION EJD PHGZM PJZUB PPXIY 3V. CGR CUY CVF ECM EIF NPM RHF 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-b539t-c991a8d06bf60bd2e19a98265c26231a1af5aa2532a22033ee5d75aa6589e4e03
IEDL.DBID	DOA
ISICitedReferencesCount	6
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000731910700023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2044-6055
IngestDate	Tue Oct 14 19:06:19 EDT 2025 Tue Nov 04 02:01:16 EST 2025 Thu Sep 04 16:14:56 EDT 2025 Tue Oct 07 07:11:08 EDT 2025 Thu Jan 02 22:54:47 EST 2025 Sat Nov 29 04:02:19 EST 2025 Tue Nov 18 21:41:15 EST 2025 Thu Apr 24 22:50:20 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Keywords	acute postoperative pain S(+)-ketamine multimodal analgesia esketamine pragmatic clinical trial
Language	English
License	This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-b539t-c991a8d06bf60bd2e19a98265c26231a1af5aa2532a22033ee5d75aa6589e4e03
Notes	Protocol ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 HW and C-YD are joint first authors.
ORCID	0000-0002-5348-362X 0000-0001-9814-2450
OpenAccessLink	https://doaj.org/article/08bfdeb1530e4cedb8f7d566c6e413af
PMID	34916327
PQID	2610721078
PQPubID	2040975
ParticipantIDs	doaj_primary_oai_doaj_org_article_08bfdeb1530e4cedb8f7d566c6e413af pubmedcentral_primary_oai_pubmedcentral_nih_gov_8679135 proquest_miscellaneous_2611656081 proquest_journals_2610721078 pubmed_primary_34916327 crossref_citationtrail_10_1136_bmjopen_2021_054681 crossref_primary_10_1136_bmjopen_2021_054681 bmj_journals_10_1136_bmjopen_2021_054681
PublicationCentury	2000
PublicationDate	20211216
PublicationDateYYYYMMDD	2021-12-16
PublicationDate_xml	– month: 12 year: 2021 text: 20211216 day: 16
PublicationDecade	2020
PublicationPlace	England
PublicationPlace_xml	– name: England – name: London – name: BMA House, Tavistock Square, London, WC1H 9JR
PublicationSeriesTitle	Protocol
PublicationTitle	BMJ open
PublicationTitleAbbrev	BMJ Open
PublicationTitleAlternate	BMJ Open
PublicationYear	2021
Publisher	British Medical Journal Publishing Group BMJ Publishing Group LTD BMJ Publishing Group
Publisher_xml	– name: British Medical Journal Publishing Group – name: BMJ Publishing Group LTD – name: BMJ Publishing Group
References	Richards, Rockford (R11) 2013; 31 Ithnin, Tan, Xu (R23) 2019; 63 Helander, Menard, Harmon (R9) 2017; 21 Wang, Lin, Lan (R14) 2021; 68 Mitra, Carlyle, Kodumudi (R1) 2018; 22 Rawal (R2) 2016; 33 Mendola, Cammarota, Netto (R22) 2012; 78 Kissin, Weiskopf Richard (R5) 2000; 93 Gan (R6) 2017; 10 Khademi, Kamangar, Brennan (R7) 2016; 19 Thiruvenkatarajan, Wood, Watts (R8) 2019; 19 Imani, Varrassi (R10) 2019; 9 Spreng, Dahl, Ræder (R19) 2010; 1 Ho, Tay, Yeo (R18) 2010; 105 Wang, Huang, Yang (R20) 2019; 13 Marland, Ellerton, Andolfatto (R12) 2013; 19 Brinck, Tiippana, Heesen (R15) 2018; 12 Hurley, CL (R4) 2010; 7 Liu, Li, Li (R21) 2021; 34 Peltoniemi, Hagelberg, Olkkola (R13) 2016; 55 Wu, Raja (R3) 2011; 377 Sloekers, Bos, Hoogland (R17) 2019; 9 Rawal (2022110304330800000_11.12.e054681.2) 2016; 33 Ithnin (2022110304330800000_11.12.e054681.23) 2019; 63 Mitra (2022110304330800000_11.12.e054681.1) 2018; 22 Hurley (2022110304330800000_11.12.e054681.4) 2010; 7 Liu (2022110304330800000_11.12.e054681.21) 2021; 34 2022110304330800000_11.12.e054681.3 Wang (2022110304330800000_11.12.e054681.20) 2019; 13 Wang (2022110304330800000_11.12.e054681.14) 2021; 68 2022110304330800000_11.12.e054681.13 2022110304330800000_11.12.e054681.6 2022110304330800000_11.12.e054681.5 Helander (2022110304330800000_11.12.e054681.9) 2017; 21 2022110304330800000_11.12.e054681.12 Thiruvenkatarajan (2022110304330800000_11.12.e054681.8) 2019; 19 Khademi (2022110304330800000_11.12.e054681.7) 2016; 19 Imani (2022110304330800000_11.12.e054681.10) 2019; 9 Spreng (2022110304330800000_11.12.e054681.19) 2010; 1 Brinck (2022110304330800000_11.12.e054681.15) 2018; 12 Richards (2022110304330800000_11.12.e054681.11) 2013; 31 2022110304330800000_11.12.e054681.17 2022110304330800000_11.12.e054681.18 2022110304330800000_11.12.e054681.16 Mendola (2022110304330800000_11.12.e054681.22) 2012; 78
References_xml	– volume: 19 start-page: 870 year: 2016 ident: R7 article-title: Opioid therapy and its side effects: a review publication-title: Arch Iran Med doi: 0161912/AIM.0010 – volume: 9 year: 2019 ident: R17 article-title: Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial publication-title: BMJ Open doi: 10.1136/bmjopen-2019-030580 – volume: 34 start-page: 1 year: 2021 ident: R21 article-title: Effect of pretreatment of S-Ketamine on postoperative depression for breast cancer patients publication-title: J Invest Surg doi: 10.1080/08941939.2019.1710626 – volume: 377 start-page: 2215 year: 2011 ident: R3 article-title: Treatment of acute postoperative pain publication-title: Lancet doi: 10.1016/S0140-6736(11)60245-6 – volume: 1 start-page: 100 year: 2010 ident: R19 article-title: Effects of perioperative S (+) ketamine infusion added to multimodal analgesia in patients undergoing ambulatory haemorrhoidectomy publication-title: Scand J Pain doi: 10.1016/j.sjpain.2010.01.001 – volume: 105 start-page: 371 year: 2010 ident: R18 article-title: Duloxetine reduces morphine requirements after knee replacement surgery publication-title: Br J Anaesth doi: 10.1093/bja/aeq158 – volume: 78 start-page: 757 year: 2012 ident: R22 article-title: S(+)-ketamine for control of perioperative pain and prevention of post thoracotomy pain syndrome: a randomized, double-blind study publication-title: Minerva Anestesiol – volume: 7 start-page: 2757 year: 2010 ident: R4 article-title: Acute postoperative pain publication-title: Miller’s Anesthesia – volume: 10 start-page: 2287 year: 2017 ident: R6 article-title: Poorly controlled postoperative pain: prevalence, consequences, and prevention publication-title: J Pain Res doi: 10.2147/JPR.S144066 – volume: 31 start-page: 390 year: 2013 ident: R11 article-title: Low-Dose ketamine analgesia: patient and physician experience in the ED publication-title: Am J Emerg Med doi: 10.1016/j.ajem.2012.07.027 – volume: 68 year: 2021 ident: R14 article-title: Perioperative intravenous S-ketamine for acute postoperative pain in adults: a systematic review and meta-analysis publication-title: J Clin Anesth doi: 10.1016/j.jclinane.2020.110071 – volume: 93 start-page: 1138 year: 2000 ident: R5 article-title: Preemptive analgesia publication-title: Anesthesiology doi: 10.1097/00000542-200010000-00040 – volume: 55 start-page: 1059 year: 2016 ident: R13 article-title: Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy publication-title: Clin Pharmacokinet doi: 10.1007/s40262-016-0383-6 – volume: 21 year: 2017 ident: R9 article-title: Multimodal analgesia, current concepts, and acute pain considerations publication-title: Curr Pain Headache Rep doi: 10.1007/s11916-017-0607-y – volume: 22 year: 2018 ident: R1 article-title: New advances in acute postoperative pain management publication-title: Curr Pain Headache Rep doi: 10.1007/s11916-018-0690-8 – volume: 13 start-page: 4135 year: 2019 ident: R20 article-title: Pharmacokinetics and safety of Esketamine in Chinese patients undergoing painless gastroscopy in comparison with ketamine: a randomized, open-label clinical study publication-title: Drug Des Devel Ther doi: 10.2147/DDDT.S224553 – volume: 9 year: 2019 ident: R10 article-title: Ketamine as adjuvant for acute pain management publication-title: Anesth Pain Med doi: 10.5812/aapm.100178 – volume: 33 start-page: 160 year: 2016 ident: R2 article-title: Current issues in postoperative pain management publication-title: Eur J Anaesthesiol doi: 10.1097/EJA.0000000000000366 – volume: 19 year: 2019 ident: R8 article-title: The intraoperative use of non-opioid adjuvant analgesic agents: a survey of anaesthetists in Australia and New Zealand publication-title: BMC Anesthesiol doi: 10.1186/s12871-019-0857-9 – volume: 12 start-page: CD012033 year: 2018 ident: R15 article-title: Perioperative intravenous ketamine for acute postoperative pain in adults publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD012033.pub4 – volume: 63 start-page: 126 year: 2019 ident: R23 article-title: Low-Dose S+ ketamine in target-controlled intravenous anaesthesia with remifentanil and propofol for open gynaecological surgery: a randomised controlled trial publication-title: Indian J Anaesth doi: 10.4103/ija.IJA_605_18 – volume: 19 start-page: 381 year: 2013 ident: R12 article-title: Ketamine: use in anesthesia publication-title: CNS Neurosci Ther doi: 10.1111/cns.12072 – volume: 7 start-page: 2757 year: 2010 ident: 2022110304330800000_11.12.e054681.4 article-title: Acute postoperative pain publication-title: Miller’s Anesthesia doi: 10.1016/B978-0-443-06959-8.00087-X – volume: 31 start-page: 390 year: 2013 ident: 2022110304330800000_11.12.e054681.11 article-title: Low-Dose ketamine analgesia: patient and physician experience in the ED publication-title: Am J Emerg Med doi: 10.1016/j.ajem.2012.07.027 – volume: 21 year: 2017 ident: 2022110304330800000_11.12.e054681.9 article-title: Multimodal analgesia, current concepts, and acute pain considerations publication-title: Curr Pain Headache Rep doi: 10.1007/s11916-017-0607-y – ident: 2022110304330800000_11.12.e054681.16 doi: 10.1007/978-3-319-42925-0_5 – ident: 2022110304330800000_11.12.e054681.18 doi: 10.1093/bja/aeq158 – volume: 12 start-page: CD012033 year: 2018 ident: 2022110304330800000_11.12.e054681.15 article-title: Perioperative intravenous ketamine for acute postoperative pain in adults publication-title: Cochrane Database Syst Rev – ident: 2022110304330800000_11.12.e054681.12 doi: 10.1111/cns.12072 – volume: 33 start-page: 160 year: 2016 ident: 2022110304330800000_11.12.e054681.2 article-title: Current issues in postoperative pain management publication-title: Eur J Anaesthesiol doi: 10.1097/EJA.0000000000000366 – volume: 19 year: 2019 ident: 2022110304330800000_11.12.e054681.8 article-title: The intraoperative use of non-opioid adjuvant analgesic agents: a survey of anaesthetists in Australia and New Zealand publication-title: BMC Anesthesiol doi: 10.1186/s12871-019-0857-9 – volume: 9 year: 2019 ident: 2022110304330800000_11.12.e054681.10 article-title: Ketamine as adjuvant for acute pain management publication-title: Anesth Pain Med doi: 10.5812/aapm.100178 – ident: 2022110304330800000_11.12.e054681.13 doi: 10.1007/s40262-016-0383-6 – ident: 2022110304330800000_11.12.e054681.3 doi: 10.1016/S0140-6736(11)60245-6 – ident: 2022110304330800000_11.12.e054681.5 doi: 10.1097/00000542-200010000-00040 – volume: 68 year: 2021 ident: 2022110304330800000_11.12.e054681.14 article-title: Perioperative intravenous S-ketamine for acute postoperative pain in adults: a systematic review and meta-analysis publication-title: J Clin Anesth doi: 10.1016/j.jclinane.2020.110071 – volume: 22 year: 2018 ident: 2022110304330800000_11.12.e054681.1 article-title: New advances in acute postoperative pain management publication-title: Curr Pain Headache Rep doi: 10.1007/s11916-018-0690-8 – ident: 2022110304330800000_11.12.e054681.6 doi: 10.2147/JPR.S144066 – volume: 1 start-page: 100 year: 2010 ident: 2022110304330800000_11.12.e054681.19 article-title: Effects of perioperative S (+) ketamine infusion added to multimodal analgesia in patients undergoing ambulatory haemorrhoidectomy publication-title: Scand J Pain doi: 10.1016/j.sjpain.2010.01.001 – volume: 13 start-page: 4135 year: 2019 ident: 2022110304330800000_11.12.e054681.20 article-title: Pharmacokinetics and safety of Esketamine in Chinese patients undergoing painless gastroscopy in comparison with ketamine: a randomized, open-label clinical study publication-title: Drug Des Devel Ther doi: 10.2147/DDDT.S224553 – ident: 2022110304330800000_11.12.e054681.17 doi: 10.1136/bmjopen-2019-030580 – volume: 34 start-page: 1 year: 2021 ident: 2022110304330800000_11.12.e054681.21 article-title: Effect of pretreatment of S-Ketamine on postoperative depression for breast cancer patients publication-title: J Invest Surg doi: 10.1080/08941939.2019.1710626 – volume: 63 start-page: 126 year: 2019 ident: 2022110304330800000_11.12.e054681.23 article-title: Low-Dose S+ ketamine in target-controlled intravenous anaesthesia with remifentanil and propofol for open gynaecological surgery: a randomised controlled trial publication-title: Indian J Anaesth doi: 10.4103/ija.IJA_605_18 – volume: 19 start-page: 870 year: 2016 ident: 2022110304330800000_11.12.e054681.7 article-title: Opioid therapy and its side effects: a review publication-title: Arch Iran Med – volume: 78 start-page: 757 year: 2012 ident: 2022110304330800000_11.12.e054681.22 article-title: S(+)-ketamine for control of perioperative pain and prevention of post thoracotomy pain syndrome: a randomized, double-blind study publication-title: Minerva Anestesiol
SSID	ssj0000459552
Score	2.3176541
Snippet	IntroductionPostoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the... Postoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of... Introduction Postoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the...
SourceID	doaj pubmedcentral proquest pubmed crossref bmj
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	e054681
SubjectTerms	acute postoperative pain Adult Anaesthesia Analgesics Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Angina pectoris Benzodiazepines Blood pressure Clinical medicine Clinical trials Cognitive ability Consciousness Delirium Drug dosages esketamine General anesthesia Humans Informed consent Ketamine Ketamine - therapeutic use Medical personnel Multicenter Studies as Topic multimodal analgesia Narcotics Orthopedics Pain Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - etiology Patients Postoperative period pragmatic clinical trial Randomized Controlled Trials as Topic S(+)-ketamine Thoracic surgery
SummonAdditionalLinks	– databaseName: BMJ Journals dbid: RMJ link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGQNNeuF8CAxmJh040a2zHicNbQasQaNNEQdpb5OsodGnVZv2P_CuOnQsUoQnxVMk5x7Xjz_F3Evs7CL1yHBZVzXmcJakPUIoUnoMOohRFNGWFUkI1ySby01Nxfl6c7SDanYVRl9982qgj-G1ONHiNpqoeETIidGSBYGSCHPlX0zfQTR_beCR_OvnQv1cBilLwkGiHJmkKTeC8FRsiLOuqB2xQiKJDZftoj6VAklhILAMGWytUEPL_G_v8cxPlb6vS5M7_9Ocuut1yUDxuQHMP7djqPto7ab-yP0A_zgCWUF8jCo5n_p83QcsVTwevD-PvtpaXYImB8GKpr2qLl16fo_dYylkFbjiIe6zf4KBhi70kxAJw17jhsJUxdMsOMayYZgGQs2aIw60DcNr5EDd7yjY2brfUz73BciUvgtIs7s514pB8BA-m48lxPP0Yj5uCw4foy-T487v3cZvyIVacFXWsga5KYZJMuSxRhlpSyAIiIK4p8DQiiXRcSsoZlZQmjFnLTQ4lwKMKm9qEPUK71aKyTxDOXZ45bagwGoLYRKpCioIY5wRlOhVJhAYwKGU7ZddliIZYVrYjVnqIlM34RIh2iCh1K53uM3jMr3ca9k7LRjnkevO3Hmq9qZf9DgWL1UXZPkXKRChnYHXlLLGptkYJlxsg5DqzQEaki9BBB9RfHYMY2YvgAReM0Mv-Mgyp_zQkKwvo8TZBhsm343GD674l3eyIUL6F-K2mbl-pZl-DUrlXcySMP_33W_0M7Ye5SWhMsgO0W6-u7HN0S2_q2Xr1Ikz1n0HaVKU priority: 102 providerName: BMJ Publishing Group Ltd – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELbYLkJ74f0oLMhIHLqi0SZ2nAcX1EWtkBBVRUHaW-TnUrabhDbb_8i_Yuy4WYpQL1ydGWmcfPbM2JNvEHpjGDhVyViQhLFNUPIY9kEDWYqIJKG5EJlom02k02l2fp7P_IHb2pdVbvdEt1GrStoz8lOI9C2VF3i09_XPwHaNsrervoXGATq0TGVxDx2ejaezL90pCwQsOWPE0w1FNDkVVz9sXypAB4E8msWJZbQ-gNEdx-T4-_8VdP5dO_mHM5rc-99p3Ed3fRiKRy1uHqBbunyI7nz2F-2P0K8ZIBNm0PKC44W1YuPoXPF88PYkuNQNvwJJDDEv5vK60bi2FB2dRs0XJahhx--xfocdjS22rBAVQK9Vw66a0U1RDzE4TVUB6rQaYvfuAJ96OcRtWdlGB76qfmkF6hW_cGSzePtrJ3b9R_BgPpqMg_mnYNQOnDxG3ybjrx8-Br7rQyAYzZtAQsTKMxUmwiShUERHOc8hCWKSQKgW8YgbxjlhlHBCQkq1ZiqFEQilch3rkD5BvbIq9TOEU5MmRiqSKQl5bMhFzrM8UsZkhMo4C_toAB--8Kt2XbiEiCaFx0hhMVK0GOkjskVHIT17um3isdyvNOyU6pY8ZL_4mYVdJ2qZv91Atboo_EZShJkwChwso6GOpVYiM6mCmFwmGuIRbvroeAu8m4ndoK6PXneP4ZPa2yFeakCPlXFMTNaOpy3GO0toDFkEJWkfpTvo3zF190m5-O7Iyi2hY0TZ8_1mvUBHbkFGJIiSY9RrVtf6JbotN81ivXrlV_VvBfRaQw priority: 102 providerName: ProQuest
Title	Perioperative intravenous S(+)-ketamine for acute postoperative pain in adults: study protocol for a multicentre, randomised, open-label, positive-controlled, pragmatic clinical trial (SAFE-SK-A trial)
URI	https://bmjopen.bmj.com/content/11/12/e054681.full https://www.ncbi.nlm.nih.gov/pubmed/34916327 https://www.proquest.com/docview/2610721078 https://www.proquest.com/docview/2611656081 https://pubmed.ncbi.nlm.nih.gov/PMC8679135 https://doaj.org/article/08bfdeb1530e4cedb8f7d566c6e413af
Volume	11
WOSCitedRecordID	wos000731910700023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVADZ databaseName: BMJ Journals customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: RMJ dateStart: 20110101 isFulltext: true titleUrlDefault: http://www.bmj.com/thebmj providerName: BMJ Publishing Group Ltd – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: M0R dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Nursing and Allied Health Journals - PSU access expires 11/30/25. customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: 7RV dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: M2M dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2044-6055 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000459552 issn: 2044-6055 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bjxIxFG7c1RhfjNcVXUlNfGAjk51pp3PxjTUQLxlCQA0-TXpVlB0IzPIf_VeetgOCMeuLLw20PZNTztfTczLlOwi9NAwOVclYkISxTVDyGPyggSxFRJLQXIhM-GIT6XCYTaf5aK_Ul70T5umB_Q93HmbCKHAojIY6llqJzKQKYhCZaPC_3FjvC1HPXjLlfHDMcsZIQzMU0eRcXH639agAFQTyZxYnlsn6CHoPDiTH2_-3YPPPO5N7h9DgHrrbRI-457W-j27o6gG6XTTvxx-inyMAFCjg6bzxzD5k41hY8aTz6iz4oWt-CTMxhKqYy6ta46Vl1thJLPmsAjHsaDnWr7Fjn8WWzGEBiPFi2F1CdBrqLoazTi0ALFp1sVs6wErPu9jfBtvooLkMP7cTliv-1XHE4u0_MrErG4I7k96gH0w-BD3fcfYIfRr0P755GzTFGgLBaF4HEgJNnqkwESYJhSI6ynkOuQuTBCKsiEfcMM4Jo4QTElKqNVMp9EAElOtYh_QxOq4WlX6CcGrSxEhFMiUh_Qy5yHmWR8qYjFAZZ2ELdcBuZbPZ1qXLY2hSNiYurYlLb-IWIlvjlrIhPbe1N-bXC3V3QkvP-XH99AuLmt1US9jtOgDGZQPj8l8wbqHTLeZ-LwyyW0tfB1FcC73YDYNJ7UsdXmlAj53jCJSsHiceojtNaAzBPyVpC6UH4D1Q9XCkmn1zHOOWhzGi7On_WNszdMftuogEUXKKjuvVlX6ObslNPVuv2ugoHX-27TR1bdZGNy_6w9G47bY0tEVoPxekgJHRu2L0Bb6Ni_e_AFD3VY0
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLa2gYAX7ozCACOB1IlGS-w4FySECqza1K2a6Ib2FnzdCl1a2q6IP8X_4F9x7FxGEerbHnh17MhxvnP8neT4Owi9MAw2VcmYF_mhDVDSEPyggShFBJLQVIhEFMUm4l4vOT5OD1bQz-osjE2rrHyic9RqJO038i1g-lbKC3a0t-Nvnq0aZf-uViU0Clh09Y_vELJN3-x-gPf7kpDO9uH7Ha-sKuAJRtOZJ4ER8UT5kTCRLxTRQcpTINlMEqACAQ-4YZwTRgknxKdUa6ZiaIGtOtWh9incdxVdAT8e2BSy-OOn-psO0KOUMVKKGwU02hJnX2wVLMAigaidhZHVz16F1oVt0FUL-BfF_TtT84-tr3Prf1u02-hmSbJxu7CKO2hF53fRtf0yjeAe-nUAdgcrVqie44F96rkTq8X95qtN76ue8TPoiYHRYy7PZxqPrQBJPWLMBzkMw069ZPoaO5FebDUvRmBYxTDscjXdkuoWBkqgRmBTWrWwe1dgfXrYwkXS3Fx75ZmBoe0wnvATJ6WLq4Or2FVXwc1-u7Pt9bteu2jYvI-OLmUhH6C1fJTrhwjHJo6MVCRREqJ0n4uUJ2mgjEkIlWHiN1ATgJaVPmmauXCPRlmJycxiMisw2UCkQmMmS214W6JkuHxQqx40LqRRlnd_Z2Fed7W65q5hNDnJSjeZ-YkwCugDo74OpVYiMbGCiENGGtgWNw20UQH94sEuUN5Az-vL8Ertvy-ea0CP7eN0puw81gubqmdCQ4iRKIkbKF6wtoWpLl7JB6dOit3KVQaUPVo-rWfo-s7h_l62t9vrPkY3nDMIiBdEG2htNjnXT9BVOZ8NppOnzp9g9PmybfE3OIC07A
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3bbhMxELXagipeuEMDBYwEUiqyyq693gsSQoE2ogpEESlS3xZf20C6CUkaxK_xB_wVY--lBKG89YFXrx053jPjM-vxGYSeGQabqmTMi_zQBihpCH7QQJQiAkloKkQiimITcb-fHB-ngw30s7oLY9MqK5_oHLWaSPuNvA1M30p5wY7WNmVaxGC_-3r6zbMVpOxJa1VOo4BIT__4DuHb_NXhPrzr54R0D47evvPKCgOeYDRdeBLYEU-UHwkT-UIRHaQ8BcLNJAFaEPCAG8Y5YZRwQnxKtWYqhhbYtlMdap_C726iK7E9HLRpg_7H-vsOUKWUMVIKHQU0aouzL7YiFuCSQATPwshqaW9C68qW6CoH_Ivu_p21-cc22L3xPy_gTXS9JN-4U1jLLbSh89to-0OZXnAH_RqAPcLqFWroeGRXYOlEbPGw-WLP-6oX_Ax6YmD6mMvzhcZTK0xSj5jyUQ7DsFM1mb_ETrwXWy2MCRhcMQy7HE63vLqFgSqoCdiaVi3s3htYpR63cJFMt9ReeZdgbDtMZ_zESezi6kIrdlVXcHPY6R54w57XKRr27qJPl7KQ99BWPsn1DsKxiSMjFUmUhOjd5yLlSRooYxJCZZj4DdQE0GWlr5pnLgykUVbiM7P4zAp8NhCpkJnJUjPeli4Zrx_UqgdNC8mU9d3fWMjXXa3euWuYzE6y0n1mfiKMAlrBqK9DqZVITKwgEpGRBhbGTQPtVqC_-GMXiG-gp_VjeKX2TIznGtBj-zj9KTuP-4V91TOhIcROlMQNFK9Y3spUV5_ko1Mn0W5lLAPKHqyf1hO0DSaYvT_s9x6ia84vBMQLol20tZid60foqlwuRvPZY-daMPp82ab4G4a_vYk
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Perioperative+intravenous+S%28%2B%29-ketamine+for+acute+postoperative+pain+in+adults%3A+study+protocol+for+a+multicentre%2C+randomised%2C+open-label%2C+positive-controlled%2C+pragmatic+clinical+trial+%28SAFE-SK-A+trial%29&rft.jtitle=BMJ+open&rft.au=Wang%2C+Hong&rft.au=Duan%2C+Chong-Yang&rft.au=Huang%2C+Wen-Qi&rft.au=Zhao%2C+Ping&rft.date=2021-12-16&rft.eissn=2044-6055&rft.volume=11&rft.issue=12&rft.spage=e054681&rft_id=info:doi/10.1136%2Fbmjopen-2021-054681&rft_id=info%3Apmid%2F34916327&rft.externalDocID=34916327
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2044-6055&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2044-6055&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2044-6055&client=summon