Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial

AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. Chil...

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Vydáno v:	British journal of ophthalmology Ročník 104; číslo 3; s. 363 - 368
Hlavní autoři:	Lam, Carly Siu Yin, Tang, Wing Chun, Tse, Dennis Yan-yin, Lee, Roger Pak Kin, Chun, Rachel Ka Man, Hasegawa, Keigo, Qi, Hua, Hatanaka, Takashi, To, Chi Ho
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.03.2020 BMJ Publishing Group LTD BMJ Publishing Group
Témata:	Adolescent Child Clinical outcomes Clinical Science Clinical trials Disease Progression Double-Blind Method Equipment Design Eyeglasses Female Follow-Up Studies Humans Male Myopia myopia control Myopia, Degenerative - physiopathology Myopia, Degenerative - therapy myopic defocus Pediatrics Prospective Studies Refraction, Ocular - physiology simultaneous vision spectacle lens Time Factors Treatment Outcome Hong Kong China China myopia myopic defocus simultaneous vision myopia control spectacle lens
ISSN:	0007-1161, 1468-2079, 1468-2079
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Abstract	AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.Results160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were −0.41±0.06 D in the DIMS group and −0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference −0.44±0.09 D, 95% CI −0.73 to −0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.ConclusionsDaily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.Trial registration number NCT02206217.
AbstractList	To determine if 'Defocus Incorporated Multiple Segments' (DIMS) spectacle lenses slow childhood myopia progression. A 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8-13 years, with myopia between -1.00 and -5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals. 160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were -0.41±0.06 D in the DIMS group and -0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference -0.44±0.09 D, 95% CI -0.73 to -0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses. Daily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression. NCT02206217. AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.Results160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were −0.41±0.06 D in the DIMS group and −0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference −0.44±0.09 D, 95% CI −0.73 to −0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.ConclusionsDaily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.Trial registration numberNCT02206217. AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.Results160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were −0.41±0.06 D in the DIMS group and −0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference −0.44±0.09 D, 95% CI −0.73 to −0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.ConclusionsDaily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.Trial registration number NCT02206217. To determine if 'Defocus Incorporated Multiple Segments' (DIMS) spectacle lenses slow childhood myopia progression.AIMTo determine if 'Defocus Incorporated Multiple Segments' (DIMS) spectacle lenses slow childhood myopia progression.A 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8-13 years, with myopia between -1.00 and -5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.METHODSA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8-13 years, with myopia between -1.00 and -5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were -0.41±0.06 D in the DIMS group and -0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference -0.44±0.09 D, 95% CI -0.73 to -0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.RESULTS160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were -0.41±0.06 D in the DIMS group and -0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference -0.44±0.09 D, 95% CI -0.73 to -0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.Daily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.CONCLUSIONSDaily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.NCT02206217.TRIAL REGISTRATION NUMBERNCT02206217.
Author	Chun, Rachel Ka Man Tang, Wing Chun Lee, Roger Pak Kin Lam, Carly Siu Yin Qi, Hua Hasegawa, Keigo To, Chi Ho Tse, Dennis Yan-yin Hatanaka, Takashi
AuthorAffiliation	2 Hoya Corporation , Tokyo , Japan 1 Centre for Myopia Research, School of Optometry , The Hong Kong Polytechnic University , Hung Hom , Hong Kong
AuthorAffiliation_xml	– name: 2 Hoya Corporation , Tokyo , Japan – name: 1 Centre for Myopia Research, School of Optometry , The Hong Kong Polytechnic University , Hung Hom , Hong Kong
Author_xml	– sequence: 1 givenname: Carly Siu Yin orcidid: 0000-0002-6808-5018 surname: Lam fullname: Lam, Carly Siu Yin email: carly.lam@polyu.edu.hk organization: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong – sequence: 2 givenname: Wing Chun surname: Tang fullname: Tang, Wing Chun organization: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong – sequence: 3 givenname: Dennis Yan-yin surname: Tse fullname: Tse, Dennis Yan-yin organization: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong – sequence: 4 givenname: Roger Pak Kin surname: Lee fullname: Lee, Roger Pak Kin organization: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong – sequence: 5 givenname: Rachel Ka Man surname: Chun fullname: Chun, Rachel Ka Man organization: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong – sequence: 6 givenname: Keigo surname: Hasegawa fullname: Hasegawa, Keigo organization: Hoya Corporation, Tokyo, Japan – sequence: 7 givenname: Hua surname: Qi fullname: Qi, Hua organization: Hoya Corporation, Tokyo, Japan – sequence: 8 givenname: Takashi surname: Hatanaka fullname: Hatanaka, Takashi organization: Hoya Corporation, Tokyo, Japan – sequence: 9 givenname: Chi Ho surname: To fullname: To, Chi Ho organization: Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31142465$$D View this record in MEDLINE/PubMed
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Keywords	myopia myopic defocus simultaneous vision myopia control spectacle lens
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article-title: 3 year effectiveness of a dual-focus 1 day soft contact lens for myopia control publication-title: Contact Lens and Anterior Eye doi: 10.1016/j.clae.2018.03.097 – volume: 6 start-page: 133 year: 2015 ident: 2020060209150896000_104.3.363.10 article-title: Controlling myopia progression in children and adolescents publication-title: Adolesc Health Med Ther – ident: 2020060209150896000_104.3.363.30 doi: 10.1167/iovs.10-6631 – ident: 2020060209150896000_104.3.363.11 doi: 10.1016/j.ophtha.2006.05.062 – volume: 126 start-page: 113 year: 2019 ident: 2020060209150896000_104.3.363.14 article-title: Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control publication-title: Ophthalmology doi: 10.1016/j.ophtha.2018.05.029 – ident: 2020060209150896000_104.3.363.26 doi: 10.1136/bmj.313.7057.570 – ident: 2020060209150896000_104.3.363.20 doi: 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Snippet	AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised... To determine if 'Defocus Incorporated Multiple Segments' (DIMS) spectacle lenses slow childhood myopia progression. A 2-year double-masked randomised... To determine if 'Defocus Incorporated Multiple Segments' (DIMS) spectacle lenses slow childhood myopia progression.AIMTo determine if 'Defocus Incorporated...
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StartPage	363
SubjectTerms	Adolescent Child Clinical outcomes Clinical Science Clinical trials Disease Progression Double-Blind Method Equipment Design Eyeglasses Female Follow-Up Studies Humans Male Myopia myopia control Myopia, Degenerative - physiopathology Myopia, Degenerative - therapy myopic defocus Pediatrics Prospective Studies Refraction, Ocular - physiology simultaneous vision spectacle lens Time Factors Treatment Outcome
Title	Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial
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Volume	104
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