Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

ObjectiveMutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised assay design due to the lack of universally mutated genes. In contrast, early methylation alterations are restricted to defined genom...

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Bibliographic Details
Published in:	Gut Vol. 67; no. 11; pp. 1995 - 2005
Main Authors:	Barault, Ludovic, Amatu, Alessio, Siravegna, Giulia, Ponzetti, Agostino, Moran, Sebastian, Cassingena, Andrea, Mussolin, Benedetta, Falcomatà, Chiara, Binder, Alexandra M, Cristiano, Carmen, Oddo, Daniele, Guarrera, Simonetta, Cancelliere, Carlotta, Bustreo, Sara, Bencardino, Katia, Maden, Sean, Vanzati, Alice, Zavattari, Patrizia, Matullo, Giuseppe, Truini, Mauro, Grady, William M, Racca, Patrizia, Michels, Karin B, Siena, Salvatore, Esteller, Manel, Bardelli, Alberto, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 01.11.2018
Subjects:	Adult Aged Antineoplastic Agents - therapeutic use Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biopsy Cell Line, Tumor Cell-Free Nucleic Acids - drug effects Cell-Free Nucleic Acids - genetics Cell-Free Nucleic Acids - metabolism Chemotherapy Clinical trials Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Datasets Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics DNA microarrays Drug Monitoring - methods Epigenetics Female Gene expression Genomes Humans Longitudinal Studies Male Metastases Metastasis Middle Aged Mutation Oligonucleotide Array Sequence Analysis - methods Patients Pharmacodynamics Polymerase Chain Reaction Population studies Studies Treatment Outcome Tumors screening tumour markers colorectal cancer chemotherapy methylation
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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