Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases

BackgroundToll-like receptor 9 (TLR9) agonists induce inflammatory responses that promote the killing of infectious micro-organisms, cancer cells and develop adaptive immune responses. Their ability as immunomodulators to enhance the activity of checkpoint inhibitors (CPI) in treating liver tumors i...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 12; no. 7; p. e008837
Main Authors:	Ghosh, Chandra C, Cournoyer, Lauren, Liu, Yujia, Ballarin, Alizee, Layman, Ilan B, LaPorte, Jason, Morrissey, Molly, Fraser, Kayla, Perati, Shriya, Cox, Bryan F, Yakirevich, Evgeny, Treaba, Diana O, Murtha, Timothy D, Guha, Prajna, Katz, Steven C, Davar, Diwakar
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 22.07.2024 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Animals Antigen presentation Bioluminescence Cell Line, Tumor Clinical/Translational Cancer Immunotherapy Costs Drug Delivery Systems Drug dosages Humans Immune Checkpoint Inhibitor Immune checkpoint inhibitors Immune Checkpoint Inhibitors - administration & dosage Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Inflammation Liver Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - secondary Melanoma Metastasis Mice Mice, Inbred C57BL Myeloid-derived suppressor cell - MDSC Myeloid-Derived Suppressor Cells - drug effects Myeloid-Derived Suppressor Cells - immunology Myeloid-Derived Suppressor Cells - metabolism Original Research Patient satisfaction Toll-like receptor - TLR Tumor microenvironment - TME Tumors Myeloid-derived suppressor cell - MDSC Toll-like receptor - TLR Immune Checkpoint Inhibitor Tumor microenvironment - TME
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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