Multimodal profiling of chordoma immunity reveals distinct immune contextures

BackgroundChordomas are rare cancers from the axial skeleton which present a challenging clinical management with limited treatment options due to their anatomical location. In recent years, a few clinical trials demonstrated that chordomas can respond to immunotherapy. However, an in-depth portraya...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 12; no. 1; p. e008138
Main Authors:	van Oost, Siddh, Meijer, Debora M, Ijsselsteijn, Marieke E, Roelands, Jessica P, van den Akker, Brendy E M W, van der Breggen, Ruud, Briaire-de Bruijn, Inge H, van der Ploeg, Manon, Wijers-Koster, Pauline M, Polak, Samuel B, Peul, Wilco C, van der Wal, Robert J P, de Miranda, Noel F C C, Bovee, Judith V M G
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 25.01.2024 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original research
Subjects:	Antibodies Antigens Basic Tumor Immunology Chordoma - genetics Chordoma - pathology Chordoma - therapy Cytotoxicity Dendritic Cells Gene expression Gene Expression Profiling Humans Immunity (Disease) Immunotherapy Lymphocytes Medical research Metastasis Morphology Proteins Receptors, Antigen, T-Cell - genetics Sarcoma Standard scores T-Lymphocytes Tumor Microenvironment Tumors Netherlands Tumor Microenvironment Dendritic Cells Sarcoma T-Lymphocytes Immunotherapy
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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