Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

BackgroundThe composition of the tumor immune microenvironment (TIME) associated with good prognosis generally also predicts the success of immunotherapy, and both entail the presence of pre-existing tumor-specific T cells. Here, the blueprint of the TIME associated with such an ongoing tumor-specif...

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Veröffentlicht in:	Journal for immunotherapy of cancer Jg. 10; H. 2; S. e004346
Hauptverfasser:	Abdulrahman, Ziena, Santegoets, Saskia J, Sturm, Gregor, Charoentong, Pornpimol, Ijsselsteijn, Marieke E, Somarakis, Antonios, Höllt, Thomas, Finotello, Francesca, Trajanoski, Zlatko, van Egmond, Sylvia L, Mustafa, Dana A M, Welters, Marij J P, de Miranda, Noel F C C, van der Burg, Sjoerd H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group Ltd 01.02.2022 BMJ Publishing Group LTD BMJ Publishing Group
Schriftenreihe:	Original research
Schlagworte:	Antigens Basic Tumor Immunology Cancer Cancer therapies Chemokines - metabolism Cytokines Female Gene expression Head & neck cancer Human papillomavirus Humans Immunotherapy Lymphocytes Male Medical prognosis Monitoring, Immunologic - methods Patients Quality control Software Squamous cell carcinoma Surgery T-Lymphocytes - metabolism Throat cancer tumor microenvironment Tumor Microenvironment - immunology Tumor necrosis factor-TNF Tumors United States > US Netherlands Germany immunotherapy tumor microenvironment
ISSN:	2051-1426, 2051-1426
Online-Zugang:	Volltext
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