Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

BackgroundThe composition of the tumor immune microenvironment (TIME) associated with good prognosis generally also predicts the success of immunotherapy, and both entail the presence of pre-existing tumor-specific T cells. Here, the blueprint of the TIME associated with such an ongoing tumor-specif...

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Vydáno v:	Journal for immunotherapy of cancer Ročník 10; číslo 2; s. e004346
Hlavní autoři:	Abdulrahman, Ziena, Santegoets, Saskia J, Sturm, Gregor, Charoentong, Pornpimol, Ijsselsteijn, Marieke E, Somarakis, Antonios, Höllt, Thomas, Finotello, Francesca, Trajanoski, Zlatko, van Egmond, Sylvia L, Mustafa, Dana A M, Welters, Marij J P, de Miranda, Noel F C C, van der Burg, Sjoerd H
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England BMJ Publishing Group Ltd 01.02.2022 BMJ Publishing Group LTD BMJ Publishing Group
Edice:	Original research
Témata:	Antigens Basic Tumor Immunology Cancer Cancer therapies Chemokines - metabolism Cytokines Female Gene expression Head & neck cancer Human papillomavirus Humans Immunotherapy Lymphocytes Male Medical prognosis Monitoring, Immunologic - methods Patients Quality control Software Squamous cell carcinoma Surgery T-Lymphocytes - metabolism Throat cancer tumor microenvironment Tumor Microenvironment - immunology Tumor necrosis factor-TNF Tumors United States > US Netherlands Germany immunotherapy tumor microenvironment
ISSN:	2051-1426, 2051-1426
On-line přístup:	Získat plný text
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