CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden

BackgroundExpression of CD103 and CD39 has been found to pinpoint tumor-reactive CD8+ T cells in a variety of solid cancers. We aimed to investigate whether these markers specifically identify neoantigen-specific T cells in colorectal cancers (CRCs) with low mutation burden.Experimental designWhole-...

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Veröffentlicht in:	Journal for immunotherapy of cancer Jg. 11; H. 2; S. e005887
Hauptverfasser:	van den Bulk, Jitske, van der Ploeg, Manon, Ijsselsteijn, Marieke E, Ruano, Dina, van der Breggen, Ruud, Duhen, Rebekka, Peeters, Koen C M J, Fariña-Sarasqueta, Arantza, Verdegaal, Els M E, van der Burg, Sjoerd H, Duhen, Thomas, de Miranda, Noel F C C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group Ltd 01.02.2023 BMJ Publishing Group LTD BMJ Publishing Group
Schriftenreihe:	Original research
Schlagworte:	Antigens Basic Tumor Immunology Cancer CD8-Positive T-Lymphocytes Colorectal cancer Colorectal Neoplasms Cytotoxicity Gastrointestinal Neoplasms Humans Immunotherapy Lymphocytes Lymphocytes, Tumor-Infiltrating Mutation Patients Pharmacy Rectum T cell receptors T-Lymphocyte Subsets - pathology T-Lymphocytes, Cytotoxic Tumors Netherlands United Kingdom > UK United States > US Basel Switzerland Massachusetts England Switzerland CD8-Positive T-Lymphocytes Antigens Gastrointestinal Neoplasms Lymphocytes, Tumor-Infiltrating Immunotherapy
ISSN:	2051-1426, 2051-1426
Online-Zugang:	Volltext
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