Dichotomous and stable gamma delta T-cell number and function in healthy individuals

BackgroundGamma-delta (γδ) T lymphocytes are primed to potently respond to pathogens and transformed cells by recognizing a broad range of antigens. However, adoptive immunotherapy with γδT cells has exhibited mixed treatment responses. Better understanding of γδT cell biology and stratifying health...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 9; no. 5; p. e002274
Main Authors:	Ou, Lingling, Wang, Huaishan, Liu, Qin, Zhang, Jie, Lu, Hezhe, Luo, Liangping, Shi, Changzheng, Lin, Shaoqiang, Dong, Liyun, Guo, Yeye, Huang, Lili, Zhu, Jinjin, Yin, Xiangfan, Huang, Alexander C, Karakousis, Giorgos, Schuchter, Lynn, Amaravadi, Ravi, Zheng, Cathy, Fan, Yi, Guo, Wei, Xu, Xiaowei
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 01.05.2021 BMJ Publishing Group
Series:	Original research
Subjects:	Adult Antibodies Antigens Biomarkers - metabolism Cancer Cell Line, Tumor Cell Movement Cell Proliferation - drug effects Clinical trials Clinical/Translational Cancer Immunotherapy Coculture Techniques Cytokines Cytotoxicity Cytotoxicity, Immunologic Female Flow cytometry Gene expression Healthy Volunteers Humans Immunologic Memory Immunophenotyping Immunotherapy Intraepithelial Lymphocytes - drug effects Intraepithelial Lymphocytes - immunology Intraepithelial Lymphocytes - metabolism Lymphocyte Activation - drug effects Lymphocyte Count Lymphocytes Male Melanoma Melanoma - immunology Melanoma - metabolism Melanoma - pathology Middle Aged Patients Phenotype Skin Neoplasms - immunology Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors Young Adult Zoledronic Acid - pharmacology melanoma gamma delta T-lymphocytes adoptive cell therapy immunotherapy
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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