Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease

PurposeTo report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).Participant and methodsA 30-year-old man with confirmed COVID...

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Veröffentlicht in:	British journal of ophthalmology Jg. 104; H. 6; S. 748 - 751
Hauptverfasser:	Chen, Lu, Liu, Meizhou, Zhang, Zheng, Qiao, Kun, Huang, Ting, Chen, Miaohong, Xin, Na, Huang, Zuliang, Liu, Lei, Zhang, Guoming, Wang, Jiantao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group LTD 01.06.2020 BMJ Publishing Group
Schlagworte:	Adult Antiviral Agents - therapeutic use Betacoronavirus - pathogenicity Body temperature Clinical Science Conjunctivitis, Viral - diagnosis Conjunctivitis, Viral - drug therapy Coronavirus Infections - complications Coronavirus Infections - physiopathology Coronavirus Infections - virology Coronaviruses COVID-19 Hospitals Humans Infections Male Nasal Cavity - virology Ophthalmic Solutions - therapeutic use Pandemics Patients Pharynx - virology Pneumonia, Viral - complications Pneumonia, Viral - physiopathology Pneumonia, Viral - virology Respiratory diseases Ribavirin - therapeutic use RNA, Viral - analysis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Treatment Outcome Vital signs China infection conjunctiva
ISSN:	0007-1161, 1468-2079, 1468-2079
Online-Zugang:	Volltext
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Abstract	PurposeTo report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).Participant and methodsA 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated.ResultsSlit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2.ConclusionSARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva.
AbstractList	To report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).PURPOSETo report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).A 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated.PARTICIPANT AND METHODSA 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated.Slit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2.RESULTSSlit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2.SARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva.CONCLUSIONSARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva. To report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19). A 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated. Slit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2. SARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva. PurposeTo report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).Participant and methodsA 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated.ResultsSlit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2.ConclusionSARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva.
Author	Zhang, Zheng Liu, Meizhou Chen, Miaohong Huang, Zuliang Xin, Na Chen, Lu Wang, Jiantao Huang, Ting Zhang, Guoming Qiao, Kun Liu, Lei
AuthorAffiliation	1 Ophthalmology , Shenzhen Eye Hospital , Shenzhen , China 2 The Third People's Hospital of Shenzhen , Shenzhen , Guangdong , China
AuthorAffiliation_xml	– name: 2 The Third People's Hospital of Shenzhen , Shenzhen , Guangdong , China – name: 1 Ophthalmology , Shenzhen Eye Hospital , Shenzhen , China
Author_xml	– sequence: 1 givenname: Lu orcidid: 0000-0003-1141-8288 surname: Chen fullname: Chen, Lu email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China – sequence: 2 givenname: Meizhou surname: Liu fullname: Liu, Meizhou email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China – sequence: 3 givenname: Zheng surname: Zhang fullname: Zhang, Zheng email: zhang-guoming@163.com organization: The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China – sequence: 4 givenname: Kun surname: Qiao fullname: Qiao, Kun email: zhang-guoming@163.com organization: The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China – sequence: 5 givenname: Ting surname: Huang fullname: Huang, Ting email: zhang-guoming@163.com organization: The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China – sequence: 6 givenname: Miaohong surname: Chen fullname: Chen, Miaohong email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China – sequence: 7 givenname: Na surname: Xin fullname: Xin, Na email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China – sequence: 8 givenname: Zuliang surname: Huang fullname: Huang, Zuliang email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China – sequence: 9 givenname: Lei surname: Liu fullname: Liu, Lei email: zhang-guoming@163.com organization: The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China – sequence: 10 givenname: Guoming surname: Zhang fullname: Zhang, Guoming email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China – sequence: 11 givenname: Jiantao surname: Wang fullname: Wang, Jiantao email: zhang-guoming@163.com organization: Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32265202$$D View this record in MEDLINE/PubMed
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DOI	10.1136/bjophthalmol-2020-316304
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doi: 10.1136/bjo.80.2.159 – reference: 32277012 - Br J Ophthalmol. 2020 Jun;104(6):741
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SubjectTerms	Adult Antiviral Agents - therapeutic use Betacoronavirus - pathogenicity Body temperature Clinical Science Conjunctivitis, Viral - diagnosis Conjunctivitis, Viral - drug therapy Coronavirus Infections - complications Coronavirus Infections - physiopathology Coronavirus Infections - virology Coronaviruses COVID-19 Hospitals Humans Infections Male Nasal Cavity - virology Ophthalmic Solutions - therapeutic use Pandemics Patients Pharynx - virology Pneumonia, Viral - complications Pneumonia, Viral - physiopathology Pneumonia, Viral - virology Respiratory diseases Ribavirin - therapeutic use RNA, Viral - analysis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Treatment Outcome Vital signs
Title	Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease
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