Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China
Background and purposeWe aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator (IV tPA) and have shorter time to treatment than older patients with stroke.MethodsWe analysed data from the Chinese S...
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| Published in: | BMJ open Vol. 12; no. 6; p. e055055 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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British Medical Journal Publishing Group
01.06.2022
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| ISSN: | 2044-6055, 2044-6055 |
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| Abstract | Background and purposeWe aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator (IV tPA) and have shorter time to treatment than older patients with stroke.MethodsWe analysed data from the Chinese Stroke Center Alliance registry for patients with AIS hospitalised between August 2015 and July 2019. Patients were classified into two groups according to age: young adults (<50 years of age) and older adults (≥50 years of age).ResultsOf 793 175 patients with AIS admitted to 1471 hospitals, 9.1% (71 860) were young adults. Compared with older adults, a higher proportion of young adults received IV tPA among patients without contraindicaitons (7.2% vs 6.1%, adjusted OR (aOR) 1.13, 95% CI 1.10 to 1.17) and among patients without contraindications and with onset-to-door time ≤3.5 hours (23.6% vs 19.3%, aOR 1.20, 95% CI 1.15 to 1.24). We did not observe differences in onset-to-needle time (median hours 2.7 hours) or door-to-needle time (DNT) (median minutes 60 min) between young and older adults. The proportion of DNT ≤30 min, DNT ≤45 min and DNT ≤60 min in young and older IV tPA-treated patients were 16.9% vs 18.8%, 30.2% vs 32.8% and 50.2% vs 54.2%, respectively. Compared with older adults, young adults treated with IV tPA had lower odds of in-hospital mortality (0.5% vs 1.3%, aOR 0.54, 95% CI 0.35 to 0.82) and higher odds of independent ambulation at discharge (61.0% vs 53.6%, aOR 1.15, 95% CI 1.08 to 1.22), and the associations may be partly explained by stroke severity measured by the National Institutes of Health Stroke Scale score.ConclusionYoung adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes. |
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| AbstractList | Background and purposeWe aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator (IV tPA) and have shorter time to treatment than older patients with stroke.MethodsWe analysed data from the Chinese Stroke Center Alliance registry for patients with AIS hospitalised between August 2015 and July 2019. Patients were classified into two groups according to age: young adults (<50 years of age) and older adults (≥50 years of age).ResultsOf 793 175 patients with AIS admitted to 1471 hospitals, 9.1% (71 860) were young adults. Compared with older adults, a higher proportion of young adults received IV tPA among patients without contraindicaitons (7.2% vs 6.1%, adjusted OR (aOR) 1.13, 95% CI 1.10 to 1.17) and among patients without contraindications and with onset-to-door time ≤3.5 hours (23.6% vs 19.3%, aOR 1.20, 95% CI 1.15 to 1.24). We did not observe differences in onset-to-needle time (median hours 2.7 hours) or door-to-needle time (DNT) (median minutes 60 min) between young and older adults. The proportion of DNT ≤30 min, DNT ≤45 min and DNT ≤60 min in young and older IV tPA-treated patients were 16.9% vs 18.8%, 30.2% vs 32.8% and 50.2% vs 54.2%, respectively. Compared with older adults, young adults treated with IV tPA had lower odds of in-hospital mortality (0.5% vs 1.3%, aOR 0.54, 95% CI 0.35 to 0.82) and higher odds of independent ambulation at discharge (61.0% vs 53.6%, aOR 1.15, 95% CI 1.08 to 1.22), and the associations may be partly explained by stroke severity measured by the National Institutes of Health Stroke Scale score.ConclusionYoung adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes. Background and purpose We aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator (IV tPA) and have shorter time to treatment than older patients with stroke.Methods We analysed data from the Chinese Stroke Center Alliance registry for patients with AIS hospitalised between August 2015 and July 2019. Patients were classified into two groups according to age: young adults (<50 years of age) and older adults (≥50 years of age).Results Of 793 175 patients with AIS admitted to 1471 hospitals, 9.1% (71 860) were young adults. Compared with older adults, a higher proportion of young adults received IV tPA among patients without contraindicaitons (7.2% vs 6.1%, adjusted OR (aOR) 1.13, 95% CI 1.10 to 1.17) and among patients without contraindications and with onset-to-door time ≤3.5 hours (23.6% vs 19.3%, aOR 1.20, 95% CI 1.15 to 1.24). We did not observe differences in onset-to-needle time (median hours 2.7 hours) or door-to-needle time (DNT) (median minutes 60 min) between young and older adults. The proportion of DNT ≤30 min, DNT ≤45 min and DNT ≤60 min in young and older IV tPA-treated patients were 16.9% vs 18.8%, 30.2% vs 32.8% and 50.2% vs 54.2%, respectively. Compared with older adults, young adults treated with IV tPA had lower odds of in-hospital mortality (0.5% vs 1.3%, aOR 0.54, 95% CI 0.35 to 0.82) and higher odds of independent ambulation at discharge (61.0% vs 53.6%, aOR 1.15, 95% CI 1.08 to 1.22), and the associations may be partly explained by stroke severity measured by the National Institutes of Health Stroke Scale score.Conclusion Young adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes. We aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator (IV tPA) and have shorter time to treatment than older patients with stroke.BACKGROUND AND PURPOSEWe aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator (IV tPA) and have shorter time to treatment than older patients with stroke.We analysed data from the Chinese Stroke Center Alliance registry for patients with AIS hospitalised between August 2015 and July 2019. Patients were classified into two groups according to age: young adults (<50 years of age) and older adults (≥50 years of age).METHODSWe analysed data from the Chinese Stroke Center Alliance registry for patients with AIS hospitalised between August 2015 and July 2019. Patients were classified into two groups according to age: young adults (<50 years of age) and older adults (≥50 years of age).Of 793 175 patients with AIS admitted to 1471 hospitals, 9.1% (71 860) were young adults. Compared with older adults, a higher proportion of young adults received IV tPA among patients without contraindicaitons (7.2% vs 6.1%, adjusted OR (aOR) 1.13, 95% CI 1.10 to 1.17) and among patients without contraindications and with onset-to-door time ≤3.5 hours (23.6% vs 19.3%, aOR 1.20, 95% CI 1.15 to 1.24). We did not observe differences in onset-to-needle time (median hours 2.7 hours) or door-to-needle time (DNT) (median minutes 60 min) between young and older adults. The proportion of DNT ≤30 min, DNT ≤45 min and DNT ≤60 min in young and older IV tPA-treated patients were 16.9% vs 18.8%, 30.2% vs 32.8% and 50.2% vs 54.2%, respectively. Compared with older adults, young adults treated with IV tPA had lower odds of in-hospital mortality (0.5% vs 1.3%, aOR 0.54, 95% CI 0.35 to 0.82) and higher odds of independent ambulation at discharge (61.0% vs 53.6%, aOR 1.15, 95% CI 1.08 to 1.22), and the associations may be partly explained by stroke severity measured by the National Institutes of Health Stroke Scale score.RESULTSOf 793 175 patients with AIS admitted to 1471 hospitals, 9.1% (71 860) were young adults. Compared with older adults, a higher proportion of young adults received IV tPA among patients without contraindicaitons (7.2% vs 6.1%, adjusted OR (aOR) 1.13, 95% CI 1.10 to 1.17) and among patients without contraindications and with onset-to-door time ≤3.5 hours (23.6% vs 19.3%, aOR 1.20, 95% CI 1.15 to 1.24). We did not observe differences in onset-to-needle time (median hours 2.7 hours) or door-to-needle time (DNT) (median minutes 60 min) between young and older adults. The proportion of DNT ≤30 min, DNT ≤45 min and DNT ≤60 min in young and older IV tPA-treated patients were 16.9% vs 18.8%, 30.2% vs 32.8% and 50.2% vs 54.2%, respectively. Compared with older adults, young adults treated with IV tPA had lower odds of in-hospital mortality (0.5% vs 1.3%, aOR 0.54, 95% CI 0.35 to 0.82) and higher odds of independent ambulation at discharge (61.0% vs 53.6%, aOR 1.15, 95% CI 1.08 to 1.22), and the associations may be partly explained by stroke severity measured by the National Institutes of Health Stroke Scale score.Young adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes.CONCLUSIONYoung adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes. |
| Author | Zhou, Qi Yang, Xin Wang, Yong-Jun Li, Zi-Xiao Gu, Hong-Qiu Wang, Yi-Long Wang, Hai-Yan Li, Hao Liu, Chelsea Jiang, Ying-Yu Jiang, Yong Meng, Xia Wang, Chun-Juan Liu, Li-Ping Zhao, Xing-Quan |
| AuthorAffiliation | 2 China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, Capital Medical University , Beijing , China 4 Vascular Neurology, Department of Neurology , Beijing Tiantan Hospital, Capital Medical University , Beijing , China 5 Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences , Beijing , China 3 National Center for Healthcare Quality Management in Neurological Diseases , Beijing Tiantan Hospital, Capital Medical University , Beijing , China 7 Department of Epidemiology , Harvard University T H Chan School of Public Health , Boston , Massachusetts , USA 1 Department of Neurology and Psychiatry , Beijing Shijitan Hospital, Capital Medical University , Beijing , China 6 Neuro-intensive Care Unit, Department of Neurology , Beijing Tiantan Hospital, Capital Medical University , Beijing , China |
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| Cites_doi | 10.2174/156720207781387213 10.1161/STROKEAHA.119.024156 10.1016/j.lpm.2016.10.003 10.1017/S031716710012027X 10.2169/internalmedicine.51.8027 10.1038/nrneurol.2014.72 10.1001/jama.283.22.2941 10.21037/atm.2018.08.13 10.1136/svn-2020-000457 10.1002/sim.3697 10.1161/STROKEAHA.111.000126 10.1136/svn-2018-000154 10.1159/000107390 10.1016/S1474-4422(16)30073-4 10.1007/s00415-008-0949-9 10.1007/s11910-019-1004-1 10.1186/1471-2377-11-109 10.2174/1567202614666170328095431 10.1016/j.jfma.2013.11.012 10.1212/WNL.0b013e3182a4a451 10.1161/STR.0000000000000211 10.1212/WNL.0000000000007651 10.1161/01.CIR.0000134791.68010.FA 10.1016/j.ahj.2005.03.061 10.1177/2396987321989865 10.1161/STROKEAHA.119.026848 10.1212/WNL.0000000000007653 10.1212/WNL.0b013e31824d966b 10.3329/jdmc.v26i2.38765 10.1212/wnl.0b013e3182a4a451 |
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| References | Berge, Whiteley, Audebert (R12) 2021; 6 Dodds, Xian, Sheng (R13) 2019; 92 George (R4) 2020; 51 Hsieh, Chen, Chen (R19) 2014; 113 Martínez-Sánchez, Díez-Tejedor, Fuentes (R10) 2007; 24 Suppl 1 Arnold, Halpern, Meier (R30) 2008; 255 Singhal, Biller, Elkind (R8) 2013; 81 Popa-Wagner, Carmichael, Kokaia (R31) 2007; 4 Shi, Cao, You (R17) 2017; 14 van Tuijn, Luitse, van der Valk (R20) 2010; 68 Schull, Vermeulen, Donovan (R27) 2005; 150 Cannon, Gibson, Lambrew (R26) 2000; 283 Poppe, Buchan, Hill (R16) 2009; 36 Habib, ASMR, Hossain (R22) 2018; 26 Zinkstok, Engelter, Gensicke (R25) 2013; 44 Toni, Ahmed, Anzini (R15) 2012; 78 Xiaobing, Li'an (R29) 2004; 012 Peña-Martínez, Durán-Laforet, García-Culebras (R9) 2019; 50 Gu, Li, Liu (R24) 2018; 6 Wang, Li, Gu (R7) 2020; 5 Papavasileiou, Goldstein (R14) 2019; 92 Rutten-Jacobs, Maaijwee, Arntz (R3) 2011; 11 Béjot, Bailly, Durier (R1) 2016; 45 Feigin, Roth, Naghavi (R6) 2016; 15 Chen, Zhan, Chen (R23) 2012; 51 Hathidara, Saini, Malik (R2) 2019; 19 Powers, Rabinstein, Ackerson (R11) 2019; 50 Maaijwee, Rutten-Jacobs, Schaapsmeerders (R5) 2014; 10 Austin (R21) 2009; 28 Wang, Li, Wang (R18) 2018; 3 Antman, Anbe, Armstrong (R28) 2004; 110 2022062407501404000_12.6.e055055.28 Chen (2022062407501404000_12.6.e055055.23) 2012; 51 2022062407501404000_12.6.e055055.26 Dodds (2022062407501404000_12.6.e055055.13) 2019; 92 2022062407501404000_12.6.e055055.25 Poppe (2022062407501404000_12.6.e055055.16) 2009; 36 Habib (2022062407501404000_12.6.e055055.22) 2018; 26 Shi (2022062407501404000_12.6.e055055.17) 2017; 14 van Tuijn (2022062407501404000_12.6.e055055.20) 2010; 68 Gu (2022062407501404000_12.6.e055055.24) 2018; 6 Papavasileiou (2022062407501404000_12.6.e055055.14) 2019; 92 2022062407501404000_12.6.e055055.21 2022062407501404000_12.6.e055055.18 Berge (2022062407501404000_12.6.e055055.12) 2021; 6 2022062407501404000_12.6.e055055.15 Schull (2022062407501404000_12.6.e055055.27) 2005; 150 Martínez-Sánchez (2022062407501404000_12.6.e055055.10) 2007; 24 Suppl 1 2022062407501404000_12.6.e055055.11 Hathidara (2022062407501404000_12.6.e055055.2) 2019; 19 2022062407501404000_12.6.e055055.9 Hsieh (2022062407501404000_12.6.e055055.19) 2014; 113 2022062407501404000_12.6.e055055.8 2022062407501404000_12.6.e055055.7 2022062407501404000_12.6.e055055.6 2022062407501404000_12.6.e055055.31 2022062407501404000_12.6.e055055.5 2022062407501404000_12.6.e055055.30 George (2022062407501404000_12.6.e055055.4) 2020; 51 Xiaobing (2022062407501404000_12.6.e055055.29) 2004; 012 2022062407501404000_12.6.e055055.3 2022062407501404000_12.6.e055055.1 |
| References_xml | – volume: 68 start-page: 123 year: 2010 ident: R20 article-title: Reduction of the door-to-needle time for administration of antibiotics in patients with a severe infection: a tailored intervention project publication-title: Neth J Med – volume: 4 start-page: 216 year: 2007 ident: R31 article-title: The response of the aged brain to stroke: too much, too soon? publication-title: Curr Neurovasc Res doi: 10.2174/156720207781387213 – volume: 51 start-page: 729 year: 2020 ident: R4 article-title: Risk factors for ischemic stroke in younger adults: a focused update publication-title: Stroke doi: 10.1161/STROKEAHA.119.024156 – volume: 45 start-page: e391 year: 2016 ident: R1 article-title: Epidemiology of stroke in Europe and trends for the 21st century publication-title: Presse Med doi: 10.1016/j.lpm.2016.10.003 – volume: 36 start-page: 161 year: 2009 ident: R16 article-title: Intravenous thrombolysis for acute ischaemic stroke in young adult patients publication-title: Can J Neurol Sci doi: 10.1017/S031716710012027X – volume: 51 start-page: 2887 year: 2012 ident: R23 article-title: The prognostic value of combined NT-pro-BNP levels and NIHSS scores in patients with acute ischemic stroke publication-title: Intern Med doi: 10.2169/internalmedicine.51.8027 – volume: 10 start-page: 315 year: 2014 ident: R5 article-title: Ischaemic stroke in young adults: risk factors and long-term consequences publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2014.72 – volume: 283 start-page: 2941 year: 2000 ident: R26 article-title: Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction publication-title: JAMA doi: 10.1001/jama.283.22.2941 – volume: 6 start-page: 326 year: 2018 ident: R24 article-title: %ggBaseline: a SAS macro for analyzing and reporting baseline characteristics automatically in medical research publication-title: Ann Transl Med doi: 10.21037/atm.2018.08.13 – volume: 5 start-page: 211 year: 2020 ident: R7 article-title: China stroke statistics 2019: a report from the National center for healthcare quality management in neurological diseases, China national clinical research center for neurological diseases, the Chinese stroke association, National center for chronic and non-communicable disease control and prevention, Chinese center for disease control and prevention and Institute for global neuroscience and stroke collaborations publication-title: Stroke Vasc Neurol doi: 10.1136/svn-2020-000457 – volume: 28 start-page: 3083 year: 2009 ident: R21 article-title: Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples publication-title: Stat Med doi: 10.1002/sim.3697 – volume: 44 start-page: 1080 year: 2013 ident: R25 article-title: Safety of thrombolysis in stroke mimics: results from a multicenter cohort study publication-title: Stroke doi: 10.1161/STROKEAHA.111.000126 – volume: 3 start-page: 256 year: 2018 ident: R18 article-title: Chinese stroke center alliance: a national effort to improve healthcare quality for acute stroke and transient ischaemic attack: rationale, design and preliminary findings publication-title: Stroke Vasc Neurol doi: 10.1136/svn-2018-000154 – volume: 24 Suppl 1 start-page: 143 year: 2007 ident: R10 article-title: Systemic reperfusion therapy in acute ischemic stroke publication-title: Cerebrovasc Dis doi: 10.1159/000107390 – volume: 15 start-page: 913 year: 2016 ident: R6 article-title: Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the global burden of disease study 2013 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(16)30073-4 – volume: 255 start-page: 1503 year: 2008 ident: R30 article-title: Age-Dependent differences in demographics, risk factors, co-morbidity, etiology, management, and clinical outcome of acute ischemic stroke publication-title: J Neurol doi: 10.1007/s00415-008-0949-9 – volume: 26 start-page: 90 year: 2018 ident: R22 article-title: Assessment of initial stroke severity by National Institute health stroke scale (NIHSS) score at admission publication-title: Journal of Dhaka Medical College – volume: 19 year: 2019 ident: R2 article-title: Stroke in the young: a global update publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-019-1004-1 – volume: 11 year: 2011 ident: R3 article-title: Risk factors and prognosis of young stroke. The future study: a prospective cohort study. study rationale and protocol publication-title: BMC Neurol doi: 10.1186/1471-2377-11-109 – volume: 14 start-page: 141 year: 2017 ident: R17 article-title: Young stroke patients treated with intravenous thrombolysis have a more favorable outcome and mortality compared with older patients publication-title: Curr Neurovasc Res doi: 10.2174/1567202614666170328095431 – volume: 113 start-page: 929 year: 2014 ident: R19 article-title: Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: video-assisted therapeutic risk communication publication-title: J Formos Med Assoc doi: 10.1016/j.jfma.2013.11.012 – volume: 81 start-page: 1089 year: 2013 ident: R8 article-title: Recognition and management of stroke in young adults and adolescents publication-title: Neurology doi: 10.1212/WNL.0b013e3182a4a451 – volume: 50 start-page: e344 year: 2019 ident: R11 article-title: Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American heart Association/American stroke association publication-title: Stroke doi: 10.1161/STR.0000000000000211 – volume: 92 start-page: 1129 year: 2019 ident: R14 article-title: Thrombolysis in young adults with acute ischemic stroke: quicker may be better publication-title: Neurology doi: 10.1212/WNL.0000000000007651 – volume: 110 start-page: 588 year: 2004 ident: R28 article-title: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction) publication-title: Circulation doi: 10.1161/01.CIR.0000134791.68010.FA – volume: 012 start-page: 354 year: 2004 ident: R29 article-title: Clinical investigation of stroke in young and middle-aged adults publication-title: Cerebrovascular Diseases Foreign Medical Sciences – volume: 150 start-page: 583 year: 2005 ident: R27 article-title: Can the wrong statistic be bad for health? Improving the reporting of door-to-needle time performance in acute myocardial infarction publication-title: Am Heart J doi: 10.1016/j.ahj.2005.03.061 – volume: 6 start-page: I year: 2021 ident: R12 article-title: European stroke organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke publication-title: Eur Stroke J doi: 10.1177/2396987321989865 – volume: 50 start-page: 3228 year: 2019 ident: R9 article-title: Pharmacological modulation of neutrophil extracellular traps reverses thrombotic stroke tPA (tissue-type plasminogen activator) resistance publication-title: Stroke doi: 10.1161/STROKEAHA.119.026848 – volume: 92 start-page: e2784 year: 2019 ident: R13 article-title: Thrombolysis in young adults with stroke: findings from get with the Guidelines-Stroke publication-title: Neurology doi: 10.1212/WNL.0000000000007653 – volume: 78 start-page: 880 year: 2012 ident: R15 article-title: Intravenous thrombolysis in young stroke patients: results from the SITS-ISTR publication-title: Neurology doi: 10.1212/WNL.0b013e31824d966b – volume: 14 start-page: 141 year: 2017 ident: 2022062407501404000_12.6.e055055.17 article-title: Young stroke patients treated with intravenous thrombolysis have a more favorable outcome and mortality compared with older patients publication-title: Curr Neurovasc Res doi: 10.2174/1567202614666170328095431 – ident: 2022062407501404000_12.6.e055055.25 doi: 10.1161/STROKEAHA.111.000126 – ident: 2022062407501404000_12.6.e055055.7 doi: 10.1136/svn-2020-000457 – volume: 6 start-page: 326 year: 2018 ident: 2022062407501404000_12.6.e055055.24 article-title: %ggBaseline: a SAS macro for analyzing and reporting baseline characteristics automatically in medical research publication-title: Ann Transl Med doi: 10.21037/atm.2018.08.13 – volume: 26 start-page: 90 year: 2018 ident: 2022062407501404000_12.6.e055055.22 article-title: Assessment of initial stroke severity by National Institute health stroke scale (NIHSS) score at admission publication-title: Journal of Dhaka Medical College doi: 10.3329/jdmc.v26i2.38765 – volume: 113 start-page: 929 year: 2014 ident: 2022062407501404000_12.6.e055055.19 article-title: Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: video-assisted therapeutic risk communication publication-title: J Formos Med Assoc doi: 10.1016/j.jfma.2013.11.012 – ident: 2022062407501404000_12.6.e055055.8 doi: 10.1212/wnl.0b013e3182a4a451 – volume: 012 start-page: 354 year: 2004 ident: 2022062407501404000_12.6.e055055.29 article-title: Clinical investigation of stroke in young and middle-aged adults publication-title: Cerebrovascular Diseases Foreign Medical Sciences – volume: 19 year: 2019 ident: 2022062407501404000_12.6.e055055.2 article-title: Stroke in the young: a global update publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-019-1004-1 – volume: 68 start-page: 123 year: 2010 ident: 2022062407501404000_12.6.e055055.20 article-title: Reduction of the door-to-needle time for administration of antibiotics in patients with a severe infection: a tailored intervention project publication-title: Neth J Med – ident: 2022062407501404000_12.6.e055055.1 doi: 10.1016/j.lpm.2016.10.003 – volume: 51 start-page: 2887 year: 2012 ident: 2022062407501404000_12.6.e055055.23 article-title: The prognostic value of combined NT-pro-BNP levels and NIHSS scores in patients with acute ischemic stroke publication-title: Intern Med doi: 10.2169/internalmedicine.51.8027 – volume: 24 Suppl 1 start-page: 143 year: 2007 ident: 2022062407501404000_12.6.e055055.10 article-title: Systemic reperfusion therapy in acute ischemic stroke publication-title: Cerebrovasc Dis doi: 10.1159/000107390 – ident: 2022062407501404000_12.6.e055055.15 doi: 10.1212/WNL.0b013e31824d966b – volume: 51 start-page: 729 year: 2020 ident: 2022062407501404000_12.6.e055055.4 article-title: Risk factors for ischemic stroke in younger adults: a focused update publication-title: Stroke doi: 10.1161/STROKEAHA.119.024156 – ident: 2022062407501404000_12.6.e055055.18 doi: 10.1136/svn-2018-000154 – volume: 92 start-page: 1129 year: 2019 ident: 2022062407501404000_12.6.e055055.14 article-title: Thrombolysis in young adults with acute ischemic stroke: quicker may be better publication-title: Neurology doi: 10.1212/WNL.0000000000007651 – ident: 2022062407501404000_12.6.e055055.21 doi: 10.1002/sim.3697 – ident: 2022062407501404000_12.6.e055055.9 doi: 10.1161/STROKEAHA.119.026848 – ident: 2022062407501404000_12.6.e055055.5 doi: 10.1038/nrneurol.2014.72 – ident: 2022062407501404000_12.6.e055055.28 doi: 10.1161/01.CIR.0000134791.68010.FA – ident: 2022062407501404000_12.6.e055055.30 doi: 10.1007/s00415-008-0949-9 – ident: 2022062407501404000_12.6.e055055.6 doi: 10.1016/S1474-4422(16)30073-4 – volume: 150 start-page: 583 year: 2005 ident: 2022062407501404000_12.6.e055055.27 article-title: Can the wrong statistic be bad for health? Improving the reporting of door-to-needle time performance in acute myocardial infarction publication-title: Am Heart J doi: 10.1016/j.ahj.2005.03.061 – volume: 92 start-page: e2784 year: 2019 ident: 2022062407501404000_12.6.e055055.13 article-title: Thrombolysis in young adults with stroke: findings from get with the Guidelines-Stroke publication-title: Neurology doi: 10.1212/WNL.0000000000007653 – ident: 2022062407501404000_12.6.e055055.26 doi: 10.1001/jama.283.22.2941 – ident: 2022062407501404000_12.6.e055055.31 doi: 10.2174/156720207781387213 – ident: 2022062407501404000_12.6.e055055.11 doi: 10.1161/STR.0000000000000211 – volume: 36 start-page: 161 year: 2009 ident: 2022062407501404000_12.6.e055055.16 article-title: Intravenous thrombolysis for acute ischaemic stroke in young adult patients publication-title: Can J Neurol Sci doi: 10.1017/S031716710012027X – ident: 2022062407501404000_12.6.e055055.3 doi: 10.1186/1471-2377-11-109 – volume: 6 start-page: I year: 2021 ident: 2022062407501404000_12.6.e055055.12 article-title: European stroke organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke publication-title: Eur Stroke J doi: 10.1177/2396987321989865 |
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| Snippet | Background and purposeWe aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue... We aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue plasminogen activator... Background and purpose We aimed to determine whether young adults (<50 years) with acute ischaemic stroke (AIS) are more likely to receive intravenous tissue... |
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| SubjectTerms | adult neurology Emergency medical care Intravenous therapy Ischemia Neurology Stroke Thrombolytic drugs vascular medicine Young adults |
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| Title | Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China |
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