Inflammatory and non-inflammatory roles for Toll-like receptors in gastrointestinal cancer

Collectively, cancers of the gastrointestinal (GI) tract (including the esophagus, stomach, duodenum, colon, rectum, liver, gall bladder and bile ducts) are the most prevalent and deadly worldwide. A common denominator in the pathogenesis of these GI tract cancers is chronic inflammation, as evidenc...

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Veröffentlicht in:Current pharmaceutical design Jg. 21; H. 21; S. 2968 - 2977
Hauptverfasser: West, Alison C, Jenkins, Brendan J
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United Arab Emirates 01.01.2015
Schlagworte:
Animals
Gastroenteritis - genetics
Gastroenteritis - pathology
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - pathology
Humans
Signal Transduction - genetics
Toll-Like Receptors - genetics
ISSN:1873-4286
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Abstract Collectively, cancers of the gastrointestinal (GI) tract (including the esophagus, stomach, duodenum, colon, rectum, liver, gall bladder and bile ducts) are the most prevalent and deadly worldwide. A common denominator in the pathogenesis of these GI tract cancers is chronic inflammation, as evidenced by the fact that sufferers of inflammatory bowel disease (IBD) are significantly more susceptible to colon cancer than healthy individuals. However, since only a relatively small proportion of individuals with chronic inflammatory conditions such as IBD go on to develop cancer, research has focused on identifying discrepancies in the host immune system that may be responsible for promoting carcinogenesis in inflamed tissue. To this end, molecular pathways linking inflammation and cancer are emerging, with one series of candidates being members of the Toll-like receptor family.
AbstractList Collectively, cancers of the gastrointestinal (GI) tract (including the esophagus, stomach, duodenum, colon, rectum, liver, gall bladder and bile ducts) are the most prevalent and deadly worldwide. A common denominator in the pathogenesis of these GI tract cancers is chronic inflammation, as evidenced by the fact that sufferers of inflammatory bowel disease (IBD) are significantly more susceptible to colon cancer than healthy individuals. However, since only a relatively small proportion of individuals with chronic inflammatory conditions such as IBD go on to develop cancer, research has focused on identifying discrepancies in the host immune system that may be responsible for promoting carcinogenesis in inflamed tissue. To this end, molecular pathways linking inflammation and cancer are emerging, with one series of candidates being members of the Toll-like receptor family.
Author West, Alison C
Jenkins, Brendan J
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  givenname: Brendan J
  surname: Jenkins
  fullname: Jenkins, Brendan J
  email: Brendan.Jenkins@monash.edu
  organization: Cancer and Immune Signaling Laboratory, Centre for Innate Immunity and Infectious Diseases, MIMRPHI Institute of Medical Research, 27-31 Wright St, Clayton, Victoria, 3168 Australia. Brendan.Jenkins@monash.edu
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SubjectTerms Animals
Gastroenteritis - genetics
Gastroenteritis - pathology
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - pathology
Humans
Signal Transduction - genetics
Toll-Like Receptors - genetics
Title Inflammatory and non-inflammatory roles for Toll-like receptors in gastrointestinal cancer
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