Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn’s disease
ObjectiveFollowing ileal resection for Crohn’s disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to a...
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| Vydané v: | Gut Ročník 69; číslo 3; s. 462 - 472 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
England
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.03.2020
BMJ Publishing Group LTD BMJ Publishing Group |
| Predmet: | |
| ISSN: | 0017-5749, 1468-3288, 1468-3288 |
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| Abstract | ObjectiveFollowing ileal resection for Crohn’s disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence.Patients and methodsIleal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France.ResultsIleal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors.ConclusionSurgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence. |
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| AbstractList | ObjectiveFollowing ileal resection for Crohn’s disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence.Patients and methodsIleal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France.ResultsIleal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors.ConclusionSurgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence. Following ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence. Ileal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France. Ileal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors. Surgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence. Objective Following ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence.Patients and methods Ileal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France.Results Ileal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors.Conclusion Surgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence. Following ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence.OBJECTIVEFollowing ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence.Ileal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France.PATIENTS AND METHODSIleal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France.Ileal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors.RESULTSIleal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors.Surgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence.CONCLUSIONSurgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence. |
| Author | Beaugerie, Laurent Goutte, Marion Baudry, Clotilde Nion-Larmurier, Isabelle Brazier, Franck Barnich, Nicolas Bourrier, Anne Falgon, Peggy Munoz-Bongrand, Nicolas Sabbagh, Charles Quevrain, Elodie Vazeille, Emilie Buisson, Anthony Marteau, Philippe Bezault, Madeleine Sommeville, Coralie Feron, Mariane Filippi, Jérome Tiret, Emmanuel Desreumaux, Pierre Nisard, Andrée Hoyau-Idrissi, Nadia Boyer, Sarah Charlois, Anne-Laure Lourenco, Nelson Cotte, Eddy Dupas, Jean-Louis Pariente, Benjamin Lefevre, Jeremie Stefanescu, Carmen Chatelain, Denis Moussata, Driffa Hebuterne, Xavier Gornet, Jean-Marc Rodrigues, Michael Nachury, Maria Panis, Yves Hafjisavvas, Hélène Margalef, Carole Magiorri, Leon Treton, Xavier Guedj, Nathalie Flourié, Bernard Allez, Matthieu François, Yves Seksik, Philippe Chafai, Najim Chirica, Mircea Corte, Hélène Hofmann, Paul Svreck, Magali Chauvenet, Marion Attencourt, Christophe Cattan, Pierre Boschetti, Gilles Brot, Loic Lechardeur, Jessica Tran-Minh, My-Linh Dray, Xavier Auzolle, Claire Coban, Dilek Fumery, Mathurin Le Bourhis, Lione |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31142586$$D View this record in MEDLINE/PubMed https://hal.science/hal-02193634$$DView record in HAL |
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| ContentType | Journal Article |
| Contributor | Beaugerie, Laurent Goutte, Marion Baudry, Clotilde Nion-Larmurier, Isabelle Brazier, Franck Bourrier, Anne Falgon, Peggy Munoz-Bongrand, Nicolas Sabbagh, Charles Quevrain, Elodie Vazeille, Emilie Marteau, Philippe Bezault, Madeleine Sommeville, Coralie Feron, Mariane Filippi, Jérome Tiret, Emmanuel Desreumaux, Pierre Nisard, Andrée Hoyau-Idrissi, Nadia Boyer, Sarah Charlois, Anne-Laure Lourenco, Nelson Cotte, Eddy Dupas, Jean-Louis Lefevre, Jeremie Chatelain, Denis Moussata, Driffa Hebuterne, Xavier Gornet, Jean-Marc Rodrigues, Michael Nachury, Maria Panis, Yves Hafjisavvas, Hélène Margalef, Carole Magiorri, Leon Guedj, Nathalie Flourié, Bernard François, Yves Chafai, Najim Chirica, Mircea Corte, Hélène Hofmann, Paul Svreck, Magali Chauvenet, Marion Attencourt, Christophe Cattan, Pierre Boschetti, Gilles Brot, Loic Lechardeur, Jessica Tran-Minh, My-Linh Dray, Xavier Coban, Dilek Maillet, Mariane Chaput, Ulrika Sauvanet, Pierre Flejou, Jean François Leconte, Martine Detre, Patricia Landman, Cecilia Bouhnik, Yoram Rajca, Sylvie Corcos, Olivier Bomme |
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| Copyright | Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. 2020 Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Distributed under a Creative Commons Attribution 4.0 International License |
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| DOI | 10.1136/gutjnl-2019-318719 |
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| Keywords | colonic microflora Crohn’s disease microbiota mucosa-associated Crohn's disease |
| Language | English |
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| Snippet | ObjectiveFollowing ileal resection for Crohn’s disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been... Following ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified,... Objective Following ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been... |
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| SubjectTerms | Adult Algorithms Bacteriology Biochemistry, Molecular Biology Biopsy colonic microflora Colonoscopy Crohn Disease - diagnostic imaging Crohn Disease - microbiology Crohn Disease - surgery Crohn's disease Deoxyribonucleic acid DNA Endoscopy Endoscopy, Gastrointestinal Female Firmicutes Gastrointestinal Microbiome Genetic testing Humans Ileum - microbiology Inflammatory bowel disease Intestinal microflora Intestinal Mucosa - microbiology Life Sciences Male Microbiology and Parasitology Microbiota Middle Aged Molecular biology Mucosa Patients Postoperative Period Prospective Studies Proteobacteria Recurrence Risk Factors Software Surgery Tumor necrosis factor-TNF Young Adult |
| Title | Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn’s disease |
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