Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn’s disease

ObjectiveFollowing ileal resection for Crohn’s disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to a...

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Podrobná bibliografia
Vydané v:	Gut Ročník 69; číslo 3; s. 462 - 472
Hlavní autori:	Sokol, Harry, Brot, Loic, Stefanescu, Carmen, Auzolle, Claire, Barnich, Nicolas, Buisson, Anthony, Fumery, Mathurin, Pariente, Benjamin, Le Bourhis, Lionel, Treton, Xavier, Nancey, Stéphane, Allez, Matthieu, Seksik, Philippe, Cattan, Pierre, Chirica, Mircea, Munoz-Bongrand, Nicolas, Corte, Hélène, Gornet, Jean-Marc, Baudry, Clotilde, Lourenco, Nelson, Maillet, Mariane, Tran-Minh, My-Linh, Nisard, Andrée, Beaugerie, Laurent, Bourrier, Anne, Nion-Larmurier, Isabelle, Landman, Cecilia, Rajca, Sylvie, Quevrain, Elodie, Chafai, Najim, Lefevre, Jeremie, Tiret, Emmanuel, Svreck, Magali, Hoyau-Idrissi, Nadia, Flejou, Jean François, Guedj, Nathalie, Panis, Yves, Magiorri, Leon, Feron, Mariane, Bouhnik, Yoram, Corcos, Olivier, Dray, Xavier, Chaput, Ulrika, Marteau, Philippe, Bommelaer, Gilles, Goutte, Marion, Vazeille, Emilie, Rodrigues, Michael, Sauvanet, Pierre, Coban, Dilek, Desreumaux, Pierre, Nachury, Maria, Sommeville, Coralie, Dupas, Jean-Louis, Brazier, Franck, Chatelain, Denis, Attencourt, Christophe, Sabbagh, Charles, Leconte, Martine, Boschetti, Gilles, Flourié, Bernard, François, Yves, Cotte, Eddy, Charlois, Anne-Laure, Falgon, Peggy, Moussata, Driffa, Chauvenet, Marion, Boyer, Sarah, Hafjisavvas, Hélène, Hebuterne, Xavier, Filippi, Jérome, Hofmann, Paul, Lechardeur, Jessica, Bezault, Madeleine, Margalef, Carole, Detre, Patricia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.03.2020 BMJ Publishing Group LTD BMJ Publishing Group
Predmet:	Adult Algorithms Bacteriology Biochemistry, Molecular Biology Biopsy colonic microflora Colonoscopy Crohn Disease - diagnostic imaging Crohn Disease - microbiology Crohn Disease - surgery Crohn's disease Deoxyribonucleic acid DNA Endoscopy Endoscopy, Gastrointestinal Female Firmicutes Gastrointestinal Microbiome Genetic testing Humans Ileum - microbiology Inflammatory bowel disease Intestinal microflora Intestinal Mucosa - microbiology Life Sciences Male Microbiology and Parasitology Microbiota Middle Aged Molecular biology Mucosa Patients Postoperative Period Prospective Studies Proteobacteria Recurrence Risk Factors Software Surgery Tumor necrosis factor-TNF Young Adult France United States > US California colonic microflora Crohn’s disease microbiota mucosa-associated Crohn's disease
ISSN:	0017-5749, 1468-3288, 1468-3288
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Popis
Shrnutí:	ObjectiveFollowing ileal resection for Crohn’s disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence.Patients and methodsIleal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France.ResultsIleal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors.ConclusionSurgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence.
Bibliografia:	Original research ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0017-5749 1468-3288 1468-3288
DOI:	10.1136/gutjnl-2019-318719