Role of Vegetarianism, Smoking, and Hydroxocobalamin in Optic Neuritis

Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the...

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Vydáno v:British Medical Journal Ročník 3; číslo 5821; s. 264 - 267
Hlavní autoři: Wadia, N. H., Desai, M. M., Quadros, E. V., Dastur, D. K.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England British Medical Journal Publishing Group 29.07.1972
British Medical Association
BMJ Publishing Group LTD
Témata:
Adolescent
Adrenocorticotropic Hormone - therapeutic use
Adult
Amblyopia
Cigarette smoking
Cyanides
Diet, Vegetarian
Female
Folic Acid - blood
Follow-Up Studies
Functional Laterality
Humans
Male
Middle Aged
Optic neuritis
Optic Neuritis - blood
Optic Neuritis - drug therapy
Optic Neuritis - etiology
Papers and Originals
Pipe smoking
Prednisolone - therapeutic use
Scotoma - etiology
Smoking
Thiocyanates
Thiocyanates - blood
Tobacco smoking
Vegetarianism
Visual Acuity
Vitamin B 12 - blood
Vitamin B 12 - therapeutic use
Vitamin B12
ISSN:0007-1447, 1468-5833
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Shrnutí:Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B12 and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case. No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B12 or of an increase in the proportion of non-cyanide-extracted B12 in the serum.
Bibliografie:local:bmj;3/5821/264
href:bmj-3-264.pdf
PMID:4339973
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ISSN:0007-1447
1468-5833
DOI:10.1136/bmj.3.5821.264