Role of Vegetarianism, Smoking, and Hydroxocobalamin in Optic Neuritis

Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the...

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Vydané v:	British Medical Journal Ročník 3; číslo 5821; s. 264 - 267
Hlavní autori:	Wadia, N. H., Desai, M. M., Quadros, E. V., Dastur, D. K.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England British Medical Journal Publishing Group 29.07.1972 British Medical Association BMJ Publishing Group LTD
Predmet:	Adolescent Adrenocorticotropic Hormone - therapeutic use Adult Amblyopia Cigarette smoking Cyanides Diet, Vegetarian Female Folic Acid - blood Follow-Up Studies Functional Laterality Humans Male Middle Aged Optic neuritis Optic Neuritis - blood Optic Neuritis - drug therapy Optic Neuritis - etiology Papers and Originals Pipe smoking Prednisolone - therapeutic use Scotoma - etiology Smoking Thiocyanates Thiocyanates - blood Tobacco smoking Vegetarianism Visual Acuity Vitamin B 12 - blood Vitamin B 12 - therapeutic use Vitamin B12
ISSN:	0007-1447, 1468-5833
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Abstract	Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B12 and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case. No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B12 or of an increase in the proportion of non-cyanide-extracted B12 in the serum.
AbstractList	Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B12 and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case. No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B12 or of an increase in the proportion of non-cyanide-extracted B12 in the serum. Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B₁₂ and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case. No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B₁₂ or of an increase in the proportion of non-cyanide-extracted B₁₂ in the serum. Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B(12) and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case.No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B(12) or of an increase in the proportion of non-cyanide-extracted B(12) in the serum.Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B(12) and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case.No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B(12) or of an increase in the proportion of non-cyanide-extracted B(12) in the serum. Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B 12 and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case. No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B12 or of an increase in the proportion of non-cyanide-extracted B12 in the serum. Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B(12) and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case.No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B(12) or of an increase in the proportion of non-cyanide-extracted B(12) in the serum.
Author	Wadia, N. H. Desai, M. M. Dastur, D. K. Quadros, E. V.
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SubjectTerms	Adolescent Adrenocorticotropic Hormone - therapeutic use Adult Amblyopia Cigarette smoking Cyanides Diet, Vegetarian Female Folic Acid - blood Follow-Up Studies Functional Laterality Humans Male Middle Aged Optic neuritis Optic Neuritis - blood Optic Neuritis - drug therapy Optic Neuritis - etiology Papers and Originals Pipe smoking Prednisolone - therapeutic use Scotoma - etiology Smoking Thiocyanates Thiocyanates - blood Tobacco smoking Vegetarianism Visual Acuity Vitamin B 12 - blood Vitamin B 12 - therapeutic use Vitamin B12
Title	Role of Vegetarianism, Smoking, and Hydroxocobalamin in Optic Neuritis
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