Morphometry of blood monocytes in malignant lymphoma

Morphometric methods were used to study the ultrastructure of blood monocytes in 23 patients with Hodgkin's disease, 12 patients with non-Hodgkin's lymphoma, and 20 normal subjects. The results were analysed using both univariate and multivariate methods. Both analyses supported the interp...

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Bibliographic Details
Published in:Journal of clinical pathology Vol. 38; no. 8; pp. 904 - 907
Main Authors: Sokol, R J, Hudson, G, Wales, J, James, N T
Format: Journal Article
Language:English
Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.08.1985
BMJ
BMJ Publishing Group LTD
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cell Nucleus - pathology
Chromatin - analysis
Euchromatin
Female
Hematologic and hematopoietic diseases
Heterochromatin - analysis
Hodgkin Disease - blood
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma - blood
Male
Medical sciences
Middle Aged
Mitochondria - pathology
Monocytes - ultrastructure
Human
Monocyte
Cytologic investigation
Hodgkin disease
Hemopathy
Non Hodgkin lymphoma
Morphometry
Blood
ISSN:0021-9746, 1472-4146
Online Access:Get full text
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Summary:Morphometric methods were used to study the ultrastructure of blood monocytes in 23 patients with Hodgkin's disease, 12 patients with non-Hodgkin's lymphoma, and 20 normal subjects. The results were analysed using both univariate and multivariate methods. Both analyses supported the interpretation that the total mitochondrial contribution to the cellular ultrastructure was less in Hodgkin's disease than in the other two groups, with smaller mitochondrial volume fractions, volumes, and surface areas being found. In the patients with non-Hodgkin's lymphoma univariate analysis suggested that monocyte nuclei were larger, with more euchromatin and a relatively smaller heterochromatin-euchromatin interface; the cell profile area was larger and the surface to volume ratio was smaller compared with normal subjects. Morphological changes have not previously been described in blood monocytes in malignant lymphoma, but they may be the counterpart of the known mononuclear phagocyte dysfunction.
Bibliography:istex:BF0D778E60A6D7D8FCEC9128E2C96C078D1CE148
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PMID:4031102
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ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.38.8.904