Multiple embolic stroke due to aortic arch floating thrombus in latent tertiary syphilis
At admittance serological tests (RPR 1:25, TPPA 1:10240, IgM anti-Treponema Pallidum negative, total antibodies against Treponema pallidum >70.00), the absence of history and the absence of previous treatment with penicillin led to the diagnosis of latent syphilis.
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| Vydané v: | BMJ case reports Ročník 2013; s. bcr2013200910 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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England
BMJ Publishing Group Ltd
22.11.2013
BMJ Publishing Group LTD BMJ Publishing Group |
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| ISSN: | 1757-790X, 1757-790X |
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| Abstract | At admittance serological tests (RPR 1:25, TPPA 1:10240, IgM anti-Treponema Pallidum negative, total antibodies against Treponema pallidum >70.00), the absence of history and the absence of previous treatment with penicillin led to the diagnosis of latent syphilis. |
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| AbstractList | At admittance serological tests (RPR 1:25, TPPA 1:10240, IgM anti-Treponema Pallidum negative, total antibodies against Treponema pallidum >70.00), the absence of history and the absence of previous treatment with penicillin led to the diagnosis of latent syphilis. The first brain CT scan was negative, but 24 h later evidenced multiple ischaemic infarctions in the brain (right cerebellar hemisphere, Broca's area; figure 1). Despite the lack of histological confirmation (the patient did not undergo cardiothoracic surgery because of the favourable outcome) we concluded that the explanation was luetic aortic damage,4 which could have promoted the thrombus growth with consequent multiple symptomatic embolisms. n The patient was anticoagulated with continuous heparin infusion for several days followed by oral sodic warfarin (international normalised ratio (INR) 2.5–3) and treated with intravenous penicillin at the dose of 1 g every 6 h for 10 days. Contributors PR contributed in the conception and design, acquisition of data, analysis and interpretation of data; drafting the article; final approval of the version published. |
| Author | Farinelli, Pamela Mittino, Daniela Ripellino, Paolo Cantello, Roberto |
| AuthorAffiliation | 2 Department of Dermatology , University of Eastern Piedmont, AOU Maggiore della Carità , Novara , Italy 1 Department of Neurology , University of Eastern Piedmont, AOU Maggiore della Carità , Novara , Italy |
| AuthorAffiliation_xml | – name: 1 Department of Neurology , University of Eastern Piedmont, AOU Maggiore della Carità , Novara , Italy – name: 2 Department of Dermatology , University of Eastern Piedmont, AOU Maggiore della Carità , Novara , Italy |
| Author_xml | – sequence: 1 givenname: Paolo surname: Ripellino fullname: Ripellino, Paolo organization: Department of Neurology, University of Eastern Piedmont, AOU Maggiore della Carità, Novara, Italy – sequence: 2 givenname: Daniela surname: Mittino fullname: Mittino, Daniela organization: Department of Neurology, University of Eastern Piedmont, AOU Maggiore della Carità, Novara, Italy – sequence: 3 givenname: Pamela surname: Farinelli fullname: Farinelli, Pamela organization: Department of Dermatology, University of Eastern Piedmont, AOU Maggiore della Carità, Novara, Italy – sequence: 4 givenname: Roberto surname: Cantello fullname: Cantello, Roberto organization: Department of Neurology, University of Eastern Piedmont, AOU Maggiore della Carità, Novara, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24272985$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_avsg_2025_06_005 crossref_primary_10_1016_j_jemermed_2019_01_017 crossref_primary_10_3390_ijerph192416992 crossref_primary_10_1186_s12879_017_2624_1 crossref_primary_10_7759_cureus_9397 crossref_primary_10_1016_j_anndiagpath_2015_01_003 |
| Cites_doi | 10.1161/01.CIR.29.3.346 10.1080/00313020600820898 10.1053/j.sult.2011.12.001 10.1016/j.amjcard.2009.07.031 |
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| References | Heggtveit (R4) 1964; 2013 Roberts, Ko, Vowels (R3) 2009; 2013 Tavora, Burke (R1) 2006; 2013 Katabathina, Restrepo (R2) 2012; 2013 Roberts, Ko, Vowels 2009; 2013 Tavora, Burke 2006; 2013 Katabathina, Restrepo 2012; 2013 Heggtveit 1964; 2013 Tavora (2025082701533473000_2013.nov22_1.bcr2013200910.1) 2006; 2013 Roberts (2025082701533473000_2013.nov22_1.bcr2013200910.3) 2009; 2013 Heggtveit (2025082701533473000_2013.nov22_1.bcr2013200910.4) 1964; 2013 Katabathina (2025082701533473000_2013.nov22_1.bcr2013200910.2) 2012; 2013 22624966 - Semin Ultrasound CT MR. 2012 Jun;33(3):207-21 16916717 - Pathology. 2006 Aug;38(4):302-8 14128825 - Circulation. 1964 Mar;29:346-55 19932796 - Am J Cardiol. 2009 Dec 1;104(11):1578-87 |
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| Snippet | At admittance serological tests (RPR 1:25, TPPA 1:10240, IgM anti-Treponema Pallidum negative, total antibodies against Treponema pallidum >70.00), the absence... The first brain CT scan was negative, but 24 h later evidenced multiple ischaemic infarctions in the brain (right cerebellar hemisphere, Broca's area; figure... |
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| SubjectTerms | 51-70 years Aged Antibodies Anticoagulants Anticoagulants - administration & dosage Aorta, Thoracic - diagnostic imaging Aorta, Thoracic - pathology Aortic Arch Syndromes - diagnostic imaging Aortic Arch Syndromes - etiology Blood clots Cerebellum - diagnostic imaging Embolisms Europe (West) Heparin - administration & dosage Humans Images In Immunoglobulins Male Medical imaging Penicillin Radiography Serology Stroke - diagnosis Stroke - etiology Syphilis Syphilis, Latent - complications Thrombosis - diagnostic imaging Thrombosis - drug therapy Thrombosis - etiology White |
| Title | Multiple embolic stroke due to aortic arch floating thrombus in latent tertiary syphilis |
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