Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients

Background/aimsTo validate the predictive value of the American Joint Committee on Cancer (AJCC) 8th-edition classification for local recurrence, metastasis and survival in patients with eyelid sebaceous carcinoma.MethodsWe performed a retrospective review of 100 consecutive patients with eyelid seb...

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Vydáno v:British journal of ophthalmology Ročník 103; číslo 7; s. 980 - 984
Hlavní autoři: Sa, Ho-Seok, Rubin, Maria Laura, Xu, Shiqiong, Ning, Jing, Tetzlaff, Michael, Sagiv, Oded, Kandl, Thomas J, Esmaeli, Bita
Médium: Journal Article
Jazyk:angličtina
Vydáno: England BMJ Publishing Group LTD 01.07.2019
Témata:
Adult
Aged
Aged, 80 and over
Biopsy
Cancer therapies
Chemotherapy
Classification
Committees
Ethnicity
Eye cancer
Eyelid Neoplasms - diagnosis
Eyelid Neoplasms - mortality
Eyelid Neoplasms - secondary
Eyelids - pathology
Family medical history
Female
Follow-Up Studies
Head & neck cancer
Humans
Incidence
Lymphatic Metastasis
Lymphatic system
Male
Medical prognosis
Metastasis
Middle Aged
Neoplasm Recurrence, Local - epidemiology
Neoplasm Staging
Ophthalmology
Patients
Plastic surgery
Prognosis
Retrospective Studies
Sebaceous Gland Neoplasms - diagnosis
Sebaceous Gland Neoplasms - mortality
Sebaceous Gland Neoplasms - secondary
Survival Rate - trends
Tumors
United States - epidemiology
United States
United States > US
eyelid carcinoma
metastasis
8th TNM
AJCC
survival
staging system
sebaceous carcinoma
ISSN:0007-1161, 1468-2079, 1468-2079
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Shrnutí:Background/aimsTo validate the predictive value of the American Joint Committee on Cancer (AJCC) 8th-edition classification for local recurrence, metastasis and survival in patients with eyelid sebaceous carcinoma.MethodsWe performed a retrospective review of 100 consecutive patients with eyelid sebaceous carcinoma. Eyelid carcinomas were staged according to the AJCC 7th-edition and 8th-edition criteria. Associations between T and N categories and disease-related outcomes including local recurrence, lymph node metastasis, distant metastasis and survival were evaluated.Results60 women and 40 men had a median age of 67 years (range, 41–94 years). The proportions of patients who experienced local recurrence, lymph node metastasis, distant metastasis and death from disease were 6%, 21%, 7% and 6%, respectively. Two-year and 5-year disease-specific survival (DSS) rates were 93.8% and 92.0%, respectively. There were significant correlations between (1) T2c or worse category and lymph node metastasis (p=0.04) and distant metastasis (p=0.01), (2) T3b or worse category and local recurrence (p=0.01) and death from disease (p=0.01) and (3) N1 category at presentation and distant metastasis (p<0.01) and death from disease (p<0.01). The AJCC 8th-edition classification showed a better homogeneity of the T-category distribution (p<0.01) and a slightly higher discrimination ability for lymph node metastasis (C=0.734 vs C=0.728) than the 7th-edition.ConclusionsT and N categories per AJCC 8th-edition classification are predictive of local recurrence, metastasis and DSS outcomes for eyelid sebaceous carcinoma. Surgeons should perform strict surveillance testing for nodal and systemic metastases in patients with T2c or worse T category and/or N1 disease at presentation.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-1161
1468-2079
1468-2079
DOI:10.1136/bjophthalmol-2018-312635