Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial

Objective To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza.Design Double blind randomised trial.Setting Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam.Participants Patients age...

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Vydané v:	BMJ (Online) Ročník 346; číslo 7911; s. 12
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England British Medical Journal Publishing Group 30.05.2013 BMJ Publishing Group BMJ Publishing Group Ltd
Predmet:	Administration, Oral Adult Antiviral Agents - administration & dosage Child Children Clinical Protocols - standards Clinical trials Dosage Dose-Response Relationship, Drug Double-Blind Method Health outcomes Hemagglutination Inhibition Tests - statistics & numerical data Hospital admissions Hospitalization - statistics & numerical data Humans Indonesia Infant Influenza A virus - classification Influenza A virus - drug effects Influenza A virus - physiology Influenza B virus - drug effects Influenza B virus - physiology Influenza, Human - drug therapy Influenza, Human - mortality Influenza, Human - physiopathology Influenza, Human - virology Intensive care units Middle Aged Oseltamivir - administration & dosage Oxygen Practice Guidelines as Topic Reverse Transcriptase Polymerase Chain Reaction - methods Reverse Transcriptase Polymerase Chain Reaction - statistics & numerical data Severity of Illness Index Singapore Thailand Treatment Outcome Ventilation systems Vietnam Virology Viruses Vietnam Singapore Thailand Indonesia
ISSN:	0959-8138, 1756-1833, 1756-1833
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