Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB115 alleles

ObjectivesDrug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, delayed hypersensitivity reaction (DHR). We observed DRESS to inhibitors of interleukin 1 (IL-1) or IL-6 in a small group of patients with Still’s disease with atypical lung disease. We sought to characterise featur...

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Bibliographic Details
Published in:	Annals of the rheumatic diseases Vol. 81; no. 3; pp. 406 - 415
Main Authors:	Saper, Vivian E, Ombrello, Michael J, Tremoulet, Adriana H, Montero-Martin, Gonzalo, Prahalad, Sampath, Canna, Scott, Shimizu, Chisato, Deutsch, Gail, Tan, Serena Y, Remmers, Elaine F, Monos, Dimitri, Hahn, Timothy, Phadke, Omkar K, Cassidy, Elaine, Ferguson, Ian, Mallajosyula, Vamsee, Xu, Jianpeng, Rosa Duque, Jaime S, Chua, Gilbert T, Ghosh, Debopam, Szymanski, Ann Marie, Rubin, Danielle, Burns, Jane C, Tian, Lu, Fernandez-Vina, Marcelo A, Mellins, Elizabeth D, Hollenbach, Jill A, Aziz, Rabheh Abdul, Berard, Roberta, Bingham, Catherine A, Bonaparth, Alexis D, Casey, Alicia, Collins, Kathleen P, Cidon, Michal, Goodman, Steven I, Grom, Alexei A, Hazen, Melissa, Hoftman, Alice, Ibarra, Maria, Jerath, Rita, Kingsbury, Daniel J, Klein-Gitelman, Marisa S, Lai, Khanh, Lapidus, Sivia, Mendoza-Londono, Roberto, Onel, Karen, Perez, Maria, Radhakrishna, Suhas M, Reinhardt, Adam, Riskalla, Mona, Roth, Johannes, Rosenwasser, Natalie, Saad, Nadine, Schulert, Grant S, Shenoi, Susan, Smith, Judith A, Soep, Jennifer, Stingl, Cory, Stoll, Matthew L, Tesher, Melissa, Whitehead, Benjamin, Zemel, Lawrence, Anton, Jordi, Bohnsack, John F, Cobb, Joanna, Demirkaya, Erkan, Foell, Dirk, Gattorno, Marco, Grom, Alexei, Hilario, Maria Odete, Ilowite, Norman T, Haas, Johannes-Peter, Hinks, Anne, Kastner, Daniel L, Langfeld, Carl D, Martini, Alberto, Minden, Kirsten, Oliveira, Sheila, Özen, Seza, Rosen-Wolff, Angela, Rosenberg, Alan, Russo, Ricardo, Signa, Sara, Tachmazidou, Ioanna, Tenbrock, Klaus, Thompson, Susan, Thomson, Wendy, Wedderburn, Lucy R, Woo, Patricia, Yeung, Rae S M, Zeft, Andrew S, Len, Claudio
Format:	Journal Article
Language:	English
Published:	United States BMJ Publishing Group Ltd and European League Against Rheumatism 01.03.2022 Elsevier Limited
Subjects:	Adult adult-onset Alleles Antigens Antirheumatic Agents - adverse effects Arthritis biological therapy Case-Control Studies Cell activation Children Classification Cytokines Drb1 protein Drug Hypersensitivity Syndrome - genetics Drug Hypersensitivity Syndrome - immunology Drug Tolerance - genetics Eosinophilia Female Gene frequency Haplotypes Histocompatibility antigen HLA HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology Humans Hypersensitivity (delayed) Hypersensitivity, Delayed - genetics Hypersensitivity, Delayed - immunology Interleukin 1 Interleukin 1 receptor antagonist Interleukin 6 Interleukin-1 - antagonists & inhibitors Interleukin-6 - antagonists & inhibitors juvenile Kawasaki disease Laboratories Lung diseases Lymphocytes Macrophages Male Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - drug therapy Mucocutaneous Lymph Node Syndrome - genetics Patients Peptides pharmacogenetics Retrospective Studies Steroids Still's disease Still's Disease, Adult-Onset - drug therapy Still's Disease, Adult-Onset - genetics Still's Disease, Adult-Onset - immunology Tissue typing Treatment Vigilance Still's disease adult-onset juvenile arthritis biological therapy pharmacogenetics
ISSN:	0003-4967, 1468-2060, 1468-2060
Online Access:	Get full text
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