Cross-sectional evaluation of host biomarkers for guiding antibiotic use in bacterial and non-bacterial acute febrile illness in low- and middle-income tropical settings

ObjectivesTo evaluate the effectiveness of 18 different host biomarkers in differentiating bacterial from non-bacterial acute febrile illness (AFI) in resource-limited settings, specifically in Brazil, Malawi and Gabon.DesignMultinational, cross-sectional study.SettingThe study was carried out acros...

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Bibliographic Details
Published in:	BMJ open Vol. 15; no. 2; p. e086912
Main Authors:	Fernandez-Carballo, B Leticia, Atzeni, Michele, Escadafal, Camille, Vettoretti, Martina, Geis, Steffen, Agnandji, Selidji Todagbe, Siqueira, Andre M, Malava, Jullita Kenala, Banda, Louis, Kabwende, Anita L, Alabi, Ayodele, Ondo, Juste Christin Bie, Massinga-Loembe, Marguerite, Essone, Paulin N, Moreira, José, da Rocha Matos, Aline, Caetano, Braulia C, Siqueira, Marilda M, Bispo de Filippis, Ana Maria, dos Santos Ribeiro da Silva, Érica Aparecida, Lourenço, Maria Cristina S, Häring, Julia, Günther, Anna, Jakobi, Meike, Schneiderhan-Marra, Nicole, Hoogland, Christine, Brasil, Patrícia, Pokharel, Sunil, Ongarello, Stefano, Harris, Victoria, Macé, Aurélien, Lee, Sue J, Di Camillo, Barbara, Dittrich, Sabine
Format:	Journal Article
Language:	English
Published:	England British Medical Journal Publishing Group 13.02.2025 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Acute Disease Adult Aged Anti-Bacterial Agents Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial infections Bacterial Infections - blood Bacterial Infections - diagnosis Bacterial Infections - drug therapy Biomarkers Biomarkers - blood Brazil Child Classification Cross-Sectional Studies Diagnostic tests Diagnostics Female Fever Fever - diagnosis Fever - drug therapy Fever - microbiology Gabon Health facilities Humans Infections Laboratories Low income groups Malaria Malawi Male Middle Aged Original Research Patients Product development Proteins Public health ROC Curve Viral infections Young Adult Brazil Gabon Malawi Malaria Anti-Bacterial Agents Public health
ISSN:	2044-6055, 2044-6055
Online Access:	Get full text
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