Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage

Following proliferation of oogonia inmammals, great numbers of germ cells are discarded, primarily by apoptosis, while the remainder form primordial follicles (the ovarian reserve) that determine fertility and reproductive lifespan. More massive, rapid, and essentially total loss of oocytes, however...

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Bibliographic Details
Published in:	Biology of reproduction Vol. 98; no. 4; pp. 532 - 542
Main Authors:	D'Ignazio, Laura, Michel, Marc, Beyer, Melissa, Thompson, Kassimier, Forabosco, Antonino, Schlessinger, David, Pelosi, Emanuele
Format:	Journal Article
Language:	English
Published:	United States Society for the Study of Reproduction 01.04.2018 Oxford University Press
Subjects:	Ablation Apoptosis Autophagy Deoxyribonucleic acid DNA DNA damage Gene expression Lhx8 oocyte ovarian reserve OVARY reproduction Reproductive health autophagy oocyte DNA damage Lhx8 apoptosis ovarian reserve reproduction
ISSN:	0006-3363, 1529-7268, 1529-7268
Online Access:	Get full text
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