Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments

Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeate...

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Bibliographic Details
Published in:Current pharmaceutical design Vol. 28; no. 4; p. 272
Main Authors: Du, Yi, Li, Kaijun, Liu, Wei, Song, Ruitong, Luo, Meifeng, He, Jianfeng, Xu, Xiaoyu, Qu, Xiaosheng
Format: Journal Article
Language:English
Published: United Arab Emirates 01.01.2022
Subjects:
Aquaporin 4
Autoantibodies
Humans
Neuromyelitis Optica - diagnosis
Neuromyelitis Optica - drug therapy
Spinal Cord
pathogenesis
AQP4
Devic’s disease
autoimmunity
therapy
NMOSD
ISSN:1873-4286, 1873-4286
Online Access:Get more information
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Summary:Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of the current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and disability rates are high. In the present work, we review recent advances in the diagnosis and treatment of patients with NMOSD, as well as the pathogenesis and mechanisms of AQP4-IgG-seropositive NMOSD.
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ISSN:1873-4286
1873-4286
DOI:10.2174/1381612827666210329101335