Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis

RationaleWe hypothesised that patients with acute respiratory distress syndrome (ARDS) can be clustered based on concentrations of plasma biomarkers and that the thereby identified biological phenotypes are associated with mortality.MethodsConsecutive patients with ARDS were included in this prospec...

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Bibliographic Details
Published in:	Thorax Vol. 72; no. 10; pp. 876 - 883
Main Authors:	Bos, L D, Schouten, L R, van Vught, L A, Wiewel, M A, Ong, D S Y, Cremer, O, Artigas, A, Martin-Loeches, I, Hoogendijk, A J, van der Poll, T, Horn, J, Juffermans, N, Calfee, C S, Schultz, M J
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 01.10.2017
Subjects:	Aged Angiopoietin-1 - blood Angiopoietin-2 - blood Biomarkers - blood Cluster Analysis Female Humans Intensive care Intensive Care Units Interferon-gamma - blood Interleukin-6 - blood Male Middle Aged Mortality Phenotype Plasminogen Activator Inhibitor 1 - blood Predictive Value of Tests Prospective Studies Respiratory Distress Syndrome, Adult - blood Respiratory Distress Syndrome, Adult - mortality Respiratory therapy Cytokine Biology ARDS
ISSN:	0040-6376, 1468-3296, 1468-3296
Online Access:	Get full text
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